No CrossRef data available.
Article contents
An outbreak of severe acute respiratory coronavirus virus 2 (SARS-CoV-2) infections among hospital personnel with high mRNA vaccine uptake
Part of:
SARS-CoV-2/COVID-19
Published online by Cambridge University Press: 20 September 2021
Abstract
Real-world studies have demonstrated impressive effectiveness of the BNT162b2 COVID-19 vaccine in preventing symptomatic and asymptomatic SARS-CoV-2 infection. We describe an outbreak of SARS-CoV-2 infections in a hospital with high vaccine uptake. We found a low secondary attack rate (7%), suggesting low infectivity of vaccinated persons with vaccine breakthrough SARS-CoV-2 infections.
- Type
- Concise Communication
- Information
- Copyright
- © The Author(s), 2021. Published by Cambridge University Press on behalf of The Society for Healthcare Epidemiology of America
References
Polack, FP, Thomas, SJ, Kitchin, N, et al. Safety and efficacy of the BNT162b2 mRNA COVID-19 vaccine. N Engl J Med 2020;383:2603–2615.CrossRefGoogle ScholarPubMed
Dagan, N, Barda, N, Kepten, E, et al. BNT162b2 mRNA COVID-19 vaccine in a nationwide mass vaccination setting. N Engl J Med 2021;384:1412–1423.CrossRefGoogle Scholar
Yanes-Lane, M, Winters, N, Fregonese, F, et al. Proportion of asymptomatic infection among COVID-19 positive persons and their transmission potential: a systematic review and meta-analysis. PLoS One 2020;15(11):e0241536.CrossRefGoogle ScholarPubMed
Levine-Tiefenbrun, M, Yelin, I, Katz, R, et al. Initial report of decreased SARS-CoV-2 viral load after inoculation with the BNT162b2 vaccine. Nat Med 2021;27:790–792.CrossRefGoogle ScholarPubMed
Shah, A GC, Bishop, J, Hanlon, P, et al. Effect of vaccination on transmission of COVID-19: an observational study in healthcare workers and their households. N Engl J Med 2021. doi: 10.1056/NEJMc2106757.Google Scholar
Angel, Y, Spitzer, A, Henig, O, et al. Association between vaccination with BNT162b2 and incidence of symptomatic and asymptomatic SARS-CoV-2 infections among healthcare workers. JAMA 2021;325:2457–2465.CrossRefGoogle Scholar
COVID-19 contact tracing communications toolkit for health departments. Centers for Disease Control and Prevention website. https://wwwcdc.gov/coronavirus/2019-ncov/php/contact-tracing-commshtml. Accessed June 4, 2021.Google Scholar
Madewell, ZJ, Yang, Y, Longini, IM Jr, Halloran, ME, Dean, NE. Household transmission of SARS-CoV-2: a systematic review and meta-analysis. JAMA Netw Open 2020;3(12):e2031756.CrossRefGoogle ScholarPubMed
Walsh, KA, Jordan, K, Clyne, B, et al. SARS-CoV-2 detection, viral load and infectivity over the course of an infection. J Infect 2020;81:357–371.CrossRefGoogle ScholarPubMed
Munitz, A, Yechezkel, M, Dickstein, Y, Yamin, D, Gerlic, M. BNT162b2 vaccination effectively prevents the rapid rise of SARS-CoV-2 variant B.1.1.7 in high-risk populations in Israel. Cell Rep Med 2021;2(5):100264.CrossRefGoogle ScholarPubMed