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Roles of CCR10/CCL27–CCL28 axis in tumour development: mechanisms, diagnostic and therapeutic approaches, and perspectives

Published online by Cambridge University Press:  26 September 2022

Ermias Mergia Terefe ,
Maria Jade Catalan Opulencia ,
Amir Rakhshani ,
Mohammad Javed Ansari ,
Sergushina Elena Sergeevna ,
Sura A. Awadh ,
Djamila Sh. Polatova ,
Adnan Hashim Abdulkadhim ,
Yasser Fakri Mustafa  and
Hamzah H. Kzar
...Show all authors
Ermias Mergia Terefe
Affiliation:
School of Pharmacy and Health Science, United States International University, Nairobi, Kenya
Maria Jade Catalan Opulencia
Affiliation:
College of Business Administration, Ajman University, Ajman, United Arab Emirates
Amir Rakhshani
Affiliation:
Department of Pharmaceutical Nanotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
Mohammad Javed Ansari
Affiliation:
Department of Pharmaceutics, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia
Sergushina Elena Sergeevna
Affiliation:
National Research Ogarev Mordovia State University, 68, Bolshevitskaya str., 430005 Saransk, Republic of Mordovia, Russia
Sura A. Awadh
Affiliation:
Department of Anesthesia Techniques, Al-Mustaqbal University College, Hillah, Iraq
Djamila Sh. Polatova
Affiliation:
Department of Oncology and Medical Radiology, Tashkent State Dental Institute, Tashkent, Uzbekistan
Adnan Hashim Abdulkadhim
Affiliation:
Department of Computer Engineering, Technical Engineering College, Al-Ayen University, Thi-Qar, Iraq
Yasser Fakri Mustafa
Affiliation:
Department of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul 41001, Iraq
Hamzah H. Kzar
Affiliation:
Veterinary Medicine College, Al-Qasim Green University, Al-Qasim, Iraq
Moaed E. Al-Gazally
Affiliation:
College of Medicine, University of Al-Ameed, Karbala, Iraq
Mustafa M. Kadhim
Affiliation:
Department of Dentistry, Kut University College, Kut, Wasit 52001, Iraq College of Technical Engineering, The Islamic University, Najaf, Iraq Department of Pharmacy, Osol Aldeen University College, Baghdad, Iraq
Gholamali Taherian*
Affiliation:
Halal Research Center of IRI, FDA, Tehran, Iran
*
Author for correspondence: Gholamali Taherian, E-mail: rzalitaheri@gmail.com
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Abstract

Cancer is now one of the major causes of death across the globe. The imbalance of cytokine and chemokine secretion has been reported to be involved in cancer development. Meanwhile, CC chemokines have received considerable interest in cancer research. CCR10, as the latest identified CC chemokine receptor (CCR), has been implicated in the recruitment and infiltration of immune cells, especially lymphocytes, into epithelia such as skin via ligation to two ligands, CCL27 and CCL28. Other than homoeostatic function, several mechanisms have been shown to dysregulate CCR10/CCL27–CCL28 expression in the tumour microenvironment. As such, these receptors and ligands mediate T-cell trafficking in the tumour microenvironment. Depending on the types of lymphocytes recruited, CCR10/CCL27–CCL28 interaction has been shown to play conflicting roles in cancer development. If they were T helper and cytotoxic T cells and natural killer cells, the role of this axis would be tumour-suppressive. In contrast, if CCR10/CCL27–CCL28 recruited regulatory T cells, cancer-associated fibroblasts or myeloid-derived suppressor cells, it would lead to tumour progression. In addition to the trafficking of lymphocytes and immune cells, CCR10 also leads to the migration of tumour cells or endothelial cells (called angiogenesis and lymphangiogenesis) to promote tumour metastasis. Furthermore, CCR10 signalling triggers tumour-promoting signalling such as PI3K/AKT and mitogen-activated protein kinase/extracellular signal-regulated kinase, resulting in tumour cell growth. Since CCR10/CCL27–CCL28 is dysregulated in the tumour tissues, it is suggested that analysis and measurement of them might predict tumour development. Finally, it is hoped using therapeutic approaches based on this axis might increase our knowledge to overcome tumour progression.

Keywords

CancerCCL27CCL28CCR10chemokine
Type
Review
Information
Expert Reviews in Molecular Medicine , Volume 24 , 2022 , e37
Copyright
Copyright © The Author(s), 2022. Published by Cambridge University Press

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