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Blood Culture Contamination Rates after Skin Antisepsis with Chlorhexidine Gluconate versus Povidone-Iodine in a Pediatric Emergency Department

Published online by Cambridge University Press:  02 January 2015

Lauren Marlowe ,
Rakesh D. Mistry ,
Susan Coffin ,
Kateri H. Leckerman ,
Karin L. McGowan ,
Dingwei Dai ,
Louis M. Bell  and
Theoklis Zaoutis
Lauren Marlowe
Affiliation:
Divisions of General Pediatrics, Philadelphia, Pennsylvania University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
Rakesh D. Mistry
Affiliation:
Emergency Medicine, Philadelphia, Pennsylvania Children's Hospital of Philadelphia, and the Department of Pediatrics, Philadelphia, Pennsylvania
Susan Coffin
Affiliation:
Infectious Diseases, Philadelphia, Pennsylvania Center for Pediatric Clinical Effectiveness, Philadelphia, Pennsylvania Children's Hospital of Philadelphia, and the Department of Pediatrics, Philadelphia, Pennsylvania Center for Clinical Epidemiology and Biostatistics, Philadelphia, Pennsylvania
Kateri H. Leckerman
Affiliation:
Infectious Diseases, Philadelphia, Pennsylvania Department of Pathology and Laboratory Medicine, Philadelphia, Pennsylvania
Karin L. McGowan
Affiliation:
Department of Pathology and Laboratory Medicine, Philadelphia, Pennsylvania
Dingwei Dai
Affiliation:
Center for Pediatric Clinical Effectiveness, Philadelphia, Pennsylvania
Louis M. Bell
Affiliation:
Divisions of General Pediatrics, Philadelphia, Pennsylvania Infectious Diseases, Philadelphia, Pennsylvania Children's Hospital of Philadelphia, and the Department of Pediatrics, Philadelphia, Pennsylvania
Theoklis Zaoutis*
Affiliation:
Infectious Diseases, Philadelphia, Pennsylvania Center for Pediatric Clinical Effectiveness, Philadelphia, Pennsylvania Children's Hospital of Philadelphia, and the Department of Pediatrics, Philadelphia, Pennsylvania Center for Clinical Epidemiology and Biostatistics, Philadelphia, Pennsylvania
*
Children's Hospital of Philadelphia, 34th and Civic Center Boulevard, CHOP North, Room 1527, Philadelphia, PA 19104, (zaoutis@email.chop.edu)
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Extract

Objective.

To determine blood culture contamination rates after skin antisepsis with Chlorhexidine, compared with povidone-iodine.

Design.

Retrospective, quasi-experimental study.

Setting.

Emergency department of a tertiary care children's hospital.

Patients.

Children aged 2-36 months with peripheral blood culture results from February 2004 to June 2008. Control patients were children younger than 2 months with peripheral blood culture results.

Methods.

Blood culture contamination rates were compared using segmented regression analysis of time-series data among 3 patient groups: (1) patients aged 2-36 months during the 26-month preintervention period, in which 10% povidone-iodine was used for skin antisepsis before blood culture; (2) patients aged 2-36 months during the 26-month postintervention period, in which 3% Chlorhexidine gluconate was used; and (3) patients younger than 2 months not exposed to the Chlorhexidine intervention (ie, the control group).

Results.

Results from 11,595 eligible blood cultures were reviewed (4,942 from the preintervention group, 4,274 from the postintervention group, and 2,379 from the control group). For children aged 2-36 months, the blood culture contamination rate decreased from 24.81 to 17.19 contaminated cultures per 1,000 cultures (P < .05) after implementation of Chlorhexidine. This decrease of 7.62 contaminated cultures per 1,000 cultures (95% confidence interval, —0.781 to —15.16) represented a 30% relative decrease from the preintervention period and was sustained over the entire postintervention period. No change in contamination rate was observed in the control group (P = .337).

Conclusion.

Skin antisepsis with Chlorhexidine significantly reduces the blood culture contamination rate among young children, as compared with povidone-iodine.

Type
Original Article
Information
Infection Control & Hospital Epidemiology , Volume 31 , Issue 2 , February 2010 , pp. 171 - 176
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2010

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