Hostname: page-component-cd9895bd7-gvvz8 Total loading time: 0 Render date: 2024-12-28T18:32:44.309Z Has data issue: false hasContentIssue false
  • English
  • Français

Toward New Biomaterials

Published online by Cambridge University Press:  02 January 2015

Béatrice Montdargent  and
Didier Letourneur
Béatrice Montdargent
Affiliation:
Laboratoire de Recherches sur les Macromolécules, Institut Galilée, Villetaneuse, France
Didier Letourneur*
Affiliation:
Laboratoire de Recherches sur les Macromolécules, Institut Galilée, Villetaneuse, France
*
Institut Galilée, Universite Paris 13, CNRS UMR 7540, 99 Av JB Clement, 93430 Villetaneuse, France
Get access Rights & Permissions [Opens in a new window]

Abstract

Polymers are widely used for a large range of medical devices used as biomaterials on a temporary, intermittent, and long-term basis. It is now well accepted that the initial rapid adsorption of proteins to polymeric surfaces affects the performance of these biomaterials. However, protein adsorption to a polymer surface can be modulated by an appropriate design of the interface. Extensive study has shown that these interactions can be minimized by coating with a highly hydrated layer (hydrogel), by grafting on the surface different biomolecules, or by creating domains with chemical functions (charges, hydrophilic groups). Our laboratory has investigated the latter approach over the past 2 decades, in particular the synthesis and the biological activities of polymers to improve the biocompatibility of blood-contacting devices. These soluble and insoluble polymers were obtained by chemical substitution of macromolecular chains with suitable groups able to develop specific interactions with biological components. Applied to compatibility with the blood and the immune systems, this concept has been extended to interactions of polymeric biomaterials with eukaryotic and prokaryotic cells. The design of new biomaterials with low bacterial attachment is thus under intensive study. After a brief overview of current trends in the surface modifications of biocompatible materials, we will describe how biospecific polymers can be obtained and review our recent results on the inhibition of bacterial adhesion using one type of functionalized polymer obtained by random substitution. This strategy, applied to existing or new materials, seems promising for the limitation of biomaterial-associated infections.

Type
Reviews
Information
Infection Control & Hospital Epidemiology , Volume 21 , Issue 6 , June 2000 , pp. 404 - 410
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2000

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1. Andrade, JD. Needs, problems, and opportunities in biomaterials and biocompatibility. Clin Mater 1992;11:19–23.Google Scholar
2. Courtney, JM, Lamba, NM, Sundaram, S, Forbes, CD. Biomaterials for blood-contacting applications. Biomaterials 1994;15:737–744.Google Scholar
3. Ratner, BD. Characterization of biomaterials surfaces. Cardiovasc Pathol 1993;2:87–100.CrossRefGoogle Scholar
4. Jacobs, H, Grainger, D, Okano, T, Kim, SW. Surface modification for improved blood compatibility. Artif Organs 1988;12:506–507.Google Scholar
5. Rubens, FD, Weitz, JI, Brash, JL, Kinlough-Rathbone, RL. The effect of antithrombin III—independent thrombin inhibitors and heparin on fibrin accretion onto fibrin-coated polyethylene. Thromb Haemost 1993;69:130–134.Google Scholar
