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A model of mutation appropriate to estimate the number of electrophoretically detectable alleles in a finite population*

Published online by Cambridge University Press:  14 April 2009

Tomoko Ohta  and
Motoo Kimura
Tomoko Ohta
Affiliation:
National Institute of Genetics, Mishima, Japan
Motoo Kimura
Affiliation:
National Institute of Genetics, Mishima, Japan
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Summary

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A new model of mutational production of alleles was proposed which may be appropriate to estimate the number of electrophoretically detectable alleles maintained in a finite population. The model assumes that the entire allelic states are expressed by integers (…, A−1, A0, A1, …) and that if an allele changes state by mutation the change occurs in such a way that it moves either one step in the positive direction or one step in the negative direction (see also Fig. 1). It was shown that for this model the ‘effective’ number of selectively neutral alleles maintained in a population of the effective size Ne under mutation rate υ per generation is given by

When 4Neυ is small, this differs little from the conventional formula by Kimura & Crow, i.e. ne = 1 + 4Neυ, but it gives a much smaller estimate than this when 4Neυ is large.

Type
Short Papers
Information
Genetics Research , Volume 22 , Issue 2 , October 1973 , pp. 201 - 204
Copyright
Copyright © Cambridge University Press 1973

References

REFERENCES

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