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Biochemical and genetic characterization of esterase-27 (ES-27), the major plasma cholinesterase of the house mouse (Mus musculus)*

Published online by Cambridge University Press:  14 April 2009

O. H. von Deimling  and
A. Gaa
O. H. von Deimling*
Affiliation:
Pathologisches Institut, Abteilung für Chemische Pathologie, Universtität Freiburg, D-7800 Freiburg i. Br., Bundesrepublik, Deutschland
A. Gaa
Affiliation:
Pathologisches Institut, Abteilung für Chemische Pathologie, Universtität Freiburg, D-7800 Freiburg i. Br., Bundesrepublik, Deutschland
*
† Corresponding author.
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Esterase-27A (ES-27A) was characterized in strain A/WySnA by a cascade of seven bands seen after disc electrophoresis of serum and subsequent staining for esterase. ES-27A catalyses the hydrolysis of thiocholine butyrate and is strongly inhibited by 100 μm tetraisopropyl pyrophosphamide (isoOMPA). Hence, the enzyme was concluded to be a cholinesterase EC 3.1.1.8. A heat-labile form termed ES-27B was represented by strain AKR/Han. From a three-point cross (AKR/Han, A/Wy) and a five-point cross (AKR/Han, SEG/1), the gene order on chromosome 3 was concluded to be centromere–Car-2–Es-26–Es-27–Amy-1–Adh-1.

Type
Research Article
Information
Genetics Research , Volume 57 , Issue 1 , February 1991 , pp. 61 - 70
Copyright
Copyright © Cambridge University Press 1991

Footnotes

*

This work was supported by the Deutsche Forschungs-gemeinschaft (De 315/2). This is Communication no. 68 of a research programme devoted to the cellular distribution, regulation and genetics of non-specific esterases.

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