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Assessment of Screening Tests for Transfusion-Associated Non-A Non-B Hepatitis

Published online by Cambridge University Press:  10 March 2009

Frederic Fleurette ,
Pierre Durieux ,
Renaldo N. Battista ,
Jean-Pierre Benhamou ,
Françoise Degos ,
Christian Brechot ,
Anne-Marie Courouce ,
Christian Janot  and
Christian Trepo
Frederic Fleurette
Affiliation:
Agence Nationale pour le Développement de l'Evaluation Medicate, Paris
Pierre Durieux
Affiliation:
Agence Nationale pour le Développement de l'Evaluation Medicate, Paris
Renaldo N. Battista
Affiliation:
Montreal General Hospital, Montreal
Jean-Pierre Benhamou
Affiliation:
Hopital Beaujon, Clichy
Françoise Degos
Affiliation:
Hopital Beaujon, Clichy
Christian Brechot
Affiliation:
CHU Necker Enfants Malades, Paris
Anne-Marie Courouce
Affiliation:
Institut National de Transfusion Sanguine, Paris
Christian Janot
Affiliation:
CRTS, Vandoeuvre les Nancy
Christian Trepo
Affiliation:
Hôtel Dieu, Lyon
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Abstract

Non-A non-B hepatitis is the most common serious sequela of blood transfusion, and its screening has become an essential goal of blood transfusion centers. Before 1989, two surrogate screening tests (for alanine aminotransferase and for antibody to hepatitis B core antigen) were used; in 1989, a direct test for the antibody to hepatitis C virus (the main agent of this hepatitis) was developed. The French National Agency for the Development of Medical Evaluation undertook an investigation to determine the optimal prevention strategy for posttransfusion non-A and non-B hepatitis (PTH). A detailed literature review was performed, complemented by expert group opinion. The performance of each test was derived indirectly by calculating the number of cases of PTH averted by each test. Hepatitis C virus testing is probably the most promising strategy, but different policies can be developed given the uncertainties of scientific data. Cost considerations should be taken into account in identifying the best screening strategy.

Type
General Essays
Information
International Journal of Technology Assessment in Health Care , Volume 9 , Issue 4 , Fall 1993 , pp. 479 - 489
Copyright
Copyright © Cambridge University Press 1993

