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Ten-Year Persistence of Antibody to Hepatitis B Surface Antigen in Healthcare Workers Vaccinated Against Hepatitis B Virus, and Response to Booster Vaccination

Published online by Cambridge University Press:  02 January 2015

Ricardo Durlach*
Affiliation:
German Hospital, Buenos Aires, Argentina
Stella Laugas
Affiliation:
German Hospital, Buenos Aires, Argentina
Cristina B. Freuler
Affiliation:
German Hospital, Buenos Aires, Argentina
Viviana E. Rodríguez
Affiliation:
German Hospital, Buenos Aires, Argentina
Marta Costa
Affiliation:
German Hospital, Buenos Aires, Argentina
*
Avenida Pueyrredon 1640, (1118) Ciudad de Buenos Aires, Argentina

Abstract

This study estimated the number of HCWs with protective antibody levels 5 and 10 years after HBV vaccination. Kaplan-Meier probabilities of protective levels were 0.95 at 60 days after vaccination, 0.87 at 5 years, and 0.79 at 10 years. Those without protective levels displayed good response 7 and 30 days after a booster

Type
Concise Communications
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2003

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References

1.Center for Disease Control. Hepatitis B virus: a comprehensive strategy for eliminating transmission in the United States through universal childhood vaccination. Recommendations of the Immunization Practices Advisory Committee (ACIP). MMWR 1991;40(RR-13):119.Google Scholar
2.Hadler, SC, Margolis, HS. Viral hepatitis. In: Evans, AS, ed. Viral Infections of Humans, 3rd ed. New York: Plenum; 1991:351391.CrossRefGoogle Scholar
3.Wu, JS, Hwang, LY, Goodman, KS, Beasley, RP. Hepatitis B vaccination in high-risk infants: 10 years follow-up. J Infect Dis 1999;179:13191325.CrossRefGoogle Scholar
4.European Consensus Group on Hepatitis B Immunity. Are booster immunizations needed for lifelong hepatitis B immunity? Lancet 2000;355:561565.CrossRefGoogle Scholar
5.Jilg, W, Schmidt, M, Deinhart, F. Four-year experience with a recombinant hepatitis B vaccine. Infection 1989;17:7076.CrossRefGoogle ScholarPubMed
6.Barash, C, Conn, MI, Di Marino, AJ, Marzano, J, Allen, M. Serologic hepatitis B immunity in vaccinated health care workers. Arch Intern Med 1999;159:14811483.CrossRefGoogle ScholarPubMed
7.Van Herck, K, Van Damme, P, Thoelen, S, Meheus, A. Long-term persistence of anti-HBs after vaccination with a recombinant DNA yeast-derived hepatitis B vaccine: 8 years results. Vaccine 1998;16:19331935.CrossRefGoogle Scholar
8.Jilg, W, Schmidt, M, Dienhardt, F. Persistence of specific antibodies after hepatitis B vaccination. J Hepatol 1988;6:201207.CrossRefGoogle ScholarPubMed
9.AIDS/TB Committee of the Society for Healthcare Epidemiology of America. Management of healthcare workers infected with hepatitis B virus, hepatitis C virus, human immunodeficiency virus or other bloodborne pathogens. Infect Control Hosp Epidemiol 1997;18:349363.CrossRefGoogle Scholar
10.Catterall, AP, Murray-Lyon, MI. Strategies for hepatitis B immunization. Gut 1992;33:576579.CrossRefGoogle Scholar
11.Koziol, DE, Henderson, DK. Nosocomial viral hepatitis in health care workers. In: Mayhall, CG, ed. Hospital Epidemiology and Infection Control, 2nd ed. Philadelphia: Lippincott Williams & Wilkins; 1999:10571073.Google Scholar
12.Ni, YH, Chang, MH, Huang, LM, et al.Hepatitis B virus infection in children and adolescents in a hyperendemic area: 15 years after mass hepatitis B vaccination. Ann Intern Med 2001;135:796800.CrossRefGoogle Scholar
13.McMahon, BJ, Hoick, P, Bulkow, L, Snowball, M. Serologic and clinical outcomes of 1536 Alaska natives chronically infected with hepatitis B virus. Ann Intern Med 2001;135:759768.CrossRefGoogle ScholarPubMed
14.Da Villa, G, Peluso, F, Picciotto, L, Bencivenga, M, Elia, S, Pelliccia, MG. Persistence of anti-HBs in children vaccinated against viral hepatitis B in the first year of life: follow-up at 5 and 10 years. Vaccine 1996;14:15031505.CrossRefGoogle ScholarPubMed
15.Laugas, S, Freuler, CB, Rodriguez, VE, Durlach RA Antibody level of hepatitis B after 10 years vaccination. Presented at the 4th Decennial International Conference on Nosocomial and Healthcare Associated Infections; March 5-9, 2000; Atlanta, GAGoogle Scholar
16.Wismans, PJ, van Hartum, J, Mudde, GC, Endeman, HJ, Poel, J, de Gast, GC. Is booster injection with hepatitis B vaccine necessary in healthy responders? A study of the immune response. J Hepatol 1989;8:236240.CrossRefGoogle ScholarPubMed
17.Wainwright, RB, Bulkow, LR, Parkinson, AJ, Zanis, C, McMahon, BJ. Protection provided by hepatitis B vaccine in a Yupik Eskimo population: results of a 10-year study. J Infect Dis 1997;175:674677.CrossRefGoogle Scholar