Hostname: page-component-cd9895bd7-dzt6s Total loading time: 0 Render date: 2024-12-28T03:55:45.025Z Has data issue: false hasContentIssue false

Azithromycin Prophylaxis During a Hospitalwide Outbreak of a Pertussis-Like Illness

Published online by Cambridge University Press:  02 January 2015

Shay M. Martinez
Affiliation:
Division of Infectious Diseases, Department of Medicine, Santa Clara Valley Medical Center, San Jose California Collaborative Treatment Group, San Diego, California
Carol A. Kemper*
Affiliation:
Division of Infectious Diseases, Department of Medicine, Santa Clara Valley Medical Center, San Jose Division of Infectious Diseases, Department of Medicine, Stanford University, Stanford California Collaborative Treatment Group, San Diego, California
Donna Haiduven
Affiliation:
Infection Control Department, Santa Clara Valley Medical Center, San Jose
Sara H. Cody
Affiliation:
Santa Clara County Public Health Department, San Jose
Stanley C. Deresinski
Affiliation:
Division of Infectious Diseases, Department of Medicine, Santa Clara Valley Medical Center, San Jose Division of Infectious Diseases, Department of Medicine, Stanford University, Stanford
*
Division of Infectious Diseases, Santa Clara Valley Medical Center, 751 S Bascom Ave, San Jose, CA 95128

Abstract

A questionnaire regarding tolerability and adherence was administered for 5 days to hospital employees who received azithromycin prophylaxis during a hospitalwide outbreak of a pertussis-like illness. Analysis of the 239 responses from those having received prophylactic azithromycin determined that it was well tolerated and accounted for a minimal loss of days worked; 81.5% were fully adherent with the regimen.

Type
Concise Communications
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2001

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1. Centers for Disease Control and Prevention. Pertussis outbreak-Vermont, 1998. MMWR 1997;46:822826.Google Scholar
2. Aoyama, T, Sunakawa, K, Iwata, S, Takeuchi, Y, Fujii, R. Efficacy of short-term treatment of pertussis with clarithromycin and azithromycin. J Pediatr 1996;129:761764.CrossRefGoogle ScholarPubMed
3. Roord, JJ, Wolf, BHM, Goossens, MMHT, Kimpen, JLL. Prospective open randomized study comparing efficacies and safeties of a 3-day course of azithromycin and a 10-day course of erythromycin in children with community-acquired acute lower respiratory tract infections. Antimicrob Agents Chemother 1996;40:27652768.CrossRefGoogle Scholar
4. Hoppe, JE, Eichhorn, A. Activity of new macrolides against Bordetella pertussis and Bordetella parapertussis . Eur J Clin Microbiol Infect Dis 1989;8:653654.CrossRefGoogle ScholarPubMed
5. Gray, GC, McPhate, DC, Leinonen, M, Cassell, MH, Deperalta, EP, Putnam, SD, et al. Weekly oral azithromycin as prophylaxis for agents causing acute respiratory disease. Clin Infect Dis 1998;26:103110.CrossRefGoogle ScholarPubMed
6. Haiduven, D, Hench, C, Simpkins, S, Stevens, D. Standardized management of patients and employees exposed to pertussis. Infect Control Hosp Epidemiol 1998;11:861864.CrossRefGoogle Scholar
7. Daniel, R. Simplified treatment of acute lower respiratory tract infection with azithromycin: a comparison with erythromycin and amoxycillin. European Azithromycin Study Group. J Int Med Res 1991;19:373383.CrossRefGoogle ScholarPubMed
8. Schonwald, S, Gunjaca, M, Kolacny-Babic, L, Car, V, Gosev, M. Comparison of azithromycin and erythromycin in the treatment of atypical pneumo-nias. J Antimicrob Chemother 1990;25(suppl A):123126.CrossRefGoogle Scholar
9. Himelright, IM, McAfee, T, Hall, S. Healthcare worker failure to tolerate pertussis postexposure prophylaxis. In: Programs and Abstracts of the Seventh Infectious Diseases Society of America [on CD-ROM]; Philadelphia, PA: November 1999; Abstract 576.Google Scholar