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Regional outbreak of multidrug-resistant Klebsiella pneumoniae carbapenemase–producing Pseudomonas Aeruginosa

Published online by Cambridge University Press:  01 October 2021

Bekana K. Tadese ,
Anna Nutt ,
Ifrah Chaudhary ,
Charlene Offiong  and
Charles Darkoh Open the ORCID record for Charles Darkoh [Opens in a new window]
Bekana K. Tadese
Affiliation:
Fort Bend County Health and Human Services, Texas Department of Epidemiology, Human Genetics, and Environmental Sciences, Center for Infectious Diseases, School of Public Health, University of Texas Health Science Center, Houston, Texas
Anna Nutt
Affiliation:
Texas Department of State Health Services, Texas
Ifrah Chaudhary
Affiliation:
Houston Health Department, Houston, Texas
Charlene Offiong
Affiliation:
Houston Health Department, Houston, Texas
Charles Darkoh*
Affiliation:
Department of Epidemiology, Human Genetics, and Environmental Sciences, Center for Infectious Diseases, School of Public Health, University of Texas Health Science Center, Houston, Texas MD Anderson Cancer Center University of Texas Health Graduate School of Biomedical Sciences, Microbiology, and Infectious Diseases Program, University of Texas Health Science Center, Houston, Texas
*
Author for correspondence: Charles Darkoh, E-mail: Charles.Darkoh@uth.tmc.edu
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Abstract

Klebsiella pneumoniae carbapenemase-producing P. aeruginosa (KPC-CRPA) are rare in the United States. An outbreak of KPC-CRPA was investigated in Texas using molecular and epidemiologic methods and 17 cases of KPC-CRPA were identified. The isolates were genetically related and harbored the emerging P. aeruginosa multilocus sequence type 235, the first in the United States.

Type
Concise Communication
Information
Infection Control & Hospital Epidemiology , Volume 44 , Issue 1 , January 2023 , pp. 96 - 98
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Copyright
© The Author(s), 2021. Published by Cambridge University Press on behalf of The Society for Healthcare Epidemiology of America

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References

Magiorakos, AP, Burns, K, Rodríguez Baño, J, et al. Infection prevention and control measures and tools for the prevention of entry of carbapenem-resistant Enterobacteriaceae into healthcare settings: guidance from the European Centre for Disease Prevention and Control. Antimicrob Resist Infect Control 2017; 6:113.CrossRefGoogle ScholarPubMed
Won, SY, Munoz-Price, LS, Lolans, K, et al. Emergence and rapid regional spread of Klebsiella pneumoniae carbapenemase-producing Enterobacteriaceae. Clin Infect Dis 2011;53:532–540.CrossRefGoogle ScholarPubMed
Endimiani, A, Depasquale, JM, Forero, S, et al. Emergence of blaKPC-containing Klebsiella pneumoniae in a long-term acute-care hospital: a new challenge to our healthcare system. J Antimicrob Chemother 2009;64:1102–1110.CrossRefGoogle Scholar
Chen, WK, Yang, Y, Tan, BH. Increased mortality among carbapenemase-producing carbapenem-resistant Enterobacteriaceae carriers who developed clinical isolates of another genotype. Open Forum Infect Dis 2019;6(2):ofz006.CrossRefGoogle ScholarPubMed
Ben-David, D, Kordevani, R, Keller, N, et al. Outcome of carbapenem resistant Klebsiella pneumoniae bloodstream infections. Clin Microbiol Infect 2012;18:54–60.CrossRefGoogle ScholarPubMed
Villegas, MV, Lolans, K, Correa, A, et al. First identification of Pseudomonas aeruginosa isolates producing a KPC-type carbapenem-hydrolyzing beta-lactamase. Antimicrob Agents Chemother 2007;51:1553–1555.CrossRefGoogle ScholarPubMed
Centers for Disease Prevention and Control. Antibiotic Resistance Threats in the United States, 2013. Atlanta: US Department of Health and Human Services, CDC; 2013.Google Scholar
Walters, MS, Grass, JE, Bulens, SN, et al. Carbapenem-resistant Pseudomonas aeruginosa at US emerging infections program sites, 2015. Emerg Infect Dis 2019;25:1281–1288.CrossRefGoogle ScholarPubMed
Toleman, MA, Rolston, K, Jones, RN, Walsh, TR. blaVIM-7, an evolutionarily distinct metallo-lactamase gene in a Pseudomonas aeruginosa isolate from the United States. Antimicrob Agents Chemother 2004;48:329–332.CrossRefGoogle Scholar
Poirel, L, Nordmann, P, Lagrutta, E, Cleary, T, Munoz-Price, LS. Emergence of KPC-producing Pseudomonas aeruginosa in the United States. Antimicrob Agents Chemother 2010;54:3072.CrossRefGoogle ScholarPubMed