6. Hsu, LC. Biocompatibility in heparin-coated extracorporeal circuits. Perfusion 1996;11:256–263.CrossRefGoogle ScholarPubMed
7. Okkema, AZ, Yu, XH, Cooper, SL. Physical and blood contacting characteristics of propyl sulphonate grafted Biomer. Biomaterials 1991;12:3–10.Google Scholar
8. Skarja, GA, Brash, JL. Physicochemical properties and platelet interactions of segmented polyurethanes containing sulfonate groups in the hard segment. J Biomed Mater Res 1997;34:439–455.Google Scholar
9. Ratner, BD. Plasma deposition for biomedical applications: a brief review. J Biomater Sci Polym Edn 1992;4:3–11.Google Scholar
10. Ito, Y. Surface micropatterning to regulate cell functions. Biomaterials 1999;20:2333–2342.Google Scholar
11. Hubbell, JA. Bioactive biomaterials. Curr Opin Biotechnol 1999;10:123–129.Google Scholar
12. Jozefowicz, M, Jozefonvicz, J. Randomness and biospecificity: random copolymers are capable of biospecific molecular recognition in living systems. Biomaterials 1997;18:1633–1644.CrossRefGoogle ScholarPubMed
13. Brash, JL, Ten Hove, P. Protein adsorption studies on ‘standard’ polymeric materials. J Biomater Sci Polym Edn 1993;4:591–599.Google Scholar
14. Wojciechowski, P, Brash, JL. The Vroman effect in tube geometry: the influence of flow on protein adsorption measurements. J Biomater Sci Polym Edn 1991;2:203–216.CrossRefGoogle ScholarPubMed
15. Glantz, PO, Arnebrant, T, Nylander, T, Baier, RE. Bioadhesion—a phenomenon with multiple dimensions. Acta Odontol Scand 1999;57:238–241.Google ScholarPubMed
16. Courtney, JM, Lamba, NM, Sundaram, S, Forbes, CD. Biomaterials for blood-contacting applications. Biomaterials 1994;15:737–744.Google Scholar
17. Brash, JL, Scott, CF, ten Hove, P, Wojciechowski, P, Colman, RW. Mechanism of transient adsorption of fibrinogen from plasma to solid surfaces: role of the contact and fibrinolytic systems. Blood 1988;71:932–929.CrossRefGoogle ScholarPubMed
18. Yung, LY, Colman, RW, Cooper, SL. The effect of high molecular weight kininogen on neutrophil adhesion to polymer surfaces. Immuno-pharmacology 1999;43:281–286.CrossRefGoogle ScholarPubMed
19. Cornelius, RM, Brash, JL. Adsorption from plasma and buffer of single-and two-chain high molecular weight kininogen to glass and sulfonated polyurethane surfaces. Biomaterials 1999;20:341–350.Google Scholar
20. Hoffman, AS. Non-fouling surface technologies. J Biomater Sci Polym Edn 1999;10:1011–1014.Google Scholar
21. Peppas, NA, Sahlin, JJ. Hydrogels as mucoadhesive and bioadhesive materials: a review. Biomaterials 1996;17:1553–1561.Google Scholar
22. Amiji, M, Park, K. Surface modification of polymeric biomaterials with poly(ethylene oxide), albumin, and heparin for reduced thrombogenicity. J Biomater Sci Polym Edn 1993;4:217–234.Google Scholar
23. Leckband, D, Sheth, S, Halperin, A. Grafted poly (ethylene oxide) brushes as nonfouling surface coatings. J Biomater Sci Polym Edn 1999;10:1125–1147.CrossRefGoogle ScholarPubMed
24. West, JL, Hubbell, JA. Separation of the arterial wall from blood contact using hydrogel barriers reduces intimal thickening after balloon injury in the rat: the roles of medial and luminal factors in arterial healing. Proc Natl Acad Sci USA 1996;93:13188–13193.CrossRefGoogle ScholarPubMed