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References

REFERENCES

1.Aach, R. D., Szmuness, W., Mosley, J. W., et al. Serum alanine amino-transferase of donors in relation to the risk of non-A, non-B hepatitis in recipients: The Transfusion-Transmitted Viruses Study. New England Journal of Medicine, 1981, 304, 989–94.CrossRefGoogle Scholar
2.Alter, H. J.Posttransfusion hepatitis: Clinical features, risk and donor testing. Progress in Clinical and Biological Research, 1985, 182, 47–61.Google ScholarPubMed
3.Alter, H. J. Transfusion-associated non-A, non-B hepatitis: The first decade. In Zuckerman, A. J. (ed.), Viral hepatitis and liver disease. New York: Alan R. Liss, 1988, 537–42.Google Scholar
4.Alter, H. J., Hadler, S. C., Francis, D. P., & Maynard, J. E.The epidemiology of non-A, non-B hepatitis in the United States. Progress in Clinical and Biological Research, 1985, 182, 71–79.Google ScholarPubMed
5.Alter, H. J., Jett, B. W., Polito, A. J., et al. Analysis of the role of hepatitis C virus in transfusion-associated hepatitis. In Hollinger, F. B., Lemon, S. M., & Margolis, H. (eds.), 1990 International symposium on viral hepatitis and liver diseases: Contemporary issue and future prospects. Baltimore: Williams and Wilkins, 1991, 396–402.Google Scholar
6.Alter, H. J., Purcell, R. H., Holland, P. V., et al. Donor transaminase and recipient hepatitis: Impact on blood transfusion services. Journal of the American Medical Association, 1981, 246, 630–34.CrossRefGoogle ScholarPubMed
7.Aymard, J. P., Janot, G., Gayet, S., et al. Post-transfusion non-A, non-B hepatitis after cardiac surgery. Prospective analysis of donor blood anti-HBc antibody as a predictive indicator of the occurrence of non-A, non-B hepatitis in recipients. Vox Sanguinis, 1986, 51, 236–38.Google ScholarPubMed
8.Berman, M., Alter, H. J., Ishak, K. G., et al. The chronic sequelae of non-A, non-B hepatitis. Annals of Internal Medicine, 1979, 91, 1–6.CrossRefGoogle ScholarPubMed
9.Choo, Q. L., Kuo, G., Weiner, A. J., et al. Isolation of a cDNA clone derived from a blood-borne non-A non-B viral hepatitis genome. Science, 1989, 244, 359–62.CrossRefGoogle ScholarPubMed
10.Colombo, M., Oldani, S., Donato, M. F., et al. A multicenter prospective study of post transfusion hepatitis in Milan. Hepatology, 1987, 7, 709–12.CrossRefGoogle Scholar
11.Descos, B., Scotto, J., Fayol, V., et al. Anti-HBc screening for the prevention of perinatal transmission of hepatitis B virus in France. Infection, 1987, 15, 434–39.CrossRefGoogle ScholarPubMed
12.Esteban, J. I., Gonzalez, A., Hernandez, J. M., et al. Evaluation of antibodies to hepatitis C virus in a study of transfusion-associated hepatitis. New England Journal of Medicine, 1990, 323, 1107–12.CrossRefGoogle Scholar
13.Feinman, S. V., Berris, B., & Bojarski, S.Posttransfusion hepatitis in Toronto, Canada. Gastroenterology, 1988, 95, 463–64.CrossRefGoogle ScholarPubMed
14.Feinstone, S. M., Kapikian, A. Z., Purcell, R. H., et al. Transfusion associated hepatitis not due to viral hepatitis type A or B. New England Journal of Medicine, 1975, 292, 767–70.CrossRefGoogle ScholarPubMed
15.Fleurette, F., & Durieux, P.Prevention des hepatites non-A non-B post-transfusionnelles. Paris: ANDEM, Rapport remis au Ministere de la Sante, 1991.Google Scholar
16.Gayet, S., Aymard, J. P., Janot, C., et al. Incidence de Il'hepatite non-A, non-B posttransfusionnelle en chirurgie cardiaque. Etude prospective de Il'interet du dosage de Il'alanine aminotransferase serique et de la recherche d'anticorps anti-HBc chez les donneurs de sang. Revue Francaise de Transfusion et d'Immuno-hematologie, 1986, 29, 485–94.CrossRefGoogle Scholar
17.Hernandez, J. M., Piqueras, J., Carrera, A., & Triginer, J.Post-transfusion hepatitis in Spain. A prospective study. Vox Sanguinis, 1983, 44, 231–37.CrossRefGoogle Scholar
18.Hollinger, F. B., Mosley, J. W., Szmuness, W., et al. Non-A, non-B hepatitis following blood transfusion: Risk factors associated with donor characteristics. In Szmuness, W., Alter, H. J., & Maynard, J. E. (eds.), Viral hepatitis. 1981 International symposium. Philadelphia, PA: Franklin Institute Press, 1982, 361–76.Google Scholar
19.Hoofnagle, J. H., & Alter, H. J.Chronic non-A, non-B hepatitis. Progress in Clinical and Biological Research, 1985, 129, 63–69.Google Scholar
20.Hoofnagle, J. H., Seefe, L. B., Bales, Z. B., & Zimmerman, H. J.Type B hepatitis after transfusion with blood containing antibody to hepatitis B core antigen. New England Journal of Medicine, 1978, 295, 1379–83.CrossRefGoogle Scholar
21.Hopkins, R., Kane, E., Robertson, A. E., & Haase, G.Hepatitis B virus transmitted by HBsAq-negative blood containing anti-HBc. Medical Laboratory Sciences, 1982, 39, 61–62.Google ScholarPubMed
22.Hoyos, M., Sarrion, J. V., Perez-Castellanos, T., et al. Prospective assessment of donor blood screening for antibody to hepatitis B core antigen as a means of preventing posttransfusion non-A, non-B hepatitis. Hepatology, 1989, 9, 449–51.CrossRefGoogle ScholarPubMed
23.Ito, S., Tsuji, Y., Iwasaki, A., et al. Relationship between guanase activity in donor blood and the incidence of posttransfusional non-A, non-B hepatitis, and a possible method for preventing posttransfusional hepatitis. Hepatology, 1986, 6, 990–93.CrossRefGoogle Scholar
24.Kiyosawa, K., Sodemaya, T., Tanaka, E., et al. Interrelationship of blood transfusion, non-A non-B hepatitis and hepatocellular carcinoma: Analysis by detection of antibody to hepatitis C virus. Hepatology, 1990, 12, 671–75.CrossRefGoogle ScholarPubMed
25.Knodell, R. G., Conrad, M. E., Dienstag, J. L., et al. Etiological spectrum of post transfusion hepatitis. Gastroenterology, 1975, 69, 1278–81.CrossRefGoogle ScholarPubMed
26.Knodell, R. G., Conrad, M. E., & Ishak, K. G.Development of chronic liver disease after acute non-A non-B post-transfusion hepatitis: Role of gamma globulin prophylaxis in its prevention. Gastroenterology, 1977, 72, 902.CrossRefGoogle ScholarPubMed
27.Korets, R. L., Stone, O.,&Gitnick, G. L.The long term course of chronic post-transfusion hepatitis. Gastroenterology, 1980, 79, 893.CrossRefGoogle Scholar
28.Koziol, D. E., Holland, P. V., Alling, D. W., et al. Antibody to hepatitis B core antigen as a paradoxical marker for non-A, non-B hepatitis agents in donated blood. Annals of Internal Medicine, 1986, 104, 488–95.CrossRefGoogle ScholarPubMed
29.Kuo, G., Choo, Q. L., Alter, H. J., et al. An assay for circulating antibodies to a major etiologic virus of human non-A, non-B hepatitis. Science, 1989, 244, 362–64.CrossRefGoogle Scholar
30.Lai, M. E., Farci, P., Figus, A., et al. Hepatitis B virus DNA in the serum of Sardinian blood donors negative for the hepatitis B surface antigen. Blood, 1989, 73, 17–19.CrossRefGoogle ScholarPubMed
31.Mattsson, L., Aberg, B., von Sydow, M., & Weiland, O.Incidence of hepatitis and seroconversion to hepatitis C virus after open-heart surgery in transfused and non transfused patients in Sweden. Scandinavian Journal of Infectious Diseases, 1991, 23, 25–29.CrossRefGoogle ScholarPubMed
32.Mattsson, L., Aberg, B., Weiland, O., et al. Non-A, non-B hepatitis after open-heart surgery in Stockholm. Declining incidence after introduction of restrictions for blood donations due to the human. Scandinavian Journal of Infectious Diseases, 1988, 20, 371–76.CrossRefGoogle ScholarPubMed
33.Mattsson, L., Weiland, O., & Glaumann, H.Chronic non-A, non-B hepatitis developed after transfusions, illicit self-injections or sporadically outcome during long-term followup. A comparison. Liver, 1989, 9, 120–127.CrossRefGoogle ScholarPubMed
34.Rakela, J., & Redeker, A. G.Chronic liver disease after acute non-A non-B viral hepatitis. Gastroenterology, 1979, 77, 1200.CrossRefGoogle ScholarPubMed
35.Realdi, G., Alberti, A., Rugge, M., et al. Long term follow-up of acute and chronic non-A, non-B post-transfusion hepatitis: Evidence of progression to liver cirrhosis. Gut, 1982, 23, 270.CrossRefGoogle ScholarPubMed
36.Reesink, H. W., Leentvaar-Kuypers, A., van der Poel, C. L., et al. Non-A, non-B post-transfusion hepatitis in open heart surgery patients in the Netherlands: Preliminary results of a prospective study. In Zuckerman, A. J. (ed.), Viral hepatitis and liver disease. New York: Alan R. Liss, 1988, 558–60.Google Scholar
37.Robinson, W. S.The enigma of non-A, non-B hepatitis. Journal of Infectious Diseases, 1982, 145, 387–95.CrossRefGoogle ScholarPubMed
38.Sirchia, G., Giovanetti, A. M., Parravicini, A., et al. Prospective evaluation of posttransfusion hepatitis. Transfusion, 1991, 31, 299–302.CrossRefGoogle ScholarPubMed
39.Stevens, C. E., Aach, R. D., Hollinger, F. B., et al. Hepatitis B virus antibody in blood donors and the occurrence of non-A, non-B hepatitis in transfusion recipients. Annals of Internal Medicine, 1984, 101, 733–38.CrossRefGoogle ScholarPubMed
40.Sugg, U., Schenzle, D., & Hess, G.Antibodies to hepatitis B core antigens in blood donors screened for alanine aminotransferase level and hepatitis non-A, non-B in recipients. Transfusion, 1988, 25, 386–88.CrossRefGoogle Scholar
41.Sun, C. F., Pao, C. C., Wu, S. Y., & Liaw, Y. F.Screening for hepatitis B virus in healthy blood donors by molecular DNA hybridization analysis. Journal of Clinical Microbiology, 1988, 56, 1848–52.CrossRefGoogle Scholar
42.Tabor, E.The three viruses of non-A, non-B hepatitis. Lancet, 1985, 1, 743–45.CrossRefGoogle ScholarPubMed
43.Tateda, A., Kikichi, K., Numazaki, Y., et al. Non-B hepatitis in Japanese recipients of blood transfusions: Clinical and serologic studies after the introduction of laboratory screening of donor blood for hepatitis B surface antigen. Journal of Infectious Diseases, 1979, 139, 511–18.CrossRefGoogle ScholarPubMed
44.van der Poel, C. L., Reesink, H. W., Lelie, P. N., et al. Anti-hepatitis C antibodies and non-A, non-B post-transfusion hepatitis in the Netherlands. Lancet, 1989, 2, 297–98.CrossRefGoogle ScholarPubMed
45.Weiner, A. J., Kuo, G., Bradley, D. W., et al. Detection of hepatitis C viral sequences in non-A, non-B hepatitis. Lancet, 1990, 335, 1–3.CrossRefGoogle ScholarPubMed
46.Wejstal, R., Lindberg, J., Lundin, P., & Norkrans, G.Chronic non-A non-B hepatitis. A long term follow-up study in 49 patients. Scandinavian Journal of Infectious Diseases, 1987, 22, 1115-22.Google ScholarPubMed
47.Widell, A., Sundstrom, G., Hanson, B. G., et al. Post-transfusion hepatitis type non-A, non-B in southern Sweden: Occurrence and clinical significance. Scandinavian Journal of Infectious Diseases, 1987, 19, 603–10.CrossRefGoogle ScholarPubMed
48.Widell, A., Sundstrom, G., Hanson, B. G., et al. Relation between donor transaminase and recipient hepatitis non-A, non-B in Sweden. Vox Sanguinis, 1988, 54, 154–59.CrossRefGoogle ScholarPubMed