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Longitudinal Analysis of Endemic Gentamicin- and Tobramycin-Resistant Gram-Negative Bacilli in a Community Hospital

Published online by Cambridge University Press:  02 January 2015

C. Richard Magnussen  and
Maria T. Jacobson
C. Richard Magnussen*
Affiliation:
Department of Medicine, University of Rochester School of Medicine and Dentistry and St. Mary's Hospital, Rochester, New York
Maria T. Jacobson
Affiliation:
Department of Medicine, University of Rochester School of Medicine and Dentistry and St. Mary's Hospital, Rochester, New York
*
St. Mary's Hospital, 89 Genesee Street, Rochester, NY 14611
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Abstract

The epidemiology of endemic gentamicin- and tobramycin-resistant gram-negative bacilli at a community hospital was analyzed over a one-year period three years following an original analysis at the same hospital. The frequency and distribution of resistant organisms remained stable over the time spanning the two studies. Only 2.8% of all gram-negative bacilli were resistant to gentamicin or tobramycin, and the majority of resistant isolates were non-Enterobacteriaceae. The respiratory and urinary tracts remained the body sites most prone to harbor resistant organisms. Risk analysis using a matched comparison group again revealed prior treatment with an aminoglycoside to be the only significant factor pre-disposing to acquisition of resistant gram-negative bacilli. This analysis indicates that community hospitals may not be important reservoirs of endemic aminoglycoside-resistant gram-negative bacilli, and reconfirms the observation that each hospital must define its own pattern of aminoglycoside resistance and unique risk factors.

Type
Original Articles
Information
Infection Control & Hospital Epidemiology , Volume 5 , Issue 2 , February 1984 , pp. 88 - 92
Copyright
Copyright © The Society for Healthcare Epidemiology of America 1984

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