25. An, Y, Hubbell, JA. Intraarterial protein delivery via intimally-adherent Mayer hydrogels. J Controlled Release 2000;64:205–215.Google Scholar
26. Healy, KE, Rezania, A Stile, RA. Designing biomaterials to direct biological responses. Ann N Y Acad Sci 1999;875:24–35.Google Scholar
27. Sakiyama, SE, Schense, JC, Hubbell, JA. Incorporation of heparin-binding peptides into fibrin gels enhances neurite extension: an example of designer matrices in tissue engineering. FASEB J 1999;13:2214–2224.Google Scholar
28. Sun, X, Sheardown, H, Tengvall, R, Brash, JL. Peptide modified gold-coated polyurethanes as thrombin scavenging surfaces. J Biomed Mater Res 2000;49:66–78.Google Scholar
29. Stanislawski, L, Serne, H, Stanislawski, M, Jozefowicz, M. Conformational changes of fibronectin induced by polystyrene derivatives with a heparin-like function. J Biomed Mater Res 1993;27:619–626.Google Scholar
30. McClung, WG, Clapper, DL, Hu, SP, Brash, JL. Adsorption of plasminogen from human plasma to lysine-containing surfaces. J Biomed Mater Res 2000;49:409–414.Google Scholar
31. Werner, C, Jacobasch, HJ. Surface characterization of polymers for medical devices. Int J Artif Organs 1999;22:160–176.Google Scholar
32. Siedlecki, CA, Marchant, RE. Atomic force microscopy for characterization of the biomaterial interface. Biomaterials 1998;19:441–454.Google Scholar
33. Tengvall, P, Lundstrom, I, Liedberg, B. Protein adsorption studies on model organic surfaces: an ellipsometric and infrared spectroscopic approach. Biomaterials 1998;19:407–422.Google Scholar
34. Chittur, KK. FTIR/ATR for protein adsorption to biomaterial surfaces. Biomaterials 1998;19:357–369.Google Scholar
35. Suci, PA, Vrany, JD, Mittelman, MW. Investigation of interactions between antimicrobial agents and bacterial biofilms using attenuated total reflection Fourier transform infrared spectroscopy. Biomaterials 1998;19:327–339.Google Scholar
36. An, YH, Friedman, RJ. Animal models of orthopedic implant infection. J Invest Surg 1998;11:139–146.Google Scholar
37. Reid, G. Applications from bacterial adhesion and biofilm studies in relation to urogenital tissues and biomaterials: a review. J Ind Microbiol 1994;13:90–96.Google Scholar
38. Hudson, MC, Ramp, WK, Frankenburg, KP. Staphylococcus aureus adhesion to bone matrix and bone-associated biomaterials. FEMS Microbiol Lett 1999;173:279–284.Google Scholar
39. Zoutman, D, Chau, L, Watterson, J, Mackenzie, T, Djurfeldt, M. A Canadian survey of prophylactic antibiotic use among hip-fracture patients. Infect Control Hosp Epidemiol 1999;20:752–755.CrossRefGoogle ScholarPubMed
40. Burrows, LL, Khoury, AE. Issues surrounding the prevention and management of device-related infections. World J Urol 1999;17:402–409.Google Scholar
41. An, YH, Friedman, RJ. Concise review of mechanisms of bacterial adhesion to biomaterial surfaces. J Biomed Mater Res 1998;43:338–348.Google Scholar
42. Vaudaux, P, Yasuda, H, Velazco, MI, Huggler, E, Ratti, I, Waldvogel, FA, et al. Role of host and bacterial factors in modulating staphylococcal adhesion to implanted polymer surfaces. J Biomater Appl 1990;5:134–153.Google Scholar
43. Wadstrom, T. Molecular aspects of bacterial adhesion, colonization, and development of infections associated with biomaterials. J Invest Surg 1989;2:353–360.CrossRefGoogle ScholarPubMed
