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Equal Efficacy of Glucoprotamin and an Aldehyde Product for Environmental Disinfection in a Hematologic Transplant Unit: A Prospective Crossover Trial

Published online by Cambridge University Press:  02 January 2015

Ruth Meinke ,
Bernhard Meyer ,
Reno Frei ,
Jakob Passweg  and
Andreas F. Widmer
Ruth Meinke
Affiliation:
University Hospital Basel, Basel, Switzerland
Bernhard Meyer
Affiliation:
Ecolab Deutschland, RD&E Healthcare EMEA, Düsseldorf, Germany
Reno Frei
Affiliation:
University Hospital Basel, Basel, Switzerland
Jakob Passweg
Affiliation:
University Hospital Basel, Basel, Switzerland
Andreas F. Widmer*
Affiliation:
University Hospital Basel, Basel, Switzerland
*
Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland (awidmer@uhbs.ch)
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Abstract

Background.

The inanimate hospital environment has emerged as an important reservoir of nosocomial pathogens. In particular, multidrug-resistant pathogens, such as methicillin-resistant Staphylococcus aureus, Acinetobacter species, and Clostridium difficile, play a major role in the transmission of hospital-acquired infections. In Europe, aldehydes, chlorine, and quaternary ammonium compounds have been commonly used for environmental disinfection. Glucoprotamin, a newer active compound for disinfectants, has been clinically tested for disinfection of instruments but not for environmental disinfection.

Objective.

This study evaluated the antimicrobial effectiveness of a glucoprotamin-containing product (Incidin) compared with that of an aldehyde-containing product (Deconex), the current standard at our institution.

Methods.

This prospective crossover study was conducted in our access-restricted hematologic transplant unit. A total of 3,086 samples from the environment were processed and examined for overall bacterial burden as well as selectively for S. aureus, C. difficile, and gram-negative bacteria.

Results.

There was no significant difference in residual bacteria after disinfection between the 2 products in terms of overall burden and selected pathogens. Enterococci were the predominant pathogens recovered from surfaces, but no vancomycin-resistant enterococci were recovered. Similarly, C. difficile could not be found in the patients' environment, even in rooms, despite the use of selective media.

Conclusion.

The aldehyde-containing product (Deconex) and the glucoprotamin-containing product (Incidin) demonstrated similar efficacy against environmental contamination in a hematologic transplant unit with the application of selective media for C. difficile, S. aureus, and gram-negative bacteria in addition to standard medium.

Type
Original Articles
Information
Infection Control & Hospital Epidemiology , Volume 33 , Issue 11 , November 2012 , pp. 1077 - 1080
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2012

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