Hostname: page-component-cd9895bd7-jkksz Total loading time: 0 Render date: 2024-12-27T11:10:01.492Z Has data issue: false hasContentIssue false

Main properties of steviol glycosides and theirpotential in the food industry: a review

Published online by Cambridge University Press:  07 March 2014

Cesar González*
Affiliation:
Programa Ing. Agroind., Decanato Agron., Univ. Centroccident. “Lisandro Alvarado”, Av. Florencio Jiménez, Barquisimeto 3001, Venezuela. cesargonzalez@ucla.edu.ve
María Tapia
Affiliation:
Inst. Cienc. Tecnol. Aliment., Fac. Cienc., Univ. Cent. Venezuela, Calle Suapure, Lomas de Bello Monte, Caracas 1050, Venezuela
Elevina Pérez
Affiliation:
Inst. Cienc. Tecnol. Aliment., Fac. Cienc., Univ. Cent. Venezuela, Calle Suapure, Lomas de Bello Monte, Caracas 1050, Venezuela
Dominique Pallet
Affiliation:
CIRAD, UMR 95 QualiSud, TA B-95/16, F-34398 Montpellier cedex 5 France
Manuel Dornier
Affiliation:
Montpellier SupAgro, UMR 95 QualiSud, BP 5098, F-34093 Montpellier cedex 5, France
*
* Correspondence and reprints
Get access

Abstract

Introduction. In recent decades, there has been increased interest in developing natural non-caloric sweeteners, providing sensory properties similar to sucrose. One of the most promising alternatives is the steviol glycosides, high-sweetness compounds extracted from the leaves of Stevia rebaudiana Bertoni. Characteristics and properties. In this review article, the characteristics of this plant are described. According to the relevant literature data, this review provides insight into the major steviol glycosides as well as their main characteristics and properties. Toxicity and legislation. We describe the current situation on the toxicity and the legal framework of the above sweeteners. Extraction techniques. This review describes the techniques developed for extraction and purification, including conventional extraction with water/solvent, ion exchange, enzymatic extraction, supercritical fluid and with a focus on membrane filtration, for its proven advantages in the purification of aqueous extract obtained by leaching of the leaves. Applications. This review also presents various evidence relating to the implementation of steviol glycosides in the food industry, with an emphasis on their use in the formulation of fruit juices. Conclusions. Finally, the future prospects of these natural sweeteners are presented. They highlight the need for research in this area, and the great appeal and commercial potential of such compounds, which should be focused on continuous assessment in relation to issues such as the intensity, persistence of sweetness and the absence of other residual flavors, in order to ensure their acceptance, preference and choice by the general public.

