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Pharmacists as Agents of Change for Rational Drug Therapy

Published online by Cambridge University Press:  10 March 2009

Helene Levens Lipton ,
Patricia J. Byrns ,
Stephen B. Soumerai  and
Elizabeth A. Chrischilles
Helene Levens Lipton
Affiliation:
University of California, San Francisco
Patricia J. Byrns
Affiliation:
University of Colorado Health Sciences Center
Stephen B. Soumerai
Affiliation:
Harvard Medical School and Harvard Community Health Plan
Elizabeth A. Chrischilles
Affiliation:
University of Iowa
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Abstract

We analyze what is known and unknown about the contribution of the pharmacist as patient educator, physician consultant, and agent to affect patient outcomes in ambulatory settings. The need for pharmacist services is discussed, as are the theoretical underpinnings and quality of the scientific evidence to support their efficacy. The analysis is conducted in the context of a shift in pharmacists' roles from product to patient orientation as well as recent U.S. legislation mandating enhanced pharmacists' roles via drug utilization review for all Medicaid patients. We conclude with a research and action agenda, calling for stronger research designs in evaluating pharmacists' interventions. The shifting paradigm in the pharmacy profession, coupled with the implementation of the Omnibus Budget Reconciliation Act of 1990, provide unique opportunities for rigorous evaluations of pharmacists as agents of change for rational drug therapy.

Type
Special Section: The Rational Use of Therapeutic Drugs
Information
International Journal of Technology Assessment in Health Care , Volume 11 , Issue 3 , Summer 1995 , pp. 485 - 508
Copyright
Copyright © Cambridge University Press 1995

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References

1.Avorn, J., Chen, M., & Hartley, R.Scientific versus commercial sources of influence on the prescribing behavior of physicians. American Journal of Medicine, 1982, 73, 4–8.CrossRefGoogle ScholarPubMed
2.Avorn, J. L., & Soumerai, S. B.Improving drug therapy decisions through educational outreach: A randomized controlled trial of academically-based ‘detailing.’ New England Journal of Medicine, 1983, 308, 1457–63.CrossRefGoogle ScholarPubMed
3.Barnett, G. O., Winickoff, R. N., Morgan, M. M., & Zielstorff, R. D.A computer-based monitoring system for follow-up of elevated blood pressure. Medical Care, 1983, 21, 400–09.CrossRefGoogle ScholarPubMed
4.Barnett, S. Unpublished MSPH thesis proposal. UCHSC, 1994.Google Scholar
5.Bero, L. A., Lipton, H. L., & Bird, J. A.Characterization of geriatric drug-related hospital readmissions. Medical Care, 1991, 29, 989–1003.CrossRefGoogle ScholarPubMed
6.Bigby, J., et al. Assessing the preventability of emergency hospital admissions. American Journal of Medicine, 1987, 83, 1031–36.CrossRefGoogle ScholarPubMed
7.Black, D. M., et al. Compliance to treatment for hypertension in elderly patients: The SHEP pilot study. Journal of Gerontology, 1987, 42, 552–57.CrossRefGoogle Scholar
8.Bond, C. A., & Salinger, R. J.Fluphenazine outpatient clinics: A pharmacist's role. Journal of Clinical Psychiatry, 1979, 40, 501–03.Google ScholarPubMed
9.Borgsdorf, L. R., Miano, J. S., & Knapp, K. K.Pharmacist-managed medication review in a managed care system. American Journal of Hospital Pharmacy, 1994, 51, 772–77.Google Scholar
10.Bötiger, L. E., & Westerholm, B.Drug-induced blood dyscrasias in Sweden. British Medical Journal, 1973, 3, 339–43.CrossRefGoogle Scholar
11.Britton, M. L., & Lurvey, P. L.Impact of medication profile review on prescribing in a general medicine clinic. American Journal of Hospital Pharmacy, 1991, 48, 265–70.Google Scholar
12.Brodie, D. C.Drug utilization review/planning. American Journal of Public Health, 1972, 46, 103–12.Google ScholarPubMed
13.Byrns, P. J. Colorado Annual Report to HCFA, FFY 1993, unpublished.Google Scholar
14.Chrischilles, E. A., Helling, D. K., & Aschoff, C. R.Effect of clinical pharmacy services on the quality of family practice physician prescribing and medication costs. DICP: Annals of Pharmacotherapy, 1989, 23, 417–21.CrossRefGoogle ScholarPubMed
