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Immunization of the Neonate

Published online by Cambridge University Press:  14 October 2009

Alexander R. Lawton
Alexander R. Lawton
Affiliation:
Vanderbilt University School of Medicine
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Abstract

The generation of diversity of T and B cells begins early in gestation. Selective restrictions in expression of V genes occur in fetal life, but insufficient clonal diversity is not likely to limit newborn immune capabilities. The functional immaturity of neonatal T and B cells is beginning to be defined. Virgin T cells lack the capacity to produce diverse lymphokines, whereas neonatal B cells are less responsive to the lymphokines that promote terminal differentiation to plasma cells.

Type
Special Section: Vaccines and Public Health: Assessing Technologies and Public Policies
Information
International Journal of Technology Assessment in Health Care , Volume 10 , Issue 1 , Winter 1994 , pp. 154 - 160
Copyright
Copyright © Cambridge University Press 1994

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