Type
Original article
Copyright
© 2014 Cirad/EDP Sciences

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Priya, K., Gupta, V.R., Srikanth, K., Natural sweeteners: A complete review, J. Pharm. Res. 4 (2011) 20342039.Google Scholar
Porto, J.M., Bolini, H.M., Descriptive profile of peach nectar sweetened with sucrose and different sweeteners, J. Sens. Stud. 23 (2008) 804816.CrossRefGoogle Scholar
Puri, M., Sharma, D., Tiwari, A.K., Downstream processing of stevioside and its potential applications, Biotechnol. Adv. 29 (2011) 781791.CrossRefGoogle Scholar
Sharoba, A.M., El-Desouky, A.I., Mahmoud, M.H., Effect of addition some hydrocolloids and sweeteners on flow behavior and sensory properties of papaya-apricot nectar blends, J. Food Process. Technol. 3 (2012) 38.Google Scholar
Chhaya, R., Mondal, S., Majumdar, G.C., Sirshendu, D.E., Clarifications of stevia extract using cross flow ultrafiltration and concentration by nanofiltration, Sep. Purif. Technol. 89 (2012) 125134.CrossRefGoogle Scholar
Dacome, A.S., Da Silva, C.C., Da Costa, C.E., Sweet diterpenic glycosides balance of a new cultivar of Stevia rebaudiana Bertoni: Isolation and quantitative distribution by chromatographic, spectroscopic, and electrophoretic methods, Process. Biochem. 40 (2005) 35873594.CrossRefGoogle Scholar
Ohta, M., Sasa, S., Inoue, A., Tamai, I., Fujita, I., Morita, K., Matsuura, F., Characterization of novel steviol glycosides from leaves of Stevia rebaudiana Morita, J. Appl. Glycosci. 57 (2010) 199209.CrossRefGoogle Scholar
Wölwer, U., The leaves of Stevia rebaudiana (Bertoni), their constituents and the analyses thereof: a review, J. Agric. Food Chem. 60 (2012) 886895.CrossRefGoogle Scholar
Geuns, J.M., Buyse, J., Vankeirsbilk, A., Temme, E., Metabolism of stevioside by healthy subjects, Exp. Biol. Med. 232 (2006) 164173.Google ScholarPubMed
Huxtable R.J., Pharmacology and toxicology of stevioside, rebaudioside A, and steviol. Stevia: the genus Stevia, Taylor and Francis, London, U.K. / New York, U.S.A., 2002, 160–177.
Prakash, I., Dubois, G.E., Clos, J.F., Wilkens, K.L., Fosdick, L.E., Development of rebiana, a natural, non-caloric sweetener, Food Chem. Toxicol. 46 (2008) Suppl. 7 S7582.CrossRefGoogle ScholarPubMed
Chaturvedula, V.S., Prakash, I., A new diterpene glycoside from Stevia rebaudiana, Molecules 16 (2011) 29372943.CrossRefGoogle Scholar
Vanneste, J., Sotto, A., Courtin, C., Application of tailor-made membranes in a multi-stage process for the purification of sweeteners from Stevia rebaudiana, J. Food Eng. 103 (2011) 285293.CrossRefGoogle Scholar
Reis, M.H., Da Silva, F.V., Andrade, C.M., Clarification and purification of aqueous Stevia extract using membrane separation process, J. Food Eng. 32 (2009) 338354. CrossRefGoogle Scholar
Erkucuk, A., Akgun, I.H., Yesil-Celiktas, O., Supercritical CO2 extraction of glycosides from Stevia rebaudiana leaves: Identification and optimization, J. Supercrit. Fluid. 51 (2009) 2935.CrossRefGoogle Scholar
Ateh, J.O., Onagbesan, O.M., Tona, K., Decuypere, E., Geuns, J.M., Buyse, J., Evaluation of supplementary stevia (Stevia rebaudiana, Bertoni) leaves and stevioside in boiler diets: effect on feed intake, nutrient metabolism blood parameters and growth performance, J. Anim. Physiol. Anim. Nutr. 92 (2008) 640649.CrossRefGoogle Scholar
Maki, K.C., Curry, L.L., Reeves, M.S., Toth, P.D., Mckenney, J.M., Farmer, M.V., Schwartz, S.L., Lubin, B.C., Boileau, A.C., Dicklin, M.R., Carakostas, M.C., Tarka, S.M., Chronic consumption of rebaudioside A, a steviol glycoside, in men and women with type 2 diabetes mellitus, Food Chem. Toxicol. 46 (2008) 4753.CrossRefGoogle ScholarPubMed
Wingard, E.R., Brown, J.P., Enderlin, F.E., Dale, J.A., Hale, R.L., Seitz, C.T., Intestinal degradation and absorption of the glycosidic sweeteners stevioside and rebaudioside A, Cell. Mol. life Sci. 36 (1980) 519520.CrossRefGoogle ScholarPubMed
