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Trends in beta-hemolytic Streptococcus infections within Veterans’ Affairs medical centers from 2009 to 2018

Published online by Cambridge University Press:  06 September 2021

GiGi Yam ,
Bethany A. Wattengel ,
Michael T. Carter ,
John A. Sellick ,
Alan J. Lesse  and
Kari A. Mergenhagen
GiGi Yam
Affiliation:
Department of Pharmacy, Western NY VA Healthcare System, Buffalo, New York
Bethany A. Wattengel
Affiliation:
Department of Pharmacy, Western NY VA Healthcare System, Buffalo, New York
Michael T. Carter
Affiliation:
Department of Pharmacy, Western NY VA Healthcare System, Buffalo, New York
John A. Sellick*
Affiliation:
Department of Infectious Diseases, Western NY VA Healthcare System, Buffalo, New York University at Buffalo, Jacobs School of Medicine, Buffalo, New York
Alan J. Lesse
Affiliation:
Department of Infectious Diseases, Western NY VA Healthcare System, Buffalo, New York University at Buffalo, Jacobs School of Medicine, Buffalo, New York
Kari A. Mergenhagen*
Affiliation:
Department of Pharmacy, Western NY VA Healthcare System, Buffalo, New York
*
Author for correspondence: Kari A. Mergenhagen, E-mail: Kari.Mergenhagen@va.gov. Or John A. Sellick, E-mail: John.Sellick@va.gov
Author for correspondence: Kari A. Mergenhagen, E-mail: Kari.Mergenhagen@va.gov. Or John A. Sellick, E-mail: John.Sellick@va.gov
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Abstract

Objective:

The purpose of this study was to describe the recent trends of invasive and noninvasive β-hemolytic Streptococcus cultures in the Veterans’ Affairs (VA) cohort from 2009 to 2018.

Design:

Retrospective cohort study from January 1, 2009, to January 1, 2019.

Setting:

Veterans’ Affairs medical centers.

Patients or participants:

All patients aged 18 years and older with cultures positive for β-hemolytic Streptococcus at a VA facility were included in the study.

Intervention(s):

Data were retrieved from the VA Corporate Data Warehouse using structure query language through the SQL Server Management Studio software.

Results:

Between 2009 and 2018, there were 40,625 patients with cultures with β-hemolytic Streptococcus. The median age was 64 years (interquartile range [IQR], 55–71) and the median Charlson comorbidity index was 4 (IQR, 2–7). Distributions for each type of β-hemolytic Streptococcus based on site of culture are provided. The 30-day all-cause mortality rate from all invasive β-hemolytic Streptococcus cases was 2.3%, and the 90-day all-cause mortality rate was 4.4%. The 30- and 90-day all-cause mortality rates for Streptococcus cases were higher for group A (3.9% and 6.1% respectively) and for groups C and G combined (3.2% and 6.1%, respectively) than for group B (2.0% and 4.0%, respectively).

Conclusions:

Trends of cultures for invasive and noninvasive β-hemolytic Streptococcus suggest an association with disease and mortality. The burden associated with β-hemolytic Streptococcus infections should not be underestimated.

Type
Original Article
Information
Infection Control & Hospital Epidemiology , Volume 42 , Issue 11 , November 2021 , pp. 1356 - 1360
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Copyright
© The Author(s), 2021. Published by Cambridge University Press on behalf of The Society for Healthcare Epidemiology of America

