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Identification of a norovirus outbreak on a hematopoietic stem cell transplant unit and development and implementation of a novel infection prevention algorithm for controlling transmission

Published online by Cambridge University Press:  24 February 2020

Westyn Branch-Elliman Open the ORCID record for Westyn Branch-Elliman [Opens in a new window] ,
Roger V. Araujo-Castillo ,
Graham M. Snyder ,
Bernadette F. Sullivan ,
Carolyn D. Alonso  and
Sharon B. Wright
Westyn Branch-Elliman*
Affiliation:
Section of Infectious Diseases, Department of Medicine, Veterans’ Affairs (VA) Boston Healthcare System, West Roxbury, Massachusetts, United States VA Boston Center for Healthcare Organization and Implementation Research, Boston, Massachusetts, United States Harvard Medical School, Boston, Massachusetts, United States
Roger V. Araujo-Castillo
Affiliation:
Facultad de Ciencias de la Salud, Universidad Peruana de Ciencias Aplicadas, Lima, Peru
Graham M. Snyder
Affiliation:
Department of Infection Prevention and Control, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States
Bernadette F. Sullivan
Affiliation:
Division of Infection Control/Hospital Epidemiology, Silverman Institute for Health Care Quality and Safety, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States
Carolyn D. Alonso
Affiliation:
Harvard Medical School, Boston, Massachusetts, United States Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States
Sharon B. Wright
Affiliation:
Harvard Medical School, Boston, Massachusetts, United States Division of Infection Control/Hospital Epidemiology, Silverman Institute for Health Care Quality and Safety, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States
*
Author for correspondence: Westyn Branch-Elliman MD, MMSc, Email: wbranche@bidmc.harvard.edu
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Abstract

Controlling norovirus transmission in units with immunocompromised patients is challenging. We present a cluster of norovirus cases that occurred on a stem-cell transplant unit and the prevention efforts that were implemented to limit the outbreak. Protocols developed to control this cluster may provide a model for other facilities.

Type
Concise Communication
Information
Infection Control & Hospital Epidemiology , Volume 41 , Issue 4 , April 2020 , pp. 472 - 476
Copyright
© 2020 by The Society for Healthcare Epidemiology of America. All rights reserved

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References

Bok, K, Green, KY. Norovirus gastroenteritis in immunocompromised patients. N Engl J Med 2012;367:2126–2132.CrossRefGoogle ScholarPubMed
Green, KY. Norovirus infection in immunocompromised hosts. Clin Microbiol Infect 2014;20:717–723.CrossRefGoogle ScholarPubMed
Schwartz, S, Vergoulidou, M, Schreier, E, et al.Norovirus gastroenteritis causes severe and lethal complications after chemotherapy and hematopoietic stem cell transplantation. Blood 2011;117:5850–5856.CrossRefGoogle ScholarPubMed
Avery, RK, Lonze, BE, Kraus, ES, Marr, KA, Montgomery, RA. Severe chronic norovirus diarrheal disease in transplant recipients: clinical features of an under-recognized syndrome. Transpl Infect Dis 2017;19.Google ScholarPubMed
van Beek, J, van der Eijk, AA, Fraaij, PL, et al.Chronic norovirus infection among solid organ recipients in a tertiary care hospital, the Netherlands, 2006–2014. Clin Microbiol Infect 2017;23:265.CrossRefGoogle Scholar
Barclay, L, Park, GW, Vega, E, et al.Infection control for norovirus. Clin Microbiol Infect 2014;20:731–740.CrossRefGoogle ScholarPubMed
Center for Disease Control and Prevention Division of Viral Diseases, Respiratory Diseases. Updated norovirus outbreak management and disease prevention guidelines. MMWR Recomm Rep 2011;60:1–18.Google Scholar
Doshi, M, Woodwell, S, Kelleher, K, Mangan, K, Axelrod, P. An outbreak of norovirus infection in a bone marrow transplant unit. Am J Infect Control 2013;41:820–823.CrossRefGoogle Scholar
Robles, JD, Cheuk, DK, Ha, SY, Chiang, AK, Chan, GC. Norovirus infection in pediatric hematopoietic stem cell transplantation recipients: incidence, risk factors, and outcome. Biol Blood Marrow Transpl 2012;18:1883–1889.CrossRefGoogle ScholarPubMed
Branch-Elliman, W, Snyder, GM, King, AD, et al.Correlation of hand hygiene compliance measured by direct observation with estimates obtained from product usage. Infect Control Hosp Epidemiol 2018;39:746–749.CrossRefGoogle ScholarPubMed
Greig, JD, Lee, MB. A review of nosocomial norovirus outbreaks: infection control interventions found effective. Epidemiol Infect 2012;140:1151–1160.CrossRefGoogle ScholarPubMed
Harris, JP, Lopman, BA, Cooper, BS, O’Brien, SJ. Does spatial proximity drive norovirus transmission during outbreaks in hospitals? BMJ Open 2013;3(7). pii: e003060. doi: 10.1136/bmjopen-2013-003060.CrossRefGoogle ScholarPubMed
Nenonen, NP, Hannoun, C, Svensson, L, et al.Norovirus GII.4 detection in environmental samples from patient rooms during nosocomial outbreaks. J Clin Microbiol 2014;52:2352–2358.CrossRefGoogle ScholarPubMed
Alsved, M, Fraenkel, C-J, Bohgard, M, et al.Sources of airborne norovirus in hospital outbreaks. Clin Infect Dis 2019. pii: ciz584. doi: 10.1093/cid/ciz584.Google Scholar
Lee, BY, Wettstein, ZS, McGlone, SM, et al.Economic value of norovirus outbreak control measures in healthcare settings. Clin Microbiol Infect 2011;17:640–646.CrossRefGoogle ScholarPubMed
Roddie, C, Paul, JP, Benjamin, R, et al.Allogeneic hematopoietic stem cell transplantation and norovirus gastroenteritis: a previously unrecognized cause of morbidity. Clin Infect Dis 2009;49:1061–1068.CrossRefGoogle ScholarPubMed
Koo, HL, Ajami, NJ, Jiang, ZD, et al.A nosocomial outbreak of norovirus infection masquerading as Clostridium difficile infection. Clin Infect Dis 2009;48:e75–e77.CrossRefGoogle ScholarPubMed
MacAllister, TJ, Stednick, Z, Golob, JL, Huang, ML, Pergam, SA. Underutilization of norovirus testing in hematopoietic cell transplant recipients at a large cancer center. Am J Infect Control 2018;46:100–102.CrossRefGoogle Scholar
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