Toyoda, K., Matsui, H., Shoda, T., Uneyama, C., Takada, K., Takahashi, M., Assesment of the carcinogenicity of stevioside in F344 rats, Food Chem. Toxicol. 35 (1997) 597603.CrossRefGoogle Scholar
Kochikyan, V.T., Markosyan, A.A., Abelyan, L.A., Balayan, A.M., Abelyan, V.A., Combined enzymatic modification of stevioside and rebaudioside A, Appl. Biochem. Microbiol. 42 (2006) 3137.CrossRefGoogle Scholar
Gregersen, S., Jeppesen, P.B., Holst, J.J., Hermansen, K., Antihyperglycemic effects of stevioside in type 2 diabetic subjects, Metabolism 53 (2004) 7376.CrossRefGoogle ScholarPubMed
Feri, L.A., Alves, W., Yamada, S.S., Gazola, S., Batista, M.R., Bazotte, R.B., Investigation of antihypertensive effect of oral crude stevioside in patients with mild essential hypertension, Phytother. Res. 20 (2006) 732736.CrossRefGoogle Scholar
Hsieh, M.H., Chan, P., Sue, Y.M., Liu, J.C., Liang, T.H., Huang, T.Y., Tomlinson, B., Chow, M.S., Kao, P.F., Chen, Y.J., Efficacy and tolerability of oral stevioside in plants with mild essential hypertension: A two year, randomized, placebo controlled study, Clin. Ther. 25 (2003) 27972808.CrossRefGoogle Scholar
Chatsudthipong, V., Muanprasat, C., Stevioside and related compounds: Therapeutic benefits beyond sweetness, Pharm. Ther. 121 (2009) 4154.CrossRefGoogle ScholarPubMed
Puri, M., Sharma, D., Barrow, C., Optimisation of novel method for the extraction of steviosides from Stevia rebaudiana leaves, Food Chem. 132 (2012) 11131120.CrossRefGoogle Scholar
Brusick, D., A critical review of the genetic toxicity of steviol and steviol glycosides, Food Chem. Toxicol. 46 (2008) S85S90.CrossRefGoogle Scholar
Chatsudthipong, V., Muanprasat, C., Stevioside and related compounds; therapeutic benefits beyond sweetness, Pharmacol. Ther. 121 (2009) 4154.CrossRefGoogle ScholarPubMed
Carakostas, M., Curry, L., Boileau, A., Brusick, D., Overview: The history, technical function and safety of rebaudioside A, a naturally occurring steviol glycoside, for use in food and beverages, Food Chem. Toxicol. 46 (2008) S5S9.CrossRefGoogle ScholarPubMed
Kroyer, G., The low calorie sweetener stevioside: Stability and interaction with food ingredients, Lebensm. Wiss. Technol. 32 (1999) 509512.CrossRefGoogle Scholar
Abou-Arab, A.E., Abou-Arab, A.A., Abu-Salem, M.F., Physico-chemical assessment of natural sweeteners steviosides produced from Stevia rebaudiana Bertoni plant, Afr. J. Food Sci. 4 (2010) 269281.Google Scholar
Jooken, E., Amery, R., Struyf, T., Duquenne, B., Geuns, J., Meesschaert, B., Stability of steviol glycosides in several food matrices, J. Agric. Food Chem. 42 (2012) 1060610612.CrossRefGoogle Scholar
Woelwer, U., Tomberg, W., Wawrzun, A., Investigations on the stability of stevioside and rebaudioside A in soft drinks, J. Agric. Food Chem. 58 (2010) 1221612220. CrossRefGoogle Scholar
Gardana, C., Simonetti, P., Canzi, E., Zanchi, R., Pietta, P.G., Metabolism of stevioside and rebaudioside A from Stevia rebaudiana extracts by human microflora, J. Agric. Food Chem. 51 (2003) 66186622.CrossRefGoogle ScholarPubMed
Prakash, I., Clos, J., Chaturvedula, V., Stability of rebaudioside A under acidic conditions and its degradation products, Food Res. Int. 48 (2012) 6575.CrossRefGoogle Scholar
Moraes, E., Machado, N., Clarification of Stevia rebaudiana (Bert.) extract by adsorption in modified zeolites, Acta Scientiarum 23 (2001) 13751380.Google Scholar
Jaitak, V., Bandna, B. S., Kaul, V. K., An efficient microwave-assisted extraction process of stevioside and rebaudioside-A from Stevia rebaudiana (Bertoni), Phytochem. Anal. 20 (2009) 240245.CrossRefGoogle Scholar
Yoda, S., Marques, M., Petenate, A., Meireles, M., Supercritical fluid extraction from Stevia rebaudiana Bertoni using CO2 and CO2 + water: extraction kinetics and identification of extracted components, J. Food Eng. 57 (2003) 125134.CrossRefGoogle Scholar
