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Methods of estimating vancomycin use in an inpatient setting: days of therapy versus therapeutic drug monitoring–based exposure days

Published online by Cambridge University Press:  07 February 2019

Shutaro Murakami Open the ORCID record for Shutaro Murakami [Opens in a new window] ,
Junko Hiroi ,
Yasuharu Tokuda ,
Ed Casabar  and
Hitoshi Honda
Shutaro Murakami*
Affiliation:
Department of Pharmacy, Tokyo Metropolitan Tama Medical Center, Tokyo, Japan Department of Infection Control, Tokyo Metropolitan Tama Medical Center, Tokyo, Japan
Junko Hiroi
Affiliation:
Department of Pharmacy, Tokyo Metropolitan Tama Medical Center, Tokyo, Japan
Yasuharu Tokuda
Affiliation:
Muribushi Project for Teaching Hospitals, Okinawa, Japan
Ed Casabar
Affiliation:
Department of Pharmacy, Barnes-Jewish Hospital, Washington University Medical Center St Louis, Missouri
Hitoshi Honda
Affiliation:
Department of Infection Control, Tokyo Metropolitan Tama Medical Center, Tokyo, Japan
*
Author for correspondence: Shutaro Murakami, Email: shuutarou_murakami@tmhp.jp
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Abstract

Underestimating antimicrobial use based on days of therapy (DOT) is recognized for certain antimicrobial agents. We investigated the difference between DOT and therapeutic drug monitoring (TDM)–based exposure days in estimating vancomycin use and demonstrated that DOT may underestimate vancomycin exposure by ∼10%.

Type
Concise Communication
Information
Infection Control & Hospital Epidemiology , Volume 40 , Issue 3 , March 2019 , pp. 375 - 379
Copyright
© 2019 by The Society for Healthcare Epidemiology of America. All rights reserved. 

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References

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