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Mapping and characterization of a ‘speciation gene’ in Drosophila

Published online by Cambridge University Press:  14 April 2009

H. Allen Orr
H. Allen Orr
Affiliation:
Center for Population Biology, University of California, Davis, CA 95616
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Almost nothing is known about the identity of the genes causing reproductive isolation between species. As a first step towards molecular isolation of a ‘speciation gene’, I mapped and partly characterized a gene causing hybrid male sterility in Drosophila. This analysis shows that sterility of D. melanogaster males who carry the ‘dot’ fourth chromosome from D. simulans is due entirely to a very small region of the D. simulans chromosome (including only about 5 salivary gland bands or approximately 250 kb of DNA). Thus the hybrid sterility effect of the D. simulans fourth chromosome is almost surely due to a single gene of very large effect (here named hms, hybrid male sterile). Hms is zygotically acting, and the D. simulans allele of hms is completely recessive. Furthermore, complementation tests suggest that hms is not an allele of any known locus in D. melanogaster.

Type
Research Article
Information
Genetics Research , Volume 59 , Issue 2 , April 1992 , pp. 73 - 80
Copyright
Copyright © Cambridge University Press 1992

References

Bridges, C. (1935). Cytological data on chromosome four of Drosophila melanogaster. Trudy Dinamika Razvit 10, 463–474.Google Scholar
Coyne, J. A. (1984). Genetic basis of male sterility in hybrids between two closely related species of Drosophila. Proceedings of the National Academy of Sciences, U.S.A. 81, 4444–4447.Google Scholar
Coyne, J. A. & Charlesworth, B. (1986). Location of an X-linked factor causing sterility in male hybrids of D. simulans and D. mauritiana. Heredity 57, 243–246.CrossRefGoogle ScholarPubMed
Coyne, J. A. & Charlesworth, B. (1989). Genetic analysis of X-linked sterility in hybrids between three sibling species of Drosophila. Heredity 62, 97–106.CrossRefGoogle ScholarPubMed
Coyne, J. A. & Orr, H. A. (1989). Two rules of speciation. In Speciation and its Consequences (ed. Otte, D. and Endler, J.), pp. 180–207. Sunderland, MA: Sinauer Associates.Google Scholar
Dobzhansky, T. (1937). Genetics and the Origin of Species. New York: Columbia University Press.Google Scholar
Engels, W. R. & Preston, C. R. (1979). Hybrid dysgenesis in Drosophila melanogaster: the biology of male and female sterility. Genetics 92, 161–174.Google Scholar
Frank, S. A. (1991). Divergence of meiotic drive-suppression systems as an explanation for sex-biased hybrid sterility and inviability. Evolution 45, 262–267.Google Scholar
Fuller, M. T. (1986). Genetic analysis of spermatogenesis in Drosophila: the role of testis-specific β tubulin and interacting genes in cellular morphogenesis. In Gametogenesis and the Early Embryo (ed. Gall, J. G.), pp. 19–41. New York: A. R. Liss.Google Scholar
Guenet, J.-L., Nagamine, C., Simon-Chazottes, D., Montagutelli, X. & Bonhomme, F. (1990). Hst-3: an X-linked hybrid sterility gene. Genetical Research 56, 163–165.Google Scholar
Hochman, B. (1973). Analysis of a whole chromosome in Drosophila. Cold Spring Harbor Symposium on Quantitative Biology 38, 581–589.CrossRefGoogle Scholar
Hochman, B. (1976). The fourth chromosome of Drosophila melanogaster. In The Genetics and Biology of Drosophila, Vol. 1 b (ed. Ashburner, M. and Novitski, E.), pp. 903–928. London: Academic Press.Google Scholar