Tan S., Shibuta Y., Tanaka O., Isolation of sweetener from Stevia rebaudiana, Jpn. Kokai, Patent No. 63 177 764, 1983.
Xie, J., Wang, P., Su, W., Application of chitosan flocculation method in clarification of water extract from Stevia rebaudiana Bertoni leaves and flocculation mechanism analysis, Food Sci. 32 (2012) 16.Google Scholar
Abelyan V.H., Ghochikyan V.T., Markosyan A., Adamyan M.O., Abelyan L.A., Extraction, separation and modification of sweet glycosides from the Stevia rebaudiana plant, Patent No. US 7 838 044 B2, 2010.
Markosyan A., Purkayastha S., Malsagov M., Process for manufacturing a sweetener and use thereof, Patent No. US 2011/0 195 169 A1, 2011.
Abelyan V.H., Markosyan A., Abelyan L.A., High-purity rebaudioside D, Patent No. US 2011/0 092 684 A1, 2011.
Zhang, S., Kumar, S., Kutowy, O., Membrane-based separation scheme for processing weeteners from Stevia leaves, Food Res. Int. 33 (2000) 617620.CrossRefGoogle Scholar
Mondal, S., Chhaya, R., De, S., Prediction of ultrafiltration performance during clarification of stevia extract, J. Membr. Sci. 396 (2012) 138148.CrossRefGoogle Scholar
Mondal, S., Chhaya, R., De, S., Modeling of cross flow ultrafiltration of Stevia extract in a rectangular cell, J. Food Eng. 112 (2012) 326337.CrossRefGoogle Scholar
Chhaya, R., Mondal, S., Majumdar, G.C., De, S., Clarifications of Stevia extract using cross flow ultrafiltration and concentration by nanofiltration, Separation Purif. Technol. 89 (2012) 125134.CrossRefGoogle Scholar
Mondal S., Rai C., De S., Identification of fouling mechanism during ultrafiltration of Stevia extract, Food Bioprocess Technol. (2011) 1–10.
Kinghorn, A.D., Soejarto, D.D., Kennelly, E.J., Kim, D.S., Ohtani, K., Yamasaki, K., The genus Stevia, Med. Arom. Plants-Ind. Profiles 19 (2002) 5264.Google Scholar
Lisak, K., Jeličić, I., Tratnik, L., Božanić, R., Sensory evaluation of the strawberry flavored yoghurt with stevia and sucrose addition, Croat. J. Food Technol. Biotechnol. Nutr. 7 (2012) 3943.Google Scholar
Guggisberg, D., Piccinali, P., Schreier, K., Effects of sugar substitution with Stevia, Actilight and Stevia combinations or Palatinose on rheological and sensory characteristics of low-fat and whole milk set yogurt, Int. Dairy J. 21 (2011) 636644.CrossRefGoogle Scholar
Manisha, G., Soumya, C., Indrani, D., Studies on interaction between stevioside, liquid sorbitol, hydrocolloids and emulsifiers for replacement of sugar in cakes, Food Hydrocoll. 29 (2012) 363373.CrossRefGoogle Scholar
Belscak, A., Bonkovic, M., Komes, D., Bauman, I., Horzic, D., Dujmic, F., Matijasec, M., Physical properties and bioactive constituents of powdered mixtures and drinks prepared with cocoa and various sweeteners, J. Agric. Food Chem. 58 (2010) 71877195.CrossRefGoogle Scholar
Mogran, R., Dashora, V., Exploring the use of Stevia rebaudiana as a sweetener in comparison with other sweeteners, J. Hum. Ecol. 25 (2009) 117120.Google Scholar
Marcellini, P.S., Deliza, R., Bolini, H.M., Caracterização sensorial de suco de abacaxi concentrado, reconstituído e adoçado com diferentes edulcorantes e sacarose, Alim. Nutr. 17 (2006) 143150.Google Scholar
Fernandes, A.G., Machado, P.H., Maia, G., Silva, D.S., Santos, S.M., Sensory evaluation of guava drinks sweetened with different sweetening agents, Ciênc. Tecnol. Aliment. 29 (2009) 358364.CrossRefGoogle Scholar
Koguishi, C.A., Alves, V.H., Bolini, H.M., Equi-sweetness and sweetening power of guava nectars sweetned with different sweetening agents, Rev. Bras. Tecnol. Agroind. 2 (2008) 2636.Google Scholar
Cavallini, C.U., Bolini, H.M., Comparação da percepção temporal de doçura, amargor e sabor de fruta em suco de manga reconstituído e adoçado com sacarose, mistura ciclamato/sacarina 2:1, aspartame, sucralose e estévia, Bol. CEPPA 23 (2005) 361382.Google Scholar