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References

Active bacterial core surveillance report, Emerging Infections Program Network, group A Streptococcus, 1997–2017, 1998–2018. Centers for Disease Control and Prevention website. https://www.cdc.gov/abcs/reports-findings/surv-reports.html. Accessed January 14, 2021.Google Scholar
Active bacterial core surveillance report, Emerging Infections Program Network, group B Streptococcus, 1997–2017, 1998–2018. Centers for Disease Control and Prevention website. https://www.cdc.gov/abcs/reports-findings/surv-reports.html. Accessed January 14, 2021.Google Scholar
Jump, RLP, Wilson, BM, Baechle, D, et al. Risk factors and mortality rates associated with invasive group B Streptococcus infections among patients in the US Veterans’ Health Administration. JAMA Netw Open 2019;2(12):e1918324-e.10.1001/jamanetworkopen.2019.18324CrossRefGoogle Scholar
Skoff, TH, Farley, MM, Petit, S, et al. Increasing burden of invasive group B streptococcal disease in nonpregnant adults, 1990–2007. Clin Infect Dis 2009;49:85–92.10.1086/599369CrossRefGoogle Scholar
Francois Watkins, LK, McGee, L, Schrag, SJ, et al. Epidemiology of invasive group B streptococcal infections among nonpregnant adults in the United States, 2008–2016. JAMA Intern Med 2019;179:479–488.10.1001/jamainternmed.2018.7269CrossRefGoogle ScholarPubMed
Nelson, GE, Pondo, T, Toews, K-A, et al. Epidemiology of invasive group A streptococcal infections in the United States, 2005–2012. Clin Infect Dis 2016;63:478–486.10.1093/cid/ciw248CrossRefGoogle ScholarPubMed
O’Loughlin, RE, Roberson, A, Cieslak, PR, et al. The epidemiology of invasive group A streptococcal infection and potential vaccine implications: United States, 2000–2004. Clin Infect Dis 2007;45:853–862.10.1086/521264CrossRefGoogle ScholarPubMed
Schwartz, IS, Keynan, Y, Gilmour, MW, Dufault, B, Lagace-Wiens, P. Changing trends in beta-hemolytic streptococcal bacteremia in Manitoba, Canada: 2007–2012. Int J Infect Dis 2014;28:211–213.10.1016/j.ijid.2014.03.1376CrossRefGoogle ScholarPubMed
Oppegaard, O, Mylvaganam, H, Kittang, BR. Beta-haemolytic group A, C and G streptococcal infections in western Norway: a 15-year retrospective survey. Clin Microbiol Infect 2015;21:171–178.10.1016/j.cmi.2014.08.019CrossRefGoogle Scholar
Oppegaard, O, Mylvaganam, H, Skrede, S, Lindemann, PC, Kittang, BR. Emergence of a Streptococcus dysgalactiae subspecies equisimilis stG62647-lineage associated with severe clinical manifestations. Sci Rep 2017;7:7589.10.1038/s41598-017-08162-zCrossRefGoogle ScholarPubMed
Lambertsen, LM, Ingels, H, Schonheyder, HC, Hoffmann, S. Nationwide laboratory-based surveillance of invasive beta-haemolytic streptococci in Denmark from 2005 to 2011. Clin Microbiol Infect 2014;20:O216–O223.10.1111/1469-0691.12378CrossRefGoogle ScholarPubMed
Verani, JR, McGee, L, Schrag, SJ. Prevention of perinatal group B streptococcal disease—revised guidelines from CDC, 2010. MMWR Recommend Rep 2010;59(Rr-10):1–36.Google Scholar
Oppegaard, O, Skrede, S, Mylvaganam, H, Kittang, BR. Temporal trends of beta-haemolytic streptococcal osteoarticular infections in western Norway. BMC Infect Dis 2016;16:535.10.1186/s12879-016-1874-7CrossRefGoogle ScholarPubMed
Ekelund, K, Skinhoj, P, Madsen, J, Konradsen, HB. Invasive group A, B, C, and G streptococcal infections in Denmark 1999–2002: epidemiological and clinical aspects. Clin Microbiol Infect 2005;11:569–576.10.1111/j.1469-0691.2005.01169.xCrossRefGoogle Scholar
Rantala, S, Vuopio-Varkila, J, Vuento, R, Huhtala, H, Syrjanen, J. Predictors of mortality in beta-hemolytic streptococcal bacteremia: a population-based study. J Infect 2009;58:266–272.10.1016/j.jinf.2009.01.015CrossRefGoogle ScholarPubMed
Broyles, LN, Van Beneden, C, Beall, B, et al. Population-based study of invasive disease due to β-hemolytic streptococci of groups other than A and B. Clin Infect Dis 2009;48:706–712.10.1086/597035CrossRefGoogle ScholarPubMed
Bencardino, D, Di Luca, MC, Petrelli, D, Prenna, M, Vitali, LA. High virulence gene diversity in Streptococcus pyogenes isolated in central Italy. Peer J 2019;7:e6613.10.7717/peerj.6613CrossRefGoogle ScholarPubMed