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Assessment of the Activity of a Novel Light-Activated Antimicrobial Coating in a Clinical Environment

Published online by Cambridge University Press:  02 January 2015

Valérie Decraene ,
Jonathan Pratten  and
Michael Wilson
Valérie Decraene
Affiliation:
Division of Microbial Diseases, Eastman Dental Institute, University College London, London, United Kingdom
Jonathan Pratten
Affiliation:
Division of Microbial Diseases, Eastman Dental Institute, University College London, London, United Kingdom
Michael Wilson*
Affiliation:
Division of Microbial Diseases, Eastman Dental Institute, University College London, London, United Kingdom
*
Division of Microbial Diseases, Eastman Dental Institute, University College London, 256 Grays Inn Rd., London WC1X 8LD, United Kingdom (m.wilson@eastman.ucl.ac.uk)
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Abstract

Cellulose acetate coatings containing the light-activated antimicrobial agents toluidine blue O and rose bengal have previously been shown to be successful in killing a range of microorganisms. Here, we report on the ability of these coatings to achieve reductions in the microbial load on surfaces in a clinical environment.

Type
Concise Communications
Information
Infection Control & Hospital Epidemiology , Volume 29 , Issue 12 , December 2008 , pp. 1181 - 1184
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2008

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References

1. Sexton, T, Clarke, P, O'Neill, E, Dillane, T, Humphreys, H. Environmental reservoirs of methicillin-resistant Staphylococcus aureus in isolation rooms: correlation with patient isolates and implications for hospital hygiene. J Hosp Infect 2006;62:187–194.Google ScholarPubMed
2. Noskin, GA, Bednarz, P, Suriano, T, Reiner, S, Peterson, LR. Persistent contamination of fabric-covered furniture by vancomycin-resistant enterococci: implications for upholstery selection in hospitals. Am J Infect Control 2000;28:311–313.Google ScholarPubMed
3. Panagea, S, Winstanley, C, Walshaw, MJ, Ledson, MJ, Hart, CA. Environmental contamination with an epidemic strain of Pseudomonas aeruginosa in a Liverpool cystic fibrosis centre, and study of its survival on dry surfaces. J Hosp Infect 2005;59:102–107.Google Scholar
4. Decraene, V, Pratten, J, Wilson, M. Cellulose acetate containing toluidine blue and rose bengal is an effective antimicrobial coating when exposed to white light. Appl Environ Microbiol 2006;72:4436–4439.Google ScholarPubMed
5. Lane, DJ, Pace, B, Olsen, GJ, Stahl, DA, Sogin, ML, Pace, NR. Rapid determination of 16S ribosomal RNA sequences for phylogenetic analyses. Proc Natl Acad Sci USA 1985;82:6955–6959.Google ScholarPubMed
6. National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health. Basic Local Alignment Search Tool (BLAST) database. Available at: http://www.ncbi.nlm.nih.gov/BLAST.cgi. Accessed 15 October 2008.Google Scholar
7. Center for Microbial Ecology. Michigan State University. Ribosomal Database Project. Available at: http://rdp.cme.msu.edu/seqmatch/seqmatch_intro.jsp. Accessed 15 October 2008.Google Scholar
8. Wilson, M, Pratten, J. Lethal photosensitization of Staphylococcus aureus in vitro: effect of growth phase, serum and pre-irradiation time. Lasers Surg Med 1995;16:272–276.CrossRefGoogle ScholarPubMed
9. Komerik, N, Nakanishi, H, MacRobert, AJ, Henderson, B, Speight, P, Wilson, M. In vivo killing of Porphyromonas gingivalis by toluidine blue-mediated photosensitization in an animal model. Antimicrob Agents Chemother 2003;47:932–940.CrossRefGoogle ScholarPubMed
10. Wachter, E, Dees, C, Harkins, J, et al. Topical rose bengal: pre-clinical evaluation of pharmacokinetics and safety. Lasers Surg Med 2003;32:101–110.CrossRefGoogle ScholarPubMed
11. Chartered Institute of Building Service Engineers (CIBSE). CIBSE lighting guide LG2: hospitals and healthcare buildings. London: CIBSE; 1989.Google Scholar