15.Christensen, D. B., Campbell, W. H., Madsen, S., et al. Documenting outpatient problem intervention activities of pharmacists in an HMO. Medical Care, 1981, 19, 104–16.CrossRefGoogle Scholar
16.Christensen, D. B., Fassett, W. E., & Andrews, G. A.A practical billing and payment plan for cognitive services. American Pharmacy, 1993, NS33, 34–40.CrossRefGoogle Scholar
17.Col, N., Fanale, J. E., & Kronholm, P.The role of medication noncompliance and adverse drug reactions in hospitalizations of the elderly. Archives of Internal Medicine, 1990, 150, 841–45.CrossRefGoogle ScholarPubMed
18.Connel, F. A., Blide, L. A., & Hanken, M. A.Clinical correlates of small area variations in population-based admission rates for diabetes. Medical Care, 1984, 22(N10), 939–49.CrossRefGoogle Scholar
19.Cook, T. D., & Campbell, D. T.Quasi-experimentation: Design and analysis issues for field settings. Boston: Houghton Mifflin, 1979.Google Scholar
20.Cooper, J. K., Love, D. W., & Raffoul, P. R.Intentional prescription nonadherence (noncompliance) by the elderly. Journal of the American Geriatrics Society, 1982, 30, 329–33.CrossRefGoogle ScholarPubMed
21.Coster, J. Personal communication, 07 27, 1994.Google Scholar
22.Cunningham, F. G., & Lindheimer, M. D.Hypertension in pregnancy. New England Journal of Medicine, 1992, 326, 927–32.Google ScholarPubMed
23.Currie, J. D. Pharmaceutical care provided in a community pharmacy. Presented at the Iowa Pharmacists Association Annual Meeting, 06 1994.Google Scholar
24.Darnell, J. C., Murray, M. D., Martz, B. L., & Weinberger, M.Medication use by ambulatory elderly: An in-home survey. Journal of the American Geriatrics Society, 1986, 34, 1–4.CrossRefGoogle ScholarPubMed
25.Davidson, F., Haghfelt, T., Gram, L. F., & Brosen, K.Adverse drug reactions and drug non-compliance as primary causes of admission to a cardiology department. European Journal of Clinical Pharmacology, 1988, 34, 83–86.CrossRefGoogle Scholar
26.Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. New England Journal of Medicine, 1993, 329, 977–86.CrossRefGoogle Scholar
27.Dirckx, J. H.Labels for prescribed drugs (letter). Journal of the American Medical Association, 1979, 242, 413–44.CrossRefGoogle Scholar
28. Donabedian, A. The role of outcomes in quality assessment and assurance. Quarterly Review Bulletin, 1992, 11, 356–60.CrossRefGoogle Scholar
29.Donovan, M., Dillon, P., & McGuire, L.Incidence and characteristics of pain in a sample of medical-surgical patients. Pain, 1987, 30, 69–78.Google Scholar
30.Ebersole, P., & Hess, P.Toward healthy aging: Human needs and nursing response. St. Louis: C. V. Mosby, 1981.Google Scholar
31.Edelson, J. T., et al. Long-term cost-effectiveness of various initial monotherapies for mild to moderate hypertension. Journal of the American Medical Association, 1990, 236, 407–13.CrossRefGoogle Scholar
32.Einarson, T. R.Drug-related hospital admissions. Annals of Pharmacotherapy, 1993, 27, 832–39.CrossRefGoogle ScholarPubMed
33.Evans, R. L., Kirk, R. F., Walker, P. W., et al. Medication maintenance of mentally ill patients by a pharmacist in a community setting. American Journal of Hospital Pharmacy, 1976, 33, 635–38.Google Scholar
34.Forstrom, M. J., Ried, L. D., Stergachis, A. S., & Corliss, D. A.Effect of a clinical pharmacist program on the cost of hypertension treatment in an HMO family practice clinic. Drug Intelligence and Clinical Pharmacy, 1990, 24, 304–09.Google Scholar
35.Fortner, C. R., Tarrant, T., & Felton, H. F.Report on an ambulatory clinical pharmacy program and its cost effectiveness. Group Health Journal, 1985, 24, 3–6.Google Scholar
36.Francis, C. K.Making a difference: Managing hypertension in minority patients. American Journal of Medicine, 1990, 88(3B), 1S–2S.CrossRefGoogle ScholarPubMed
37.French, J. R. P. Jr., & Raven, B. The bases of social power. In Cartwright, D. (ed.), Studies in social power. Ann Arbor, MI: Institute for Social Research, 1959, 607–23.Google Scholar
38.Garabedian-Ruffalo, S. M., Gray, D. R., Sax, M. J., & Ruffalo, R. L.Retrospective evaluation of a pharmacist-managed warfarin anticoagulation clinic. American Journal of Hospital Pharmacy 1985, 42, 304–08.Google ScholarPubMed
