Hostname: page-component-78c5997874-dh8gc Total loading time: 0 Render date: 2024-11-15T04:47:18.491Z Has data issue: false hasContentIssue false
  • English
  • Français

Biofilm Formation by and Accessory Gene Regulator Typing of Methicillin-Resistant Staphylococcus aureus Strains Recovered From Patients With Nosocomial Infections

Published online by Cambridge University Press:  21 June 2016

Kunihiro Manago ,
Junichiro Nishi ,
Naoko Wakimoto ,
Hiroaki Miyanohara ,
Jav Sarantuya ,
Koichi Tokuda ,
Mayumi Iwashita ,
Kimie Yamamoto ,
Masao Yoshinaga  and
Ikuro Maruyama
...Show all authors
Kunihiro Manago
Affiliation:
Department of Pediatrics, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
Junichiro Nishi*
Affiliation:
Department of Pediatrics, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
Naoko Wakimoto
Affiliation:
Department of Pediatrics, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
Hiroaki Miyanohara
Affiliation:
Clinical Laboratory of Kagoshima University Hospital, Kagoshima, Japan
Jav Sarantuya
Affiliation:
Department of Pediatrics, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
Koichi Tokuda
Affiliation:
Department of Pediatrics, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
Mayumi Iwashita
Affiliation:
Department of Pediatrics, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
Kimie Yamamoto
Affiliation:
Department of Pediatrics, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
Masao Yoshinaga
Affiliation:
Department of Pediatrics, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
Ikuro Maruyama
Affiliation:
Department of Laboratory and Molecular Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
Yoshifumi Kawano
Affiliation:
Department of Pediatrics, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
*
Dept. of Pediatrics, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan (nishil@m2.kufm.kagoshima-u.ac.jp)
Get access Rights & Permissions [Opens in a new window]

Abstract

The association between biofilm formation and the accessory gene regulator (agr) types of methicillin-resistant Staphylococcus aureus (MRSA) strains in our hospital were investigated. The biofilm index and the incidence of MRSA strains carrying agr-2 in the infection group (n = 91) were significantly higher than were those in the carrier group (n = 225), suggesting that biofilm formation and agr type are associated with nosocomial MRSA infections.

Type
Concise Communications
Information
Infection Control & Hospital Epidemiology , Volume 27 , Issue 2 , February 2006 , pp. 188 - 190
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2006

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1.Reid, G. Biofilms in infectious disease and on medical devices. Int J Antimicrob Agents 1999; 11:223–226; discussion 237-239.Google Scholar
2.Arciola, CR, Montanaro, L, Baldassarri, L, Borsetti, E, Cavedagna, D, Donati, E. Slime production by staphylococci isolated from prosthesis-associated infections. New Microbiol 1999;22:337–341.Google Scholar
3.Nishi, J, Yoshinaga, M, Miyanohara, H, et al. An epidemiologic survey of methicillin-resistant Staphylococcus aureus by combined use of mec-HVR genotyping and toxin genotyping in a university hospital in Japan. Infect Control Hosp Epidemiol 2002; 23:506–510.Google Scholar
4.Vuong, C, Saenz, HL, Gotz, F, Otto, M. Impact of the agr quorum-sensing system on adherence to polystyrene in Staphylococcus aureus. J Infect Dis 2000; 182:1688–1693.Google Scholar
5.Jarraud, S, Lyon, GJ, Figueiredo, AM, et al. Exfoliatin-producing strains define a fourth agr specificity group in Staphylococcus aureus. J Bacteriol 2000; 182:6517–6522.Google Scholar
6.Goerke, C, Kummel, M, Dietz, K, Wolz, C. Evaluation of intraspecies interference due to agr polymorphism in Staphylococcus aureus during infection and colonization. J Infect Dis 2003; 188:250–256.Google Scholar
7.Garner, JS, Jarvis, WR, Emori, TG, Horan, TC, Hughes, JM. CDC definitions for nosocomial infections, 1988. Am J Infect Control 1988; 16:128–140.Google Scholar
8.Christensen, GD, Simpson, WA, Younger, JJ, et al. Adherence of coagulase-negative staphylococci to plastic tissue culture plates: a quantitative model for the adherence of staphylococci to medical devices. J Clin Microbiol 1985; 22:996–1006.Google Scholar
9.Lina, G, Boutite, F, Tristan, A, Bes, M, Etienne, J, Vandenesch, F. Bacterial competition for human nasal cavity colonization: role of staphylococcal agr alleles. Appl Environ Microbiol 2003; 69:18–23.Google Scholar
10.Knobloch, JK, Horstkotte, MA, Rohde, H, Mack, D. Evaluation of different detection methods of biofilm formation in Staphylococcus aureus. Med Microbiol Immunol (Berl) 2002; 191:101–106.Google Scholar