Hostname: page-component-cd9895bd7-dzt6s Total loading time: 0 Render date: 2024-12-28T18:21:55.126Z Has data issue: false hasContentIssue false
  • English
  • Français

Clinical Infection Control in Gene Therapy: A Multidisciplinary Conference

Published online by Cambridge University Press:  02 January 2015

Martin E. Evans ,
Craig T. Jordan ,
Stephen M.W. Chang ,
Carol Conrad ,
Julie L. Gerberding ,
Howard L. Kaufman ,
C. Glen Mayhall ,
Jan A. Nolta ,
Anne M. Pilaro  and
Sean Sullivan
...Show all authors
Martin E. Evans*
Affiliation:
Division of Infectious Diseases, University of Kentucky Medical Center, Lexington, Kentucky Chandler Medical Center, Lexington, Kentucky
Craig T. Jordan
Affiliation:
Department of Internal Medicine, University of Kentucky College of Medicine, Lexington, Kentucky
Stephen M.W. Chang
Affiliation:
Schering-Plough Research Institute and Canji, Inc, San Diego, California
Carol Conrad
Affiliation:
Division of Pediatric Pulmonology, Lucile Packard Children's Hospital at Stanford, Palo Alto, California
Julie L. Gerberding
Affiliation:
Hospital Infections Program, Centers for Disease Control and Prevention, Atlanta, Georgia
Howard L. Kaufman
Affiliation:
Albert Einstein College of Medicine of Yeshiva University, Bronx, New York
C. Glen Mayhall
Affiliation:
Division of Infectious Diseases, Department of Internal Medicine, The University of Texas Medical Branch Hospitals, Galveston, Texas
Jan A. Nolta
Affiliation:
Division of Research Immunology/BMT, Children's Hospital, Los Angeles, California
Anne M. Pilaro
Affiliation:
Food and Drug Administration/CBER, Rockville, Maryland
Sean Sullivan
Affiliation:
Valentis, Inc, The Woodlands, Texas
David J. Weber
Affiliation:
University of North Carolina Hospitals, Departments of Hospital Epidemiology and Occupational Health, Chapel Hill, North Carolina
Nelson A. Wivel
Affiliation:
Institute of Gene Therapy, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
*
Hospital Epidemiologist, Room HG608, University of Kentucky Medical Center, 800 Rose St, Lexington, KY 40536-0293
Get access Rights & Permissions [Opens in a new window]

Abstract

Gene therapy is being studied for the treatment of a variety of acquired and inherited disorders. Retroviruses, adeno-viruses, poxviruses, adeno-associated viruses, herpesviruses, and others are being engineered to transfer genes into humans. Treatment protocols using recombinant viruses are being introduced into clinical settings. Infection control professionals will be involved in reviewing the safety of these agents in their clinics and hospitals. To date, only a limited number of articles have been written on infection control in gene therapy, and no widely available recommendations exist from federal or private organizations to guide infection control professionals. The goals of the conference were to provide a forum where gene therapy experts could share their perspectives and experience with infection control in gene therapy and to provide an opportunity for newcomers to the field to learn about issues specific to infection control in gene therapy. Recommendations for infection control in gene therapy were proposed.

Type
Special Report
Information
Infection Control & Hospital Epidemiology , Volume 21 , Issue 10 , October 2000 , pp. 659 - 673
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2000

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Footnotes

*

Moderator.

†

Co-moderator.

References

1. Israel, BF, Weber, DJ, Rutala, WA. Infection control in gene therapy. In: Mayhall, CG, ed. Hospital Epidemiology and Infection Control. 2nd ed. Philadelphia, PA: Lippincott Williams & Wilkins; 1999:1015–1020.Google Scholar
2. Evans, ME, Lesnaw, JA. Infection control in gene therapy. Infect Control Hosp Epidemiol 1999;20:568–576.Google Scholar
3. Wiley, J. The Journal of Gene Therapy Website. Available from http://www.wiley.co.uk/genetherapy. New York, NY: John Wiley & Sons Ltd; 1998.Google Scholar
4. National Institutes of Health. Recombinant DNA Advisory Committee. Recombinant DNA and gene transfer. Office of Biotechnology Activities. Available from www4.od.nih.gov/oba/aboutrdagt.htm. March 29, 2000.Google Scholar
5. US Food and Drug Administration. What's new about CBER? Center for Biologies Evaluation and Research Available from http://www.fda.gov/cber/whatsnew.htm. July 25, 2000.Google Scholar
6. National Institutes of Health. Office of Biotechnology Activities. Guidelines for research involving recombinant DNA molecules. Available from www4.od.nih.gov/oba/guidelines/html. February 7, 2000.Google Scholar
7. US Food and Drug Administration. Center for Biologies Evaluation and Research. Guidance for human somatic cell therapy and gene therapy. Available from http://www.fda.gov/cber/gdlns/somgene.txt. March 1998.Google Scholar
8. Garner, JS, the Hospital Infection Control Practices Advisory Committee. Guideline for isolation precautions in hospitals. Infect Control Hosp Epidemiol 1996;17:53–80.Google Scholar
9. National Institutes of Health/Centers for Disease Control and Prevention. Biosafety in Microbiological and Biomedical Laboratories. Available from http://www.cdc.gov/od/ohs/biosfty/bmb14/bmb14toc.htm; 4th ed. Washington, DC; 1999.Google Scholar
10. Rutala, WA. APIC guideline for selection and use of disinfectants. Am J Infect Control 1996;24:313–342.Google Scholar