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Risk factors for the development of infections associated with carbapenemase-producing Enterobacteriaceae among previously colonized patients: A retrospective cohort study

Published online by Cambridge University Press:  20 November 2020

Adriana Jimenez Open the ORCID record for Adriana Jimenez [Opens in a new window] ,
Kristopher Fennie Open the ORCID record for Kristopher Fennie [Opens in a new window] ,
L. Silvia Munoz-Price Open the ORCID record for L. Silvia Munoz-Price [Opens in a new window] ,
Boubakari Ibrahimou Open the ORCID record for Boubakari Ibrahimou [Opens in a new window] ,
Lilian M. Abbo Open the ORCID record for Lilian M. Abbo [Opens in a new window] ,
Octavio Martinez ,
Kathleen Sposato ,
Yohei Doi Open the ORCID record for Yohei Doi [Opens in a new window]  and
Mary Jo Trepka
Adriana Jimenez*
Affiliation:
Department of Infection Prevention and Control, Jackson Health System, Miami, Florida Department of Epidemiology, Robert Stempel College of Public Health and Social Work, Florida International University, Miami, Florida
Kristopher Fennie
Affiliation:
Division of Natural Sciences, New College of Florida, Sarasota, Florida
L. Silvia Munoz-Price
Affiliation:
Department of Medicine, Division of Infectious Diseases, Medical College of Wisconsin Milwaukee, Wisconsin
Boubakari Ibrahimou
Affiliation:
Department of Biostatistics, Robert Stempel College of Public Health and Social Work, Florida International University, Miami, Florida
Lilian M. Abbo
Affiliation:
Department of Infection Prevention and Control, Jackson Health System, Miami, Florida Division of Infectious Diseases, University of Miami Miller School of Medicine, Miami, Florida
Octavio Martinez
Affiliation:
Department of Pathology and Laboratory Medicine, Department of Surgery, University of Miami Miller School of Medicine, Miami, Florida
Kathleen Sposato
Affiliation:
Department of Infection Prevention and Control, Jackson Health System, Miami, Florida
Yohei Doi
Affiliation:
Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
Mary Jo Trepka
Affiliation:
Department of Epidemiology, Robert Stempel College of Public Health and Social Work, Florida International University, Miami, Florida
*
Author for correspondence: Adriana Jimenez, E-mail: adriana.jimenez@jhsmiami.org
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Abstract

Not all patients who acquire carbapenemase-producing Enterobacteriaceae (CPE) develop infections by these organisms; many remain only colonized. Of 54 CPE-colonized patients, 16 (30%) developed CPE infections. We identified indwelling urinary catheter exposure, exposure to intravenous colistin, and overseas transfer as variables associated with CPE infection development among colonized patients.

Type
Concise Communication
Information
Infection Control & Hospital Epidemiology , Volume 42 , Issue 6 , June 2021 , pp. 763 - 766
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Copyright
© The Author(s), 2020. Published by Cambridge University Press on behalf of The Society for Healthcare Epidemiology of America

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References

Division of Healthcare Quality Promotion. Facility guidance for control of carbapenem-resistant Enterobacteriaceae (CRE). November 2015 update—CRE toolkit. Centers for Disease Control and Prevention website. http://www.cdc.gov/hai/pdfs/cre/CRE-guidance-508.pdf. Updated 2015. Accessed April 15, 2016.Google Scholar
Solter, E, Adler, A, Rubinovitch, B, et al. Israeli national policy for carbapenem-resistant enterobacteriaceae screening, carrier isolation and discontinuation of isolation. Infect Control Hosp Epidemiol 2018;39:85–89.CrossRefGoogle ScholarPubMed
Borer, A, Saidel-Odes, L, Eskira, S, et al. Risk factors for developing clinical infection with carbapenem-resistant Klebsiella pneumoniae in hospital patients initially only colonized with carbapenem-resistant K pneumoniae . Am J Infect Control 2012;40:421–425.CrossRefGoogle ScholarPubMed
Tischendorf, J, de Avila, RA, Safdar, N. Risk of infection following colonization with carbapenem-resistant enterobactericeae: a systematic review. Am J Infect Control 2016;44:539–543.CrossRefGoogle ScholarPubMed
2019 NHSN patient safety component manual. Centers for Disease Control and Prevention website. https://www.cdc.gov/nhsn/pdfs/validation/2019/pcsmanual_2019-508.pdf. Published 2019. Accessed October 26, 2020.Google Scholar
McConville, TH, Sullivan, SB, Gomez-Simmonds, A, Whittier, S, Uhlemann, A. Carbapenem-resistant Enterobacteriaceae colonization (CRE) and subsequent risk of infection and 90-day mortality in critically ill patients, an observational study. PloS One 2017;12(10):e0186195.CrossRefGoogle ScholarPubMed
Tsuji, BT, Pogue, JM, Zavascki, AP, et al. International consensus guidelines for the optimal use of the polymyxins: endorsed by the American College of Clinical Pharmacy (ACCP), European Society of Clinical Microbiology and Infectious Diseases (ESCMID), Infectious Diseases Society of America (IDSA), International Society for Anti-infective Pharmacology (ISAP), Society of Critical Care Medicine (SCCM), and Society of Infectious Diseases Pharmacists (SIDP). Pharmacotherapy 2019;39:10–39.CrossRefGoogle Scholar
Chew, KL, La, M, Lin, RT, Teo, JW. Colistin and polymyxin B susceptibility testing for carbapenem-resistant and mcr-positive Enterobacteriaceae: comparison of sensititre, MicroScan, vitek 2, and Etest with broth microdilution. J Clin Microbiol 2017;55:2609–2616.CrossRefGoogle ScholarPubMed
El-Sayed, A, Abd El-Gawad, M, Zhong, L, et al. Colistin and its role in the era of antibiotic resistance: an extended review (2000–2019). Emerg Microb Infect 2020;9:868–885.CrossRefGoogle Scholar
Lo, E, Nicolle, L, Classen, D, et al. Strategies to prevent catheter-associated urinary tract infections in acute care hospitals. Infect Control Hosp Epidemiol 2008;29 suppl 1:S41–S50.CrossRefGoogle Scholar
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