44. Spencer, RC. Novel methods for the prevention of infection of intravascular devices. J Hosp Infect 1999;43:S127–S135.Google Scholar
45. Bach A Prevention of infections caused by central venous catheters-established and novel measures. Infection 1999;27:S11–S15.Google Scholar
46. Raad, I, Hanna, H. Intravascular catheters impregnated with antimicrobial agents: a milestone in the prevention of bloodstream infections. Support Care Cancer 1999;7:386–390.CrossRefGoogle ScholarPubMed
47. Darouiche, RO, Raad, II, Heard, SO, Thornby, JI, Wenker, OC, Gabrielli, A, et al. A comparison of two antimicrobial-impregnated central venous catheters. Catheter Study Group. N Engl J Med 1999;340:1–8.Google Scholar
48. Gupta, A, Matsui, K, Lo, JF, Silver, S. Molecular basis for resistance to silver cations in Salmonella . Nat Med 1999;5:183–188.Google Scholar
49. Flemming, RG, Capelli, CC, Cooper, SL, Proctor, RA. Bacterial colonization of functionalized polyurethanes. Biomaterials 2000;21:273–281.Google Scholar
50. John, SF, Derrick, MR, Jacob, AE, Handley, PS. The combined effects of plasma and hydrogel coating on adhesion of Staphylococcus epidermidis and Staphylococcus aureus to polyurethane catheters. FEMS Microbiol Lett 1996;144:241–247.Google Scholar
51. Rojas, IA, Slunt, JB, Grainger, DW. Polyurethane coatings release bioactive antibodies to reduce bacterial adhesion. J Controlled Release 2000;63:175–189.Google Scholar
52. Migonney, V, Fougnot, C, Jozefowicz, M. Heparin-like tubings. Biomaterials 1988;9:145–149.Google Scholar
53. Migonney, V, Souirti, A, Jozefowicz, M. Biospecific interactions of vitamin K—dependent factors with phospholipid-like polystyrene derivatives, part II: factor DC. Biomaterials 1997;18:1077–1084.Google Scholar
54. Crepon, B, Maillet, F, Kazatchkine, MD, Jozefonvicz, J. Molecular weight dependency of the acquired anticomplementary and anticoagulant activities of specifically substituted dextrans. Biomaterials 1987;8:248–253.Google Scholar
55. Thomas, H, Maillet, F, Letourneur, D, Jozefonvicz, J, Kazatchkine, MD. Effect of substituted dextran derivative on complement activation in vivo. Biomaterials 1995;16:1163–1167.Google Scholar
56. Letourneur, D, Jozefowicz, M. Insoluble DNA-like phosphorylated polystyrene: specific interactions with anti-DNA antibodies from systemic lupus erythematosus patients. Biomaterials 1992;13:59–63.Google Scholar
57. Migonney, V, Souirti, A, Pavon-Djavid, G, Ravion, O, Pfluger, F, Jozefowicz, M. Biospecific polymers: recognition of phosphorylated polystyrene derivatives by anti-DNA antibodies. J Biomater Sci Polym Edn 1997;8:533–544.Google Scholar
58. Imbert, E, Letourneur, D, Jozefowicz, M. Fractionation of RNA polymerase II transcription factors from HeLa cell nuclear extracts by affinity chromatography on “DNA-like” phosphorylated polystyrene. J Chromatogr B Biomed Sci App 1997;698:59–68.Google Scholar
59. Cornelius, RM, Dahri, L, Boisson-Vidal, C, Muller, D, Jozefonvicz, J, Brash, JL. Adsorption of immunoglobulin G and anti-factor VIII inhibitory antibody from haemophiliac plasma to derivatized polystyrenes. Biomaterials 1997;18:429–436.Google Scholar
60. Bagheri-Yarmand, R, Morere, JF, Letourneur, D, Jozefonvicz, J, Israel, L, Crepin, M. Inhibitory effects of dextran derivatives in vitro on the growth characteristics of premalignant and malignant human mammary epithelial cell lines. Anticancer Res 1992;12:1641–1646.Google Scholar