Horton, I. R. (1939). A comparison of the salivary gland chromosomes of Drosophila melanogaster and D. simulans. Genetics 24, 234–243.Google Scholar
Hurst, L. D. & Pomiankowski, A. (1991). Causes of sex ratio bias may account for unisexual sterility in hybrids: a new explanation of Haldane's rule and related phenomena. Genetics 128, 841–858.Google Scholar
Kidwell, M. G. (1983). Evolution of hybrid dysgenesis determinants in Drosophila melanogaster. Proceedings of the National Academy of Sciences U.S.A. 80, 1655–1659.Google Scholar
Lindsley, D. L. & Grell, E. H. (1968). Genetic Variations of Drosophila melanogaster. Carnegie Institution, Washington, publication no. 627.Google Scholar
Lindsley, D. L. & Lifschytz, E. (1972). The genetic control of spermatogenesis in Drosophila. In The Genetics of the Spermatozoon (ed. Beatty, R. A. and Gluecksohn, S.-Waelsch), pp. 203–222. Copenhagen: Bogtrykkeriet Fo-rum Mayr E., (1988). Toward a New Philosophy of Biology. Cambridge, MA: Harvard University Press.Google Scholar
Muller, H. J. (1940). Bearing of the Drosophila work on systematics. In The New Systematics (ed. Huxley, J. S.), pp. 185–268. Oxford: Clarendon Press.Google Scholar
Muller, H. J. (1942). Isolating mechanisms, evolution, and temperature. Biological Symposia 6, 71–125.Google Scholar
Muller, H. J. & Pontecorvo, G. (1940). Recombinants between Drosophila species the Fl hybrids of which are sterile. Nature 145, 199–200.Google Scholar
Muller, H. J. & Pontecorvo, G. (1942). Recessive genes causing interspecific sterility and other disharmonies between Drosophila melanogaster and simulans. Genetics 27, 157.Google Scholar
Orr, H. A. (1989a). Genetics of sterility in hybrids between two subspecies of Drosophila. Evolution 43, 180–189.Google Scholar
Orr, H. A. (1989 b). Localization of genes causing postzygotic isolation in two hybridizations involving Drosophila pseudoobscura. Heredity 63, 231–237.Google Scholar
Pantazidis, A. C. & Zouros, E. (1988). Location of an autosomal factor causing sterility in Drosophila mojavensis males carrying the Drosophila arizonensis Y chromosome. Heredity 60, 299–304.Google Scholar
Pontecorvo, G. (1943). Hybrid sterility in artificially produced recombinants between Drosophila melanogaster and D. simulans. Proceedings of the Royal Society, Edinburgh B 61, 385–397.Google Scholar
Rose, M. R. & Doolittle, W. F. (1983). Molecular biological mechanisms of speciation. Science 220, 157–162.CrossRefGoogle ScholarPubMed
Slizynski, B. M. (1941). The structural differentiation of the chromosome IV of Drosophila simulans and its behaviour in melanogaster genotype. Proceedings of the Royal Society, Edinburgh B 61, 95–106.Google Scholar
Slizynski, B. M. (1944). A revised map of salivary gland chromosome 4. Journal of Heredity 32, 322–325.Google Scholar
Sorsa, V. (1988). Chromosome maps of Drosophila (2 volumes). Boca Raton, FL: CRC Press.Google Scholar
Uphoff, D. E. (1949). The expression of alleles at the cubitus interruptus locus in hybrids between Drosophila melanogaster and Drosophila simulans. Genetics 34, 315–327.CrossRefGoogle Scholar
Wittbrodt, J., Adam, D., Malitschek, B., Maueler, W., Raulf, F., Telling, A., Robertson, S. M. & Schartl, M. (1989). Novel putative receptor tyrosine kinase encoded by the melanoma-inducing Tu locus in Xiphophorus. Nature 341, 415–421.Google Scholar
Zouros, E., Lofdahl, K. & Martin, P. A. (1988). Male hybrid sterility in Drosophila: interactions between autosomes and sex chromosomes in crosses of D. mohavensis and,D. arizonensis. Evolution 42, 1321–1331Google Scholar