Hostname: page-component-cd9895bd7-dzt6s Total loading time: 0 Render date: 2024-12-28T18:40:37.115Z Has data issue: false hasContentIssue false

Successful Eradication of a Monoclonal Strain of Klebsiella pneumoniae during a K. pneumoniae Carbapenemase-Producing K. pneumoniae Outbreak in a Surgical Intensive Care Unit in Miami, Florida

Published online by Cambridge University Press:  02 January 2015

L. Silvia Munoz-Price*
Affiliation:
Division of Infectious Diseases, Department of Medicine, Miami, Florida University of Miami, and Jackson Memorial Hospital, Miami, Florida
Carolina De La Cuesta
Affiliation:
Division of Infectious Diseases, Department of Medicine, Miami, Florida University of Miami, and Jackson Memorial Hospital, Miami, Florida
Stephen Adams
Affiliation:
University of Miami, and Jackson Memorial Hospital, Miami, Florida
Mary Wyckoff
Affiliation:
Department of Surgery, Miami, Florida University of Miami, and Jackson Memorial Hospital, Miami, Florida
Timothy Cleary
Affiliation:
Department of Pathology, Miami, Florida
Sandra P. McCurdy
Affiliation:
Pfizer Global Research and Development, Groton, Connecticut, Rush University Medical Center, Chicago, Illinois
Michael D. Huband
Affiliation:
Pfizer Global Research and Development, Groton, Connecticut, Rush University Medical Center, Chicago, Illinois
M. Megan Lemmon
Affiliation:
Pfizer Global Research and Development, Groton, Connecticut, Rush University Medical Center, Chicago, Illinois
MaryKay Lescoe
Affiliation:
Pfizer Global Research and Development, Groton, Connecticut, Rush University Medical Center, Chicago, Illinois
Fadia B. Dibhajj
Affiliation:
Pfizer Global Research and Development, Groton, Connecticut, Rush University Medical Center, Chicago, Illinois
Mary K. Hayden
Affiliation:
Department of Pathology, Rush University Medical Center, Chicago, Illinois Section of Infectious Diseases, Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois
Karen Lolans
Affiliation:
Department of Pathology, Rush University Medical Center, Chicago, Illinois
John P. Quinn
Affiliation:
Pfizer Global Research and Development, Groton, Connecticut, Rush University Medical Center, Chicago, Illinois
*
Jackson Memorial Hospital, Park Plaza West L-302, 1611 NW 12th Avenue, Miami, FL 33136-1096, (smunozprice@med.miami.edu)

Extract

We describe the investigation and control of a Klebsiella pneumoniae carbapenemase-producing K. pneumoniae outbreak in a 20-bed surgical intensive care unit during the period from January 1, 2009 through January 1, 2010. Nine patients were either colonized or infected with a monoclonal strain of K. pneumoniae. The implementation of a bundle of interventions on July 2009 successfully controlled the further horizontal spread of this organism.

Type
Concise Communications
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2010

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1.Nordmann, P, Cuzon, G, Naas, T. The real threat of Klebsiella pneumoniae carbapenemase-producing bacteria. Lancet Infect Dis 2009;9:228236.CrossRefGoogle ScholarPubMed
2.Patel, G, Huprikar, S, Factor, SH, Jenkins, SG, Calfee, DP. Outcomes of carbapenem-resistant Klebsiella pneumoniae infection and the impact of antimicrobial and adjunctive therapies. Infect Control Hosp Epidemiol 2008;29:10991106.Google Scholar
3.Gasink, LB, Edelstein, PH, Lautenbach, E, Synnestvedt, M, Fishman, NO. Risk factors and clinical impact of Klebsiella pneumoniae carbapenemaseproducing K. pneumoniae. Infect Control Hosp Epidemid 2009;30:11801185.Google Scholar
4.Clinical Laboratory Standards Institute (CLSI). Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically: approved standard. CLSI document M07-A8. 8th ed. Wayne, PA: CLSI; 2009.Google Scholar
5.Clinical Laboratory Standards Institute (CLSI). Performance standards for antimicrobial susceptibility testing: 19th informational supplement. CLSI document M100-S19. Wayne, PA: CLSI; 2009.Google Scholar
6.Tenover, FC, Arbeit, RD, Goering, RV, et al.Interpreting chromosomal DNA restriction patterns produced by pulsed-field gel electrophoresis: criteria for bacterial strain typing. J Clin Microbiol 1995;33:22332239.Google Scholar
7.Lolans, K, Calvert, K, Won, S, Clark, J, Hayden, MK. Direct ertapenem disk screening method for identification of KPC-producing Klebsiella pneumoniae and Escherichia coli in surveillance swab specimens. J Clin Microbiol 2010;48:836841.Google Scholar
8.Kochar, S, Sheard, T, Sharma, R, et al. Success of an infection control program to reduce the spread of carbapenem-resistant Klebsiella pneumoniae. Infect Control Hosp Epidemiol 2009;30:447452.CrossRefGoogle ScholarPubMed
9.Munoz-Price, LS, Hayden, MK, Lolans, K, et al.Successful control of an outbreak of Klebsiella pneumoniae carbapenemase-producing K. pneumoniae at a long-term acute care hospital. Infect Control Hosp Epidemiol 2010;31:341347.Google Scholar
10. Centers for Disease Control and Prevention (CDC). Guidance for control of infections with carbapenem-resistant or carbapenemase-producing En-terobacteriaceae in acute care facilities. MMWR Morb Mortal Wkly Rep 2009;58:256260.Google Scholar
11.Leavitt, A, Navon-Venezia, S, Chmelnitsky, I, Schwaber, MJ, Carmeli, Y. Emergence of KPC-2 and KPC-3 in carbapenem-resistant Klebsiella pneumoniae strains in an Israeli hospital. Antimicrob Agents Chemother 2007;51:30263029.CrossRefGoogle Scholar
12.Bratu, S, Landman, D, Haag, R, et al.Rapid spread of carbapenem-resistant Klebsiella pneumoniae in New York City: a new threat to our antibiotic armamentarium. Arch Intern Med 2005;165:14301435.Google Scholar
13.Munoz-Price, LS, Quinn, JP. The spread of Klebsiella pneumoniae car-bapenemases: a tale of strains, plasmids, and transposons. Clin Infect Dis 2009;49:17391741.Google Scholar
14.Srinivasan, A, Patel, JB. Klebsiella pneumoniae carbapenemase-producing organisms: an ounce of prevention really is worth a pound of cure. Infect Control Hosp Epidemiol 2008;29:11071109.Google Scholar
15. Research Committee of the Society of Healthcare Epidemiology of America. SHEA position paper. Enhancing patient safety by reducing healthcare-associated infections: the role of discovery and dissemination. Infect Control Hosp Epidemiol 2010;31:118123.Google Scholar