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Can Matrix-Assisted Laser Desorption Ionization Time-of-Flight Mass Spectrometry (MALDI-TOF) Enhance Antimicrobial Stewardship Efforts in the Acute Care Setting?

Published online by Cambridge University Press:  02 January 2015

Pranita D. Tamma ,
Kennard Tan ,
Veronique R. Nussenblatt ,
Alison E. Turnbull ,
Karen C. Carroll  and
Sara E. Cosgrove
Pranita D. Tamma*
Affiliation:
Department of Pediatrics, Division of Infectious Diseases, Johns Hopkins Medical Institutions, Baltimore, Maryland
Kennard Tan
Affiliation:
Department of Microbiology, Royal Jubilee Hospital, British Columbia, Canada
Veronique R. Nussenblatt
Affiliation:
Department of Medicine, Division of Infectious Diseases, Johns Hopkins Medical Institutions, Baltimore, Maryland
Alison E. Turnbull
Affiliation:
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland
Karen C. Carroll
Affiliation:
Department of Pathology, Division of Medical Microbiology, Johns Hopkins Medical Institutions, Baltimore, Maryland
Sara E. Cosgrove
Affiliation:
Department of Medicine, Division of Infectious Diseases, Johns Hopkins Medical Institutions, Baltimore, Maryland
*
Department of Pediatrics, Division of Infectious Diseases, Johns Hopkins Medical Institutions, 200 North Wolfe Street, Suite 3155, Baltimore, MD 21287 (ptamma1@jhmi.edu)
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Abstract

We evaluated 222 hospitalized patients whose clinical isolates were tested using standard methods and matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF). MALDI-TOF could have reduced time to appropriate therapy for 28.8% and 44.6% patients based on the treating physician's choices and stewardship team recommendations, respectively. Clinicians should be aware of scenarios in which MALDI-TOF can optimize antibiotic therapy.

Type
Concise Communication
Information
Infection Control & Hospital Epidemiology , Volume 34 , Issue 9 , September 2013 , pp. 990 - 995
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2013

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