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Chlorhexidine Use in the Neonatal Intensive Care Unit: Results from a National Survey

Published online by Cambridge University Press:  02 January 2015

Pranita D. Tamma*
Affiliation:
Division of Pediatric Infectious Diseases, Department of Pediatrics, Johns Hopkins Medical Institution, Baltimore, Maryland
Susan W. Aucott
Affiliation:
Division of Neonatology, Department of Pediatrics, Johns Hopkins Medical Institution, Baltimore, Maryland
Aaron M. Milstone
Affiliation:
Division of Pediatric Infectious Diseases, Department of Pediatrics, Johns Hopkins Medical Institution, Baltimore, Maryland
*
Johns Hopkins Medical Institution, Division of Pediatric Infectious Diseases, Department of Pediatrics, David M. Rubinstein Child Health Building, 200 N Wolfe Street, Suite 3095, Baltimore, MD 21287 (ptammal@jhmi.edu)

Abstract

Infection prevention guidelines do not endorse Chlorhexidine gluconate (CHG) use in neonates who are less than 2 months old. A survey of US neonatology program directors revealed that most neonatal intensive care units use CHG, often with some restrictions. Prospective studies are needed to further address concerns regarding the safety of CHG in patients in the neonatal intensive care unit.

Type
Concise Communcations
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2010

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References

1.Milstone, AM, Passaretti, CL, Perl, TM. Chlorhexidine: expanding the armamentarium for infection control and prevention. Clin Infect Dis 2008;46:274281.Google ScholarPubMed
2.Garland, JS, Alex, CP, Mueller, CD, et al.A randomized trial comparing povidone-iodine to a Chlorhexidine gluconate-impregnated dressing for prevention of central venous catheter infections in neonates. Pediatrics 2001;107:14311437.CrossRefGoogle ScholarPubMed
3.Mullany, LC, Darmstadt, GL, Khatry, SK, et al.Topical applications of Chlorhexidine to the umbilical cord for prevention of omphalitis and neonatal mortality in southern Nepal: a community-based, cluster-randomised trial. Lancet 2006;367:910918.CrossRefGoogle Scholar
4.Tielsch, JM, Darmstadt, GL, Mullany, LC, et al.Impact of newborn skin-cleansing with Chlorhexidine on neonatal mortality in southern Nepal: a community-based, cluster-randomized trial. Pediatrics 2007;119(2):e330e340. Epub January 8, 2007. doi:10.1542/peds.2006-1 192. Accessed January 15, 2010.CrossRefGoogle Scholar
5.Marschall, J, Mermel, LA, Classen, D, et al.SHEA/IDSA practice recommendation: strategies to prevent central line-associated bloodstream infections in acute care hospitals. Infect Control Hosp Epidemiol 2008;29:S22S306.CrossRefGoogle Scholar
6.Nachman, RL, Esterly, NB. Increased skin permeability in preterm infants. J Pediatr 1971;79:628632.CrossRefGoogle ScholarPubMed
7.Visscher, M, deCastro, MV, Combs, L, et al.Effect of Chlorhexidine gluconate on the skin integrity at PICC line sites. J Perinatol 2009;29(12):802807. Epub August 20, 2009. doi:10.1038/jp.2009.116. Accessed December 20, 2010.CrossRefGoogle ScholarPubMed
8.Cowen, J, Ellis, SH, McAinsh, J. Absorption of Chlorhexidine from the intact skin of newborn infants. Arch Dis Child 1979;54(5):379383.CrossRefGoogle ScholarPubMed
9.Wafkins, AM, Keogh, EJ. Alcohol burns in the neonate. J Paediatr Child Health 1992;28:306308.CrossRefGoogle Scholar
10.Powell, H, Swarner, O, Gluck, L, Lampert, P. Hexachlorophene myelinopathy in premature infants. J Pediatr 1973;82(6):976981.CrossRefGoogle ScholarPubMed