Hostname: page-component-78c5997874-xbtfd Total loading time: 0 Render date: 2024-11-15T06:47:52.416Z Has data issue: false hasContentIssue false

A Cost-Effectiveness Analysis of Neonatal ECMO Using Existing Evidence

Published online by Cambridge University Press:  10 March 2009

Sarah Howard
Affiliation:
National Perinatal Epidemiology Unit
Miranda Mugford
Affiliation:
National Perinatal Epidemiology Unit
Charles Normand
Affiliation:
London School of Hygiene and Tropical Medicine
Diana Elbourne
Affiliation:
National Perinatal Epidemiology Unit
Adrian Grant
Affiliation:
University of Aberdeen
David Field
Affiliation:
University of Leicester
Ann Johnson
Affiliation:
National Perinatal Epidemiology Unit

Abstract

A cost-effectiveness analysis is part of the U.K. ECMO Trial. In preparation for this analysis, existing evidence on the costs and effectiveness of neonatal ECMO was evaluated. ECMO appears to be more costly but may be more or less effective than conventional treatment. No case can be made for introducing ECMO before trial results are available.

Type
General Essays
Copyright
Copyright © Cambridge University Press 1996

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

1.Andrews, A. F., Nixon, C. A., Cilley, R. E. et al. One- to three-year outcome for 14 neonatal survivors of extracorporeal membrane oxygenation. Pediatrics, 1986, 78, 692–98.CrossRefGoogle ScholarPubMed
2.Bartlett, R. H., Roloff, D. W., Cornell, R. G. et al. Extracorporeal circulation in neonatal respiratory failure: A prospective randomised study. Pediatrics, 1985, 76, 479–87.CrossRefGoogle Scholar
3.Bifano, E. M., Hakanson, D. O., Hingre, R. V., & Gross, S. I.Prospective randomized controlled trial of conventional treatment or transport for ECMO in infants with persistent pulmonary hypertension (PPHN). Pediatric Research, 1992, 31, 196A.Google Scholar
4.Bifano, E. M., & Pfannenstiel, A.Duration of hyperventilation and outcome in infants with persistent pulmonary hypertension. Pediatrics, 1988, 81, 657–61.Google ScholarPubMed
5.Boedy, R. F., Howell, C. G., & Kanto, W. P.Hidden mortality rate associated with extracorporeal membrane oxygenation. Journal of Pediatrics, 1990, 117, 462–64.CrossRefGoogle ScholarPubMed
6.Boggs, K. U., & Visser, V. E.Extracorporeal membrane oxygenation treatment: One-year outcomes for North Carolina infants. North Carolina Medical Journal, 1991, 52, 423–26.Google ScholarPubMed
7.Butt, W., Mee, R., McDougall, P. et al. ECMO in newborn infants: The Melbourne experience. Journal of Paediatrics and Child Health, 1992, 28, 426-28.CrossRefGoogle ScholarPubMed
8.Chevalier, J-Y., Durandy, Y., Batisse, A. et al. Preliminary report: Extracorporeal lung support for neonatal acute respiratory failure. Lancet, 1990, 335, 1364–66.CrossRefGoogle ScholarPubMed
9.Cornish, J. D., Carter, J. M.,Gerstmann, D. R., & Null, D. M.Extracorporeal membrane oxygenation as a means of stabilizing and transporting high risk neonates. Transactions of the American Society for Artificial Internal Organs, 1991, 37, 564–68.Google ScholarPubMed
10.Cornish, J. D., Clark, R. H., Ricketts, R. R. et al. Extracorporeal membrane oxygenation service at Egleston: Two years' experience. Journal of the Medical Association of Georgia, 1993, 82, 471–76.Google ScholarPubMed
11.Dworetz, A. R., Moya, F. R., Sabo, B. et al. Survival of infants with persistent pulmonary hypertension without extracorporeal membrane oxygenation. Pediatrics, 1989, 84, 16.CrossRefGoogle ScholarPubMed
12.Elbourne, D.The UK Collaborative ECMO trial. Midwives Chronicle, 1994, 107, 312–16.Google ScholarPubMed
13.Flusser, H., Dodge, N. N., Engle, W. E. et al. Neurodevelopment outcome and respiratory morbidity for extracorporeal membrane oxygenation survivors at 1 year of age. Journal of Perinatology, 1993, 13, 266–71.Google Scholar
14.Fordham, R., Field, D. J., Hodges, S. et al. Costs of neonatal care across a health authority. Journal of Public Health Medicine, 1992, 14, 127–30.Google ScholarPubMed
15.Frenckner, B., Ehren, H., & Palmer, K.Extracorporeal membrane oxygenation in a European center: Clinical experience. European Journal of Pediatric Surgery, 1991, 1, 1520.CrossRefGoogle Scholar
16.Glass, P., Miller, M., & Short, B.Morbidity for survivors of extracorporeal membrane oxygenation: Neurodevelopmental outcome at 1 year of age. Pediatrics, 1989, 73, 7278.CrossRefGoogle Scholar
17.Grant, J., Hoskyns, W., Pearson, G. A. et al. Outcome after neonatal extracorporeal membrane oxygenation (abstract). International ECMO Conference: Third European Congress of Extracorporeal Life Support. University of Leicester, 1994, 8.Google Scholar
18.Greenough, A., & Emery, E.ECMO and the outcome of mechanical ventilation in infants of birthweight over 2kg. Lancet, 1990, 336, 760.CrossRefGoogle Scholar
19.Griffin, M. P., Minifee, P. K., Landry, S. H. et al. Neurodevelopmental outcome in neonates after extracorporeal membrane oxygenation: Cranial magnetic resonance imaging and ultrasonography correlation. Journal of Pediatric Surgery, 1992, 27, 3335.CrossRefGoogle ScholarPubMed
20.Guyatt, G., Sackett, D., Sinclair, J. S. et al. User’s Guide to the Medical Literature. IX: New method for grading health care recommendations. Journal of the American Medical Association, 1995, 274, 18001805.Google Scholar
21.Kanto, W. P., Boedy, R. F., & Howell, C. G.The neonatal ECMO experience at MCG: The first fifty patients. Journal of the Medical Association of Georgia, 1990, 79, 379–83.Google ScholarPubMed
22.Kerr, S., Crawford, M., Currie, B. et al. ECMO in newborn infants: The New South Wales experience. Journal of Paediatrics and Child Health, 1992, 28, 429–31.CrossRefGoogle ScholarPubMed
23.Kirkpatrick, B. V., Krummel, T. M., Mueller, D. G. et al. Use of extracorporeal membrane oxygenation for respiratory failure in infants. pediatrics, 1983, 72, 872–76.CrossRefGoogle Scholar
24.Marsh, T. D., Pai, M. S., Austin, T. L. et al. Extracorporeal membrane oxygenation in the neonate. Journal of the South Carolina Medical Association, 1990, 86, 617–19.Google ScholarPubMed
25.O'Rourke, P. P., Crone, R. K., Vacanti, J. P. et al. Extracorporeal membrane oxygen ation and conventional medical therapy in neonates with persistent pulmonary hypertension of the newborn: A prospective randomized study. Pediatrics, 1989, 84, 957–63.CrossRefGoogle Scholar
26.Oxman, A. (ed.). Cochrane collaboration handbook. Oxford: Cochrane Collaboration, 1994.Google Scholar
27.Pearson, G. D., & Short, B.L.An economic analysis of extracorporeal membrane oxygenation. Journal of Intensive Care Medicine, 1987, 2, 116–20.CrossRefGoogle Scholar
28.Pharoah, P. O. D., Stevenson, R. C., Cooke, R. W. I., & Sandhu, B.Costs and benefits of neonatal intensive care. Archives of Disease in Childhood, 1988, 63, 715–18.CrossRefGoogle ScholarPubMed
29.Schulz, K. F., Chalmers, I., Hayes, R. J., & Altman, D. G.Empirical evidence of bias: Dimensions of methodological quality associated with estimates of treatment effects in controlled trials. Journal of the American Medical Association, 1995, 273, 408–12.CrossRefGoogle ScholarPubMed
30.Schumacher, R. E., Palmer, T. W., Roloff, D. W. et al. Follow-up of infants treated with extracorporeal membrane oxygenation for newborn respiratory failure. Pediatrics, 1991, 87, 451–57.CrossRefGoogle ScholarPubMed
31.Sosnowski, A. W., Bonser, S. J., Field, D. J. et al. Extracorporeal membrane oxygenation. British Medical Journal, 1990, 301, 303–04.CrossRefGoogle ScholarPubMed
32.Wung, J-T., James, L. S., Kilchevsky, E., & James, E.Management of infants with severe respiratory failure and persistence of the fetal circulation, without hyperventilation. Pediatrics, 1985, 76, 488–94.CrossRefGoogle ScholarPubMed