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Risk Factors for Central Venous Catheter–Associated Bloodstream Infection in Pediatric Patients: A Cohort Study

Published online by Cambridge University Press:  03 May 2016

Jillian Hansen Carter ,
Joanne Marie Langley ,
Stefan Kuhle  and
Susan Kirkland
Jillian Hansen Carter
Affiliation:
Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
Joanne Marie Langley*
Affiliation:
Department of Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada Department of Community Health and Epidemiology, Dalhousie University, Halifax, Nova Scotia, Canada Department of Obstetrics and Gynecology, Dalhousie University, Halifax, Nova Scotia, Canada
Stefan Kuhle
Affiliation:
Department of Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada Department of Community Health and Epidemiology, Dalhousie University, Halifax, Nova Scotia, Canada IWK Health Centre, Halifax, Nova Scotia, Canada Department of Obstetrics and Gynecology, Dalhousie University, Halifax, Nova Scotia, Canada
Susan Kirkland
Affiliation:
Department of Community Health and Epidemiology, Dalhousie University, Halifax, Nova Scotia, Canada
*
Address correspondence to Joanne M. Langley MD, MSc, FSHEA, IWK Health Centre, Goldbloom RCC Pavilion, 4th floor, 5850/5980 University Avenue, Halifax, NS, Canada B3K 6R8 (joanne.langley@dal.ca).
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Abstract

OBJECTIVE

To examine the incidence of central-line–associated bloodstream infection (CLABSI) over time and to determine risk factors for CLABSI in hospitalized children.

DESIGN

Prospective cohort study.

SETTING

Pediatric tertiary care referral center in Halifax, Nova Scotia, serving a population of 2.3 million.

PARTICIPANTS

Patients ages 0–18 years with central venous catheters (CVCs) inserted at this facility between 1995 and 2013.

METHODS

Participants were followed from CVC insertion to CLABSI event or until CVC removal. Data were prospectively collected by clinicians, infection prevention and control staff, and nursing staff for the purposes of patient care, surveillance, and quality improvement. Cox proportional hazards regression was used to identify risk factors for CLABSI.

RESULTS

Among 5,648 patients, 385 developed CLABSI (0.74 CLABSI per 1,000 line days; or 3.87 per 1,000 in-hospital line days). Most infections occurred within 60 days of insertion. CLABSI rates decreased from 4.87 per 1,000 in-hospital line days in 1995 to 0.78 per 1,000 in-hospital line days in 2013, corresponding to an 84% reduction. A temporal association of CLABSI reduction with a hand hygiene promotion campaign was identified. CVC type, number of lumens, dressing type, insertion vein, and being in the critical care unit were statistically significantly associated with CLABSI.

CONCLUSIONS

Hospital-wide surveillance over an 18-year period identified children at highest risk for CLABSI and decreasing risk over time; this decrease was temporally associated with a hand hygiene campaign.

Infect Control Hosp Epidemiol 2016;37:939–945

Type
Original Articles
Information
Infection Control & Hospital Epidemiology , Volume 37 , Issue 8 , August 2016 , pp. 939 - 945
Copyright
© 2016 by The Society for Healthcare Epidemiology of America. All rights reserved 

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References

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