Hostname: page-component-78c5997874-g7gxr Total loading time: 0 Render date: 2024-11-15T17:35:26.924Z Has data issue: false hasContentIssue false
  • English
  • Français

Neonatal Surfactant Deficiency and Surfactant Replacement Therapy

Published online by Cambridge University Press:  10 March 2009

Mikko Hallman ,
Maija Pohjavuori ,
Kristiina Bry  and
T. Allen Merritt
Mikko Hallman
Affiliation:
University of Helsinki
Maija Pohjavuori
Affiliation:
University of Helsinki
Kristiina Bry
Affiliation:
University of Helsinki
T. Allen Merritt
Affiliation:
University of California, San Diego
Get access Rights & Permissions [Opens in a new window]

Extract

For the past 25 years, attempts have been made to treat respiratory distress syndrome (RDS) by administration of surfactant into the airways. This practice is not yet an accepted form of therapy. Lack of generally available surfactant during the present era of prospective studies will hopefully decrease the therapeutic misuse of this novel medicine.

Type
Neonatal Disorders of Respiration
Information
International Journal of Technology Assessment in Health Care , Volume 7 , Supplement S1 , January 1991 , pp. 21 - 25
Copyright
Copyright © Cambridge University Press 1991

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

1.Enhorning, G., Sherman, A., Possmayer, F., Dunn, M., Chen, C. P., & Milligan, J.Prevention of neonatal respiratory distress syndrome by tracheal instillation of surfactant: a randomized clinical trial. Pediatrics, 1985, 76, 145–53.Google Scholar
2.Fujiwara, T. Surfactant replacement in neonatal RDS. In Robertson, B., Van Golde, L. M. G., & Batenburg, J. J. (eds.), Pulmonary surfactant. Amsterdam: Elsevier, 1984, 479–503.Google Scholar
3.Hallman, M., Merritt, T. A., Järvenpää, A.-L., Boynton, B., Mannino, F., Gluck, L., Moore, T., & Edwards, D.Exogenous human surfactant for treatment of severe respiratory distress syndrome: a randomized prospective trial. The Journal of Pediatrics, 1985, 106, 963–69.Google Scholar
4.Hallman, M., Merritt, T. A., Pohjavuori, M., & Gluck, L.Effect of surfactant substitution on lung effluent phospholipids in respiratory distress syndrome: evaluation of surfactant phospholipid turnover, pool size, and the relationship to severity of respiratory failure. Pediatric Research, 1986, 20, 1228–35.CrossRefGoogle ScholarPubMed
5.Hallman, M., Spragg, R., Harrell, J. H., Moser, K. M., & Gluck, L.Evidence of lung surfactant abnormality in respiratory failure. Journal of Clinical Investigations, 1982, 70, 673–83.Google Scholar
6.Ikegami, M., Jobe, A., & Berry, D.A protein that inhibits surfactant in respiratory distress syndrome. Biology of the Neonate, 1986, 50, 121–29.CrossRefGoogle ScholarPubMed
7.Jobe, A. Surfactant in developing lung. In Thibeault, D. W. & Gregory, G. A. (eds.), Neonatal pulmonary care. Norwalk, CT: Appleton-Century-Crofts, 1986, 75–99.Google Scholar
8.Jobe, A., Ikegami, M., Glatz, T., Yoshida, Y., Diakomanolis, E., & Padbury, J.Duration and characteristics of treatment of premature lambs with natural surfactant. Journal of Clinical Investigations, 1981, 67, 370–75.CrossRefGoogle ScholarPubMed
9.Jobe, A., Ikegami, M., Jacobs, H., & Jones, S.Surfactant and pulmonary blood flow distributions following treatment of premature lambs with natural surfactant. Journal of Clinical Investigations, 1984, 73, 848–56.CrossRefGoogle ScholarPubMed
10.Kankaanpää, K., & Hallman, M.Respiratory distress syndrome in very low birth weight infants with occasionally normal surfactant phospholipids. European Journal of Pediatrics, 1982, 139, 31–34.CrossRefGoogle ScholarPubMed
11.Merritt, T. A., Hallman, M., Bloom, B. T., Berry, C., Benirschke, K., Sahn, D., Key, T., Edwards, D., Jarvenpaa, A.-L., & Pohjavuori, M., et al. Prophylactic treatment of very premature infants with human surfactant. New England Journal of Medicine, 1986, 315, 785–90.CrossRefGoogle ScholarPubMed
12.Notter, R. H., & Shapiro, D. L.Lung surfactants for replacement therapy. Clinical Perinatology, 1987, 14, 433–79.CrossRefGoogle ScholarPubMed
13.Robertson, B. Neonatal pulmonary mechanics and morphology after experimental therapeutic regimens. In Scarpelli, E. M. & Cosmi, E. V. (eds.), Reviews in perinatal medicine, Vol 4. New York: Raven Press, 1981, 337–79.Google Scholar
14.Raju, T. N. K., Vidyasagar, D., Bhat, R., Sobel, D., McCulloch, K. M., Anderson, M., Maeta, H., Levy, P. S., & Furner, S.Double-blind controlled trial of single-dose treatment with bovine surfactant in severe hyaline membrane disease. The Lancet, 1987, i, 651–55.Google Scholar
15.A. Strayer, D. S., Merritt, T. A., Lwebuga-Mukasa, J., & Hallman, M.Surfactant-anti-surfactant immune complexes in infants with respiratory distress syndrome. American Journal of Pathology, 1986, 122, 353–62.Google ScholarPubMed
16.Ten Centre Study Group. Ten centre trial of artificial surfactant in very premature babies. British Medical Journal, 1987, 294, 991–96.Google Scholar
17.Wilkinson, A., Jenkins, P. A., & Jeffrey, J. A.Two controlled trials of dry artificial surfactant: early and later outcome of babies with surfactant deficiency. The Lancet, 1985, ii, 287–91.Google Scholar