39.General Accounting Office. Automated prospective review systems offer potential benefits for Medicaid. Washington, DC: GAO, 1994, AIMD-94–130.Google Scholar
40.Gilmore, J. E., Temple, D. J., & Taggart, H. M.A study of drug compliance, including the effect of a treatment card, in elderly patients following discharge home from hospital. Aging, 1989, 1, 153–58.Google ScholarPubMed
41.Gray, D. R., Garabedian-Ruffalo, S. M., & Chretien, S. D.Cost-justification of a clinical pharmacist-managed anticoagulation clinic. Drug Intelligence and Clinical Pharmacy, 1985, 19, 576–80.CrossRefGoogle ScholarPubMed
42.Griffin, M. R., Ray, W. A., & Schaffner, W.Nonsteroidal anti-inflammatory drug use and death from peptic ulcer in elderly persons. Annals of Internal Medicine, 1988, 109, 359–63.CrossRefGoogle ScholarPubMed
43.Gurwitz, J., Soumerai, S. B., & Avorn, J.Improving medication prescribing and utilization in the nursing home. Journal of the American Geriatrics Society, 1990, 38, 542–52.CrossRefGoogle ScholarPubMed
44.Gurwitz, J. H.Suboptimal medication use in the elderly. Journal of the American Medical Association, 1994, 272, 316–17.CrossRefGoogle ScholarPubMed
45.Hallas, J., et al. Drug related hospital admissions: The role of definitions and intensity of data collection, and the possibility of prevention. Journal of Internal Medicine, 1990, 228, 83–90.CrossRefGoogle ScholarPubMed
46.Hammarlund, E. R., Ostrom, J. R., & Kethley, A. J.The effects of drug counseling and other educational strategies on drug utilization of the elderly. Medical Care, 1985, 23, 165–70.CrossRefGoogle ScholarPubMed
47.Hare, E. H., & Willcox, D. R.Do psychiatric inpatients take their pills? British Journal of Psychiatry, 1967, 113, 1435–39.CrossRefGoogle ScholarPubMed
48.Hatoum, H. T., Witte, K. W., & Hutchinson, R. A.Patient care contributions of clinical pharmacists in four ambulatory care clinics. Hospital Pharmacy, 1992, 27, 203–06, 208–09.Google ScholarPubMed
49.Hawe, P., & Higgins, G.Can medication education improve the drug compliance of the elderly? Evaluation of an in hospital program. Patient Education and Counseling, 1990, 16, 151–60.CrossRefGoogle ScholarPubMed
50.Haynes, R. B., Sackett, D. L., & Taylor, D. W.How to detect and manage low patient compliance in chronic illness. Geriatrics, 1980, 355, 91–97.Google Scholar
51.Hemminki, E., & Heikkila, J.Elderly people's compliance with prescriptions and quality of medication. Scandinavian Journal of Social Medicine, 1975, 3, 87–92.CrossRefGoogle ScholarPubMed
52.Hepler, C. D., & Strand, L. M.Opportunities and responsibilities in pharmaceutical care. American Journal of Hospital Pharmacy, 1990, 47, 533–41.Google ScholarPubMed
53.Hood, J. C., & Murphy, J. E.Patient noncompliance can lead to hospital readmissions. Pharmacy, 1978, 52, 79–82.Google ScholarPubMed
54.Horwitz, R. I., Viscoli, C. M., Clemens, J. D., & Sadock, R. T.Developing improved observational methods for evaluating therapeutic effectiveness. American Journal of Medicine, 1990, 89, 630–38.CrossRefGoogle ScholarPubMed
55.Hovland, C. I., Lumsdaine, A. A., & Sheffield, F. D.Experiments in mass communication. Princeton: Princeton University Press, 1949.Google Scholar
56.Hulka, B. S., Kupper, L. L., Cassel, J. C., & Efird, R. L.Medication use and misuse: Physician-patient discrepancies. Journal of Chronic Diseases, 1975, 28, 7–21.CrossRefGoogle ScholarPubMed
57. Iowa Medicaid OPDUR Demonstration Project Report, 06 1994, unpublished.Google Scholar
58.Irwin, D. S., Weitzell, W. D., & Morgan, D. W.Phenothiazine intake and staff attitudes. American Journal of Psychiatry, 1971, 127, 1631–35.CrossRefGoogle ScholarPubMed
59.Johannesson, M.The costs of treating hypertension. International Journal of Technology Assessment in Health Care, 1992, 8, 507–23.Google Scholar
60.Jones, J. K.Assessing potential risk of drugs: The elusive target. Annals of Internal Medicine, 1992, 117, 691–92.CrossRefGoogle ScholarPubMed
61.Kane, R.L., Solomon, D.H., Beck, J. C., et al. Geriatrics in the United States: Manpower projections and training considerations. Lexington, MA: Lexington Books, 1981.Google Scholar
