Hostname: page-component-cd9895bd7-mkpzs Total loading time: 0 Render date: 2024-12-28T19:35:22.607Z Has data issue: false hasContentIssue false
  • English
  • Français

Can Matrix-Assisted Laser Desorption Ionization Time-of-Flight Mass Spectrometry (MALDI-TOF) Enhance Antimicrobial Stewardship Efforts in the Acute Care Setting?

Published online by Cambridge University Press:  02 January 2015

Pranita D. Tamma ,
Kennard Tan ,
Veronique R. Nussenblatt ,
Alison E. Turnbull ,
Karen C. Carroll  and
Sara E. Cosgrove
Pranita D. Tamma*
Affiliation:
Department of Pediatrics, Division of Infectious Diseases, Johns Hopkins Medical Institutions, Baltimore, Maryland
Kennard Tan
Affiliation:
Department of Microbiology, Royal Jubilee Hospital, British Columbia, Canada
Veronique R. Nussenblatt
Affiliation:
Department of Medicine, Division of Infectious Diseases, Johns Hopkins Medical Institutions, Baltimore, Maryland
Alison E. Turnbull
Affiliation:
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland
Karen C. Carroll
Affiliation:
Department of Pathology, Division of Medical Microbiology, Johns Hopkins Medical Institutions, Baltimore, Maryland
Sara E. Cosgrove
Affiliation:
Department of Medicine, Division of Infectious Diseases, Johns Hopkins Medical Institutions, Baltimore, Maryland
*
Department of Pediatrics, Division of Infectious Diseases, Johns Hopkins Medical Institutions, 200 North Wolfe Street, Suite 3155, Baltimore, MD 21287 (ptamma1@jhmi.edu)
Get access Rights & Permissions [Opens in a new window]

Abstract

We evaluated 222 hospitalized patients whose clinical isolates were tested using standard methods and matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF). MALDI-TOF could have reduced time to appropriate therapy for 28.8% and 44.6% patients based on the treating physician's choices and stewardship team recommendations, respectively. Clinicians should be aware of scenarios in which MALDI-TOF can optimize antibiotic therapy.

Type
Concise Communication
Information
Infection Control & Hospital Epidemiology , Volume 34 , Issue 9 , September 2013 , pp. 990 - 995
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2013

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1.Tan, KE, Ellis, BC, Lee, R, Stamper, PD, Zhang, SX, Carroll, KC. Prospective evaluation of a matrix-assisted laser desorption ion-ization-time of flight mass spectrometry system in a hospital clinical microbiology laboratory for identification of bacteria and yeasts: a bench-by-bench study for assessing the impact on time to identification and cost-effectiveness. J Clin Microbiol 2012;50: 3301–3308.CrossRefGoogle Scholar
2.Wieser, A, Schneider, L, Jung, J, Schubert, S. MALDI-TOF MS in microbiological diagnostics-identification of microorganisms and beyond (mini review). Appi Microbiol Biotechnol 2012;93:965–974.CrossRefGoogle ScholarPubMed
3.Garnacho-Montero, J, Ortiz-Leyba, C, Herrera-Melero, I, et al.Mortality and morbidity attributable to inadequate empirical antimicrobial therapy in patients admitted to the ICU with sepsis: a matched cohort study. J Antimicrob Chemother 2008;61:436–441.CrossRefGoogle Scholar
4.Kang, CI, Kim, SH, Park, WB, et al.Bloodstream infections caused by antibiotic-resistant gram-negative bacilli: risk factors for mortality and impact of inappropriate initial antimicrobial therapy on outcome. Antimicrob Agents Chemother 2005;49:760–766.CrossRefGoogle Scholar
5.Clerc, O, Prod'hom, G, Vogne, C, Bizzini, A, Calandra, T, Greub, G. Impact of matrix-assisted laser desorption ionization time-offlight mass spectrometry (MALDI-TOF) on the clinical management of patients with gram-negative bacteremia: a prospective observational study. Clin Infect Dis 2013;56:1101–1107.CrossRefGoogle Scholar
6.Vlek, AL, Bonten, MJ, Boel, CH. Direct matrix-assisted laser desorption ionization time-of-flight mass spectrometry improves appropriateness of antibiotic treatment of bacteremia. PLoS One 2012;7:e32589.CrossRefGoogle ScholarPubMed
7.Hodiamont, CJ, Gouliouris, T, Rozemeijer, W, Veldkamp, KE, Wever, P, Visser, C. Direct identification of micro-organisms in positive blood cultures using MALDI-TOF MS: consequences for advice on antibiotic therapy. Poster presented at: European Congress of Clinical Microbiology and Infectious Diseases 2012; April 3,2012; London; Poster 2322.Google Scholar
8.Tamma, PD, Cosgrove, SE. Antimicrobial stewardship. Infect Dis Clin North Am 2011;25:245–260.CrossRefGoogle ScholarPubMed