Hostname: page-component-78c5997874-m6dg7 Total loading time: 0 Render date: 2024-11-10T03:20:15.113Z Has data issue: false hasContentIssue false
  • English
  • Français

A new allele of the testosterone-responsive gene, Hdc-a, in the histidine decarboxylase gene complex of the mouse

Published online by Cambridge University Press:  14 April 2009

Richard J. Middleton ,
Kathleen Williamson  and
Grahame Bulfield
Richard J. Middleton
Affiliation:
Gene Expression Group, AFRC Institute of Animal Physiology and Genetics Research, Edinburgh Research Station, Roslin, Midlothian EH25 9PS, UK
Kathleen Williamson
Affiliation:
Gene Expression Group, AFRC Institute of Animal Physiology and Genetics Research, Edinburgh Research Station, Roslin, Midlothian EH25 9PS, UK
Grahame Bulfield*
Affiliation:
Gene Expression Group, AFRC Institute of Animal Physiology and Genetics Research, Edinburgh Research Station, Roslin, Midlothian EH25 9PS, UK
*
† Corresponding author.
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

In C57BL/10 and the majority of other strains of mice, females have about 20-fold higher kidney histidine decarboxylase levels than males; in DBA/2 mice, however, HDC in females is only 3- to 4-fold higher than males. The low ratio HDC phenotype of DBA/2 animals is due to decreased sensitivity of the HDC gene complex to repression by testosterone in males. From conventional crosses and by the use of the BXD recombinant inbred lines we conclude that the C57BL/ 10: DBA/2 difference, in testosterone sensitivity of HDC, is due to an allelic difference in the regulatory gene Hdc-a of the HDC gene complex, [Hdc], on chromosome 2; DBA/2 contains a third allele of this gene, Hdc-ad.

Type
Research Article
Information
Genetics Research , Volume 50 , Issue 3 , December 1987 , pp. 213 - 217
Copyright
Copyright © Cambridge University Press 1987

References

Bulfield, G. & Nahum, A. (1978). Effect of the mouse mutants Testicular feminization and Sex reversal on hormone mediated induction and repression of enzymes. Biochemical Genetics 16, 743–750.CrossRefGoogle ScholarPubMed
Grahn, B., Henningson, S., Kahlson, G. & Rosengren, E. (1973). Alterations in activities of ornithine and histidine decarboxylases provoked by testosterone in mice. British Journal Pharmacology 48, 113–120.CrossRefGoogle ScholarPubMed
Kahlson, G. & Rosengren, E. (1968). New approaches to the physiology of histamine. Physiological Reviews 48, 155–196.CrossRefGoogle Scholar
Martin, S. A. M. & Bulfield, G. (1984 a). A structural gene (Hdc-s) for mouse histidine decarboxylase. Biochemical Genetics 22, 645–655.CrossRefGoogle ScholarPubMed
Martin, S. A. M. & Bulfield, G. (1984 b). A regulatory locus, Hdc-e, determines the response of mouse kidney histidine decarboxylase to oestrogen. Biochemical Genetics 22, 1037–1046.CrossRefGoogle Scholar
Martin, S. A. M., Taylor, B. A., Watanabe, T. & Bulfield, G. (1984). Histidine decarboxylase phenotypes of inbred mouse strains: A regulatory locus (Hdc) determines kidney enzyme concentration. Biochemical Genetics 22, 305–322.CrossRefGoogle ScholarPubMed
Martin, S. A. M. & Bulfield, G. (1986). Genetic analysis of a new haplotype of the histidine decarboxylase gene complex in C57BL/6 mice. Genetical Research 47, 131–134.CrossRefGoogle ScholarPubMed
Middleton, R. J., Martin, S. A. M. & Bulfield, G. (1987). A new regulatory gene, Hdc-a, determines the responsiveness of mouse kidney histidine decarboxylase to testosterine. Genetical Research 49, 61–67.CrossRefGoogle Scholar
Pajunen, A. E., Isomaa, V. V., Janne, O. A. & Bardin, C. W. (1982). Androgenic regulatory of ornithine decarboxylase in mouse kidney and its relationship in cytosol and nuclear androgen receptor changes. Journal of Biological Chemistry 257, 8190–8198.CrossRefGoogle Scholar
Rosengren, E. (1962). Formation of histamine in the pregnant mouse. Experientia 18 (1), 176–177.CrossRefGoogle ScholarPubMed