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Time to Detection in Culture Supports Prediction of Low Transmissibility of Tuberculosis and Discontinuation of Isolation for Low-Risk Patients With A Single AFB-Negative and NAAT-Negative Respiratory Specimen

Published online by Cambridge University Press:  19 March 2018

Saahir Khan ,
Audrey Nakasone ,
Minoo Ghajar ,
Mariam Zhowandai ,
Sunita Prabhu ,
Rick Alexander ,
Julie Low ,
Ellena Peterson  and
Lauri Thrupp
Saahir Khan*
Affiliation:
Division of Infectious Diseases, Department of Medicine, University of California Irvine Health, Orange, California
Audrey Nakasone
Affiliation:
Division of Medical Microbiology, Department of Pathology, University of California Irvine Health, Orange, California
Minoo Ghajar
Affiliation:
Public Health Laboratory
Mariam Zhowandai
Affiliation:
Pulmonary Disease Services, Orange County Health Care Agency, Santa Ana, California.
Sunita Prabhu
Affiliation:
Public Health Laboratory
Rick Alexander
Affiliation:
Public Health Laboratory
Julie Low
Affiliation:
Pulmonary Disease Services, Orange County Health Care Agency, Santa Ana, California.
Ellena Peterson
Affiliation:
Division of Medical Microbiology, Department of Pathology, University of California Irvine Health, Orange, California
Lauri Thrupp
Affiliation:
Division of Infectious Diseases, Department of Medicine, University of California Irvine Health, Orange, California Division of Medical Microbiology, Department of Pathology, University of California Irvine Health, Orange, California
*
Address correspondence to Lauri Thrupp, Division of Infectious Diseases, Department of Medicine, University of California Irvine Health, 333 City Blvd West, The City Tower, Suite 400, Orange, CA 92868 (ldthrupp@uci.edu).
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Abstract

For 94 patients with culture-positive pulmonary tuberculosis, time-to-detection (TTD), acid-fast bacilli (AFB) smear, and nucleic acid amplification test (NAAT) results were reviewed. All 12 patients whose first specimen was negative by AFB smear and NAAT had prolonged TTD, indicating low transmissibility and supporting discontinuing isolation for low-risk patients.

Infect Control Hosp Epidemiol 2018;39:619–621

Type
Concise Communications
Information
Infection Control & Hospital Epidemiology , Volume 39 , Issue 5 , May 2018 , pp. 619 - 621
Copyright
© 2018 by The Society for Healthcare Epidemiology of America. All rights reserved 

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Footnotes

PREVIOUS PRESENTATION. Some of these data were presented in brief as a poster at the ID Week conference on October 28, 2016, in New Orleans, Louisiana.

References

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