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Association Between Mucositis Severity and Vancomycin-Resistant Enterococcal Bloodstream Infection in Hospitalized Cancer Patients

Published online by Cambridge University Press:  02 January 2015

Matthew J. Kuehnert ,
John A. Jernigan ,
Amy L. Pullen ,
David Rimland  and
William R. Jarvis
Matthew J. Kuehnert*
Affiliation:
Hospital Infections Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia
John A. Jernigan
Affiliation:
Emory University School of Medicine, Atlanta, Georgia
Amy L. Pullen
Affiliation:
Emory University School of Medicine, Atlanta, Georgia
David Rimland
Affiliation:
Emory University School of Medicine, Atlanta, Georgia
William R. Jarvis
Affiliation:
Hospital Infections Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia
*
Hospital Infections Program, Centers for Disease Control and Prevention, 1600 Clifton Rd, MS E69, Atlanta, GA 30333
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Abstract

Objective:

To determine the role of mucositis severity in the development of vancomycin-resistant enterococcal (VRE) bloodstream infection (BSI).

Setting:

A tertiary-care university medical center.

Participants:

Hematology-oncology-unit inpatients.

Design:

Patients with VRE BSI (case-patients) were compared with VRE-colonized (control) patients from September 1994 through August 1997. Oral mucositis severity was recorded on the day of VRE BSI for case-patients and on hospital day 22 (median day of hospitalization of case-patient VRE BSI) for controls. There were 19 case-patients and 31 controls.

Results:

In univariate analysis, case-patients were significantly more likely than controls to have a higher mucositis severity score, diarrhea, or a higher severity of illness score. In multivariate analysis, only mucositis remained as an independent risk factor, and increasing mucositis score was significantly associated with VRE BSI.

Conclusions:

Mucositis severity was independently associated with an increasing risk for VRE BSI. Interventions to alter mucositis severity may help to prevent VRE BSI in hospitalized cancer patients.

Type
Original Articles
Information
Infection Control & Hospital Epidemiology , Volume 20 , Issue 10 , October 1999 , pp. 660 - 663
Copyright
Copyright © The Society for Healthcare Epidemiology of America 1999

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