61. Chaubet, F, Huynh, R, Champion, J, Jozefonvicz, J, Letourneur, D. Sulphated polysaccharides derived from dextran. Biomaterials for vascular therapy. Polym Int 1999;48:313–319.Google Scholar
62. Tardieu, M, Gamby, C, Avramoglou, T, Jozefonvicz, J, Barritault, D. Derivatized dextrans mimic heparin as stabilizers, potentiators, and protectors of acidic or basic FGF. J Cell Physiol 1992;150:194–203.CrossRefGoogle ScholarPubMed
63. Letourneur, D, Logeart, D, Avramoglou, T, Jozefonvicz, J. Antiproliferative capacity of synthetic dextrans on smooth muscle cell growth: the model of derivatized dextrans as heparin-like polymers. J Biomater Sci Polym Edn 1993;4:431–444.Google Scholar
64. Logeart, D, Letourneur, D, Jozefonvicz, J, Kern, P. Collagen synthesis by vascular smooth muscle cells in the presence of antiproliferative polysaccharides. J Biomed Mater Res 1996;30:501–508.Google Scholar
65. Seras-Cansell, M, Sahli, H, Dubois, V, Letourneur, D, Jozefonvicz, J. Characterization of vesicles for vascular cell targeting: influence of dextran coating. In: Ottenbrite, R, ed. Frontiers in Biomedical Polymer Applications, vol. 1. Lancaster, PA: Technomic Publishing Co; 1998:95–108.Google Scholar
66. Cansell, M, Parisei, C, Jozefonvicz, J, Letourneur, D. Liposomes coated with chemically modified dextran interact with human endothelial cells. J Biomed Mater Res 1999;44:140–148.Google Scholar
67. Blondin, C, Bataille, I, Letourneur, D. Polysaccharides for vascular cell targeting. Crit Rev Ther Drug Carrier Syst. In press.Google Scholar
68. Cansell, M, Letourneur, D. Liposomes coated with bioactive polysaccharides for use as drug delivery systems. In: Wise, DL, ed. Biomaterials. New York City, NY: M. Dekker; 2000:337–354.Google Scholar
69. Clairbois, AS, Letourneur, D, Muller, D, Jozefonvicz, J. High-performance affinity chromatography for the purification of heparin-binding proteins from detergent-solubilized smooth muscle cell membranes. J Chromatogr B Biomed Sci App 1998;706:55–62.Google Scholar
70. Clairbois, AS, Letourneur, D, Muller, D, Jozefonvicz, J. Heparin grafted silica beads for high performance affinity chromatography of proteins from smooth muscle cell membranes. Inter J Biochrotn 1998;4:1–13.Google Scholar
71. Migonney, V, Lacroix, MD, Ratner, BD, Jozefowicz, M. Silicone derivatives for contact lenses: functionalization, chemical characterization, and cell compatibility assessment. J Biomater Sci Polym Edn 1995;7:265–275.Google Scholar
72. Logeart-Avramoglou, D, Jozefonvicz, J. Carboxymethyl benzylamide sulfonate dextrans (CMDBS), a family of biospecific polymers endowed with numerous biological properties: a review. J Biomed Mater Res 1999;48:578–590.Google Scholar
73. Vaudaux, P, Avramoglou, T, Letourneur, D, Lew, DR, Jozefonvicz, J. Inhibition by heparin and derivatized dextrans of Staphylococcus aureus adhesion to fibronectin-coated biomaterials. J Biomater Sci Polym Edn 1992;4:89–97.CrossRefGoogle ScholarPubMed
74. Francois, P, Letourneur, D, Lew, DP, Jozefonvicz, J, Vaudaux, P. Inhibition by heparin and derivatized dextrans of Staphylococcus epidermidis adhesion to in vitro fibronectin-coated or explanted polymer surfaces. J Biomater Sci Polym Edn 1999;10:1207–1221.CrossRefGoogle ScholarPubMed
75. de Raucourt, E, Mauray, S, Chaubet, F, Maiga-Revel, O, Jozefowicz, M, Fischer, AM. Anticoagulant activity of dextran derivatives. J Biomed Mater Res 1998;41:49–57.Google Scholar
76. Neyts, J, Reymen, D, Letourneur, D, Jozefonvicz, J, Schols, D, Este, J, et al. Differential antiviral activity of derivatized dextrans. Biochem Pharmacol 1995;50:743–751.Google Scholar
77. Carre, V, Mbemba, E, Letourneur, D, Jozefonvicz, J, Gattegno, L. Interactions of HIV-1 envelope glycoproteins with derivatized dextrans. Biochim Biophys Acta 1995;1243:175–180.Google Scholar
78. Seddiki, N, Mbemba, E, Letourneur, D, Ylisastigui, L, Benjouad, A, Saffar, L, et al. Antiviral activity of derivatized dextrans on HIV-1 infection of primary macrophages and blood lymphocytes. Biochim Biophys Acta 1997;1362:47–55.CrossRefGoogle ScholarPubMed
79. Thomas, H, Maillet, F, Letourneur, D, Jozefonvicz, J, Fischer, E, Kazatchkine, MD. Sulfonated dextran inhibits complement activation and complement-dependent cytotoxicity in an in vitro model of hyperacute xenograft rejection. Mol Immunol 1996;33:643–648.Google Scholar
80. Prigent-Richard, S, Cansell, M, Vassy, J, Viron, A, Puvion, E, Jozefonvicz, J, et al. Fluorescent and radiolabeling of polysaccharides', binding and internalization experiments on vascular cells. J Biomed Mater Res 1998;40:275–281.Google Scholar
81. Letourneur, D, Champion, J, Slaoui, F, Jozefonvicz, J. In vitro stimulation of human endothelial cells by derivatized dextrans. In Vitro Cell Dev Biol 1993;29:67–72.Google Scholar
82. Bagheri-Yarmand, R, Kourbali, Y, Rath, AM, Vassy, R, Martin, A, Jozefonvicz, J, et al. Carboxymethyl benzylamide dextran blocks angiogenesis of MDA-MB435 breast carcinoma xenografted in fat pad and its lung metastases in nude mice. Cancer Res 1999;59:507–510.Google Scholar
83. Bittoun, P, Bagheri-Yarmand, R, Chaubet, F, Crepin, M, Jozefonvicz, J, Fermandjian, S. Effects of the binding of a dextran derivative on fibroblast growth factor 2: secondary structure and receptor-binding studies. Biochem Pharmacol 1999;57:1399–1406.Google Scholar
84. Bagheri-Yarmand, R, Kourbali, Y, Morere, JF, Jozefonvicz, J, Crepin, M. Inhibition of MCF-7ras tumor growth by carboxymethyl benzylamide dextran: blockage of the paracrine effect and receptor binding of transforming growth factor beta 1 and platelet-derived growth factor-BB. Cell Growth Differ 1998;9:497–504.Google Scholar
85. Bagheri-Yarmand, R, Kourbali, Y, Mabilat, C, Morere, JF, Martin, A, Lu, H, et al. The suppression of fibroblast growth factor 2/fibroblast growth factor 4-dependent tumour angiogenesis and growth by the anti-growth factor activity of dextran derivative (CMDB7). Br J Cancer 1998,78:111–118.CrossRefGoogle ScholarPubMed
86. Vaudaux, P, Lew, DP, Waldvogel, FA. Host factors predisposing to and influencing therapy of foreign body infections. In: Bisno, AL, Waldvogel, FA, eds. Infections Associated With Indwelling Medical Devices. 2nd ed. Washington, DC: American Society for Microbiology; 1994:1–29.Google Scholar
87. Francois, P, Schrenzel, J, Stoerman-Chopard, C, Favre, H, Herrmann, M, Foster, TJ, et al. Identification of plasma proteins adsorbed on hemodialysis tubing that promote Staphylococcus aureus adhesion. J Lab Clin Med 2000;135:32–42.Google Scholar
88. Yamada, KM, Fibronectin domains and receptors. In: Mosher, DF, ed. Fibronectin. San Diego, CA Academic Press; 1989:48–121.Google Scholar