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The Antibiotic Development Pipeline for Multidrug-Resistant Gram-Negative Bacilli: Current and Future Landscapes

Published online by Cambridge University Press:  02 January 2015

George H. Talbot
George H. Talbot*
Affiliation:
Talbot Advisors LLC, Wayne, Pennsylvania
*
PO Box 7440, St. Davids, PA 19087 (talbot@aya.yale.edu)
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Abstract

Development of antibiotics to treat infections caused by multidrug-resistant gram-negative bacilli has lagged significantly behind development of antibiotics to treat infections with gram-positive pathogens. Although a few promising drugs have entered early clinical development, more must be done to preserve the utility of currently available antibiotics and to ensure a pipeline of efficacious, safe antibacterials.

Type
Supplement Article
Information
Infection Control & Hospital Epidemiology , Volume 31 , Issue S1: Papers from the Fifth Decennial International Conference on Healthcare-Associated Infections , November 2010 , pp. S55 - S58
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2010

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References

1.Kallen, AJ, Srinivasan, A. Current epidemiology of multidrug-resistant gram-negative bacilli in the United States. Infect Control Hosp Epidemiol 2010;31(11 Suppl 1):S51–S54 (in this supplement).CrossRefGoogle ScholarPubMed
2.Boucher, HW, Talbot, GH, Bradley, JS, et al.Bad bugs, no drugs: no ESKAPE! An update from the Infectious Diseases Society of America. Clin Infect Dis 2009;48(1):1–12.CrossRefGoogle ScholarPubMed
3.European Centre for Disease Prevention and Control (ECDC); European Medicines Agency (EMEA). The bacterial challenge: time to react. A call to narrow the gap between multidrug-resistant bacteria in the EU and the development of new antibacterial agents. Stockholm: European Centre for Disease Prevention and Control, 2009. http://ecdc.europa.eu/en/publications/Publications/0909_TER_The_Bacterial_Challenge_Time_to_React.pdf. Accessed March 19, 2010.Google Scholar
4.Talbot, GH. What's in the pipeline for gram-negative pathogens? Expert Rev Anti Infect Ther 2008;6(1):39–49.CrossRefGoogle Scholar
5. Achaogen. http://www.achaogen.com/. Accessed April 18, 2010.Google Scholar
6. Novexel. Mature and diverse pipeline, http://www.novexel.com/contenu.php?page = pipeline. Accessed April 18, 2010.Google Scholar
7.Ge, Y, Biek, D, Talbot, GH, Sahm, DF. In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. Antimcrob Agents Chemother 2008;52(9):3398–3407.CrossRefGoogle ScholarPubMed
8.Brown, NP, Pillar, CM, Sahm, DF, Ge, Y. Activity profile of CXA-101 and CXA-101/tazobactam against target gram-positive and gram-negative pathogens. In: Program and abstracts of the 49th Interscience Conference of Antimicrobial Agents and Chemotherapy; September 12–15, 2009; San Francisco, CA. Abstract F1-1986.Google Scholar
9. Cubist Pharmaceuticals. Our advancing pipeline, http://www.cubist.com/products/index.php#pipeline. Accessed March 19, 2010.Google Scholar
10. Basilea Pharmaceutica. Anti-infectives research: overview. http://www.basilea.com/Research/Anti-infectives-research/. Accessed April 17, 2010.Google Scholar
11.Infectious Diseases Society of America. The 10 × ‘20 initiative: pursuing a global commitment to develop 10 new antibacterial drugs by 2020. Clin Infect Dis 2010;50(8):1081–1083.CrossRefGoogle Scholar