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Preclinical activities of Cassia tora Linn against aging-related diseases

Published online by Cambridge University Press:  25 October 2022

Sun-Young Hwang ,
Chang-Su Na ,
Byeong Cheol Moon ,
Jung-Hyun Shim  and
Mee-Hyun Lee Open the ORCID record for Mee-Hyun Lee [Opens in a new window]
Sun-Young Hwang
Affiliation:
College of Korean Medicine, Dongshin University, Naju 58245, Republic of Korea
Chang-Su Na
Affiliation:
College of Korean Medicine, Dongshin University, Naju 58245, Republic of Korea
Byeong Cheol Moon
Affiliation:
Herbal Medicine Resources Research Center, Korea Institute of Oriental Medicine, Naju 58245, Republic of Korea
Jung-Hyun Shim*
Affiliation:
Department of Pharmacy, College of Pharmacy, Mokpo National University, Jeonnam 58554, Republic of Korea Department of Biomedicine, Health & Life Convergence Sciences, BK21 FOUR, Mokpo National University, Jeonnam 58554, Republic of Korea The China-US (Henan) Hormel Cancer Institute, Zhengzhou, Henan 450008, P.R. China
Mee-Hyun Lee*
Affiliation:
College of Korean Medicine, Dongshin University, Naju 58245, Republic of Korea
*
Authors for correspondence: Jung-Hyun Shim, E-mail: s1004jh@gmail.com, Mee-Hyun Lee, E-mail: mhlee@dsu.ac.kr (mhyun_lee@hanmail.net)
Authors for correspondence: Jung-Hyun Shim, E-mail: s1004jh@gmail.com, Mee-Hyun Lee, E-mail: mhlee@dsu.ac.kr (mhyun_lee@hanmail.net)
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Abstract

Globally, an aging population is increasing, and aging is a natural physiological process and a major risk factor for all age-related diseases. It seriously threatens personal health and imposes a great economic burden. Therefore, there is a growing scientific interest in strategies for well-aging with prevention and treatment of age-related diseases. The seed, root, stem or leaves of Cassia tora Linn. are useful for anti-bacteria, anti-hyperlipidemia and anti-obesity due to its pharmacological activities such as anti-inflammation and anti-oxidant both in vitro and in vivo. Nevertheless, no clinical trials have been attempted so far, therefore here we would like to understand the current preclinical activities for aging-related disease models including cataract, metabolic dysfunction and neurodegeneration, then discuss their preparation for clinical trials and perspectives.

Keywords

Animal modelantioxidantCassia tora Linndiseasepreclinical
Type
Review
Information
Expert Reviews in Molecular Medicine , Volume 24 , 2022 , e43
Copyright
Copyright © The Author(s), 2022. Published by Cambridge University Press

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Footnotes

*

Authors have equally contributed.

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