62.Klein, L. E., German, P. S., McPhee, S. J., & Levine, D. M.Aging and its relationship to health knowledge and medication compliance. Gerontologist, 1982, 22, 384–87.CrossRefGoogle ScholarPubMed
63.Korsch, B., & Negrete, V.Doctor-patient communication. Scientific American, 1972, 227, 66–74.CrossRefGoogle ScholarPubMed
64.Kotler, P., & Roberto, E.Social marketing: Strategies for changing public behavior. New York: Free Press, 1989.Google Scholar
65.Kunin, C. M.Resistance to antimicrobial drugs — a worldwide calamity. Annals of Internal Medicine, 1993, 118, 557–61.CrossRefGoogle ScholarPubMed
66.Kupst, M. J., Dresser, K., Shulman, J. L., & Paul, M. H.Evaluation of theory and methods to improve communication in the physician-patient relationship. American Journal of Orthopsychiatry, 1975, 45, 420–29.CrossRefGoogle Scholar
67.Ley, P.Memory for medical information. British Journal of Social and Clinical Psychology, 1979, 18, 245–52.CrossRefGoogle ScholarPubMed
68.Lipton, H. L., Bero, L. A., Bird, J. A., & McPhee, S. J.The impact of clinical pharmacists' consultations on physicians' geriatric drug prescribing: A randomized controlled trial. Medical Care, 1992, 30, 646–58.CrossRefGoogle ScholarPubMed
69.Lipton, H. L., & Bird, J. A.The impactof clinical pharmacists' consultations on geriatric patients' compliance and medical care use: A randomized controlled trial. Gerontologist, 1994, 34, 307–15.CrossRefGoogle Scholar
70.Lipton, H. L., & Lee, P. R.Drugs and the elderly: Clinical, social and policy perspectives Stanford, CA: Stanford University Press, 1988.Google Scholar
71.Lobas, N. H., Lepinski, P. W., & Abramowitz, P. W.Effects of pharmaceutical care on medication cost and quality of patient care in an ambulatory care clinic. American Journal of Hospital Pharmacy, 1992, 49, 1681–88.Google Scholar
72.Long, H. B.Adult learning: Research and practice. New York: Cambridge University Press, 1983.Google Scholar
73.Lundin, D. V., Eros, P. A., Melloh, J., & Sands, J. E.Education of independent elderly in the responsible use of prescription medications. Drug Intelligence and Clinical Pharmacy, 1980, 14, 335–42.CrossRefGoogle ScholarPubMed
74.Manasse, H. R. Jr., Medication use in an imperfect world: Drug misadventuring as an issue of public policy, part 1.American Journal of Hospital Pharmacy, 1989, 46, 1141–52.Google Scholar
75.Manasse, H. R. Jr., Medication use in an imperfect world: Drug misadventuring as an issue of public policy, part 2. American Journal of Hospital Pharmacy, 1989, 46, 929–44.Google Scholar
76.Maronde, R. F., Chen, L. S., Larsen, F. J., et al. Underutilization of antihypertensive drugs and associated hospitalization. Medical Care, 1989, 27, 1159–66.CrossRefGoogle ScholarPubMed
77.Matchar, D. B., Huesgen, C. T., Moore, W. S., et al. Indications for carotid endarterectomy: A comparison of ratings by a multidisciplinary expert panel with recommendations from the Joint Council of the Society for Vascular Surgery/International Society for Cardiovascular Surgery (North American Chapter). Unpublished, 1992, 1–26.Google Scholar
78.McGuire, W. Persuasion, resistance and attitude change. In De Sola Pool, I., Frey, F. W., Schramm, W., Maccoby, N., & Parker, E. B. (eds.), Handbook of Communication. Chicago: Rand McNally, 1973, 216–62.Google Scholar
79.McKenney, J. M., Brown, E. D., Necsary, R., & Reavis, H. L.Effect of pharmacist drug monitoring and patient education on hypertensive patients. Contemporary Pharmacy Practice, 1978, 1, 50–56.Google Scholar
80.McKenney, J. M., Slining, J. M., Henderson, H. R., et al. The effect of clinical pharmacy services on patients with essential hypertension. Circulation, 1973, 48, 1104–11.CrossRefGoogle ScholarPubMed
81.Miller, S. W., Marshall, L. L., & Preston, M. S.Impact of pharmacist-conducted drug-regimen review on drug use in an intermediate-care facility. Consultant Pharmacist, 1992, 39, 1907–10.Google Scholar
82.Monane, M., Bohn, R. L., Gurwitz, J. H., Glynn, R. J., & Avorn, J.Noncompliance with congestive heart failure therapy in the elderly. Archives of Internal Medicine, 1994, 154, 433–37.CrossRefGoogle ScholarPubMed
83.Monson, R., