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Immunotherapies for Staphylococcus aureus: Current Challenges and Future Prospects

Published online by Cambridge University Press:  02 January 2015

Stan Deresinski  and
Victor Herrera
Stan Deresinski*
Affiliation:
Department of Medicine, Division of Infectious Diseases and Geographic Medicine, Stanford University, Stanford, California
Victor Herrera
Affiliation:
Department of Medicine, Division of Infectious Diseases and Geographic Medicine, Stanford University, Stanford, California
*
300 Pasteur Drive, Grant Building, Room S-101D, Stanford, CA 94305-5107 (polishmd@stanford.edu)
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Abstract

Development of an effective vaccine against Staphylococcus aureus would provide great potential public health benefit. We present a brief overview of the current knowledge in this field, with emphasis on present challenges and lessons learned, together with a summary of vaccines and immunoglobulin preparations currently under investigation.

Type
Supplement Article
Information
Infection Control & Hospital Epidemiology , Volume 31 , Issue S1: Papers from the Fifth Decennial International Conference on Healthcare-Associated Infections , November 2010 , pp. S45 - S47
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2010

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References

1.Zetola, N, Francis, J, Nuermberger, E, Bishai, W. Community-acquired methicillin-resistant Staphylococcus aureus: an emerging threat. Lancet Infect Dis 2005;5(5):275–286.CrossRefGoogle ScholarPubMed
2.Lucero, CA, Hageman, J, Zell, ER, et al.Evaluating the potential public health impact of a Staphylococcus aureus vaccine through use of population-based surveillance for invasive methicillin-resistant S. aureus disease in the United States. Vaccine 2009;27(37):5061–5068.CrossRefGoogle ScholarPubMed
3. Nabi Biopharmaceuticals. Nabi Biopharmaceuticals announces results of StaphVAX® confirmatory phase III clinical trial. News release. November 1, 2005. http://www.nabi.com/. Accessed April 12, 2010.Google Scholar
4.Shinefield, H, Black, S, Fattom, A, et al.Use of a Staphylococcus aureus conjugate vaccine in patients receiving hemodialysis. N Engl J Med 2002;346(7):491–496.CrossRefGoogle ScholarPubMed
5.Becher, D, Hempel, K, Sievers, S, et al.A proteomic view of an important human pathogen—towards the quantification of the entire Staphylococcus aureus proteome. PLoS One 2009;4(12):e8176.Google Scholar
6.Ziebandt, AK, Kusch, H, Degner, M, et al.Proteomics uncovers extreme heterogeneity in the Staphylococcus aureus exoproteome due to genomic plasticity and variant gene regulation. Proteomics 2010;10(8):1634–1644.Google Scholar
7.Yoong, P, Pier, G. Antibody-mediated enhancement of community-acquired methicillin-resistant Staphylococcus aureus infection. Proc Natl Acad Sci USA 2010;107(5):2241–2246.Google Scholar
8.ClinicalTrials.gov. An evaluation of three dose levels of 3-antigen Staphylococcus aureus vaccine (SA3Ag) in healthy adults. Sponsor: Wyeth. ClinicalTrials.gov identifier NCT01018641. http://www.clinicaltrials.gov/. Accessed April 12, 2010.Google Scholar
9.Kim, HK, Dedent, A, Cheng, AG, et al.IsdA and IsdB antibodies protect mice against Staphylococcus aureus abscess formation and lethal challenge. Vaccine 2010;28(38):6382–6392.CrossRefGoogle ScholarPubMed
10.Stranger-Jones, Y, Bae, T, Schneewind, O. Vaccine assembly from surface proteins of Staphylococcus aureus. Proc Natl Acad Sci USA 2006;103(45):16942–16947.Google Scholar