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Increasing the generalizability of economic evaluations: Recommendations for the design, analysis, and reporting of studies

Published online by Cambridge University Press:  26 April 2005

Michael Drummond ,
Andrea Manca  and
Mark Sculpher
Michael Drummond
Affiliation:
University of York
Andrea Manca
Affiliation:
University of York
Mark Sculpher
Affiliation:
University of York
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Abstract

Objectives: Health technology assessment (HTA) is increasingly an international activity, and HTA agencies collaborate to avoid unnecessary duplication of effort. However, the sharing of the results from HTAs raises questions about their generalizability; namely, are the results of an HTA undertaken in one country relevant to another?

Methods: This study presents recommendations for increasing the generalizability of economic evaluations. They represent an important component of HTAs and are commonly thought to have limited generalizability.

Results: Recommendations are given for studies using patient-level data (i.e., evaluations conducted alongside clinical trials) and for studies using decision analytic modeling.

Conclusions: If implemented, the recommendations would increase the value for investments in HTA.

Keywords

Cost-effectiveness analysisClinical trialsModeling studiesDecision making
Type
GENERAL ESSAYS
Information
International Journal of Technology Assessment in Health Care , Volume 21 , Issue 2 , April 2005 , pp. 165 - 171
Copyright
© 2005 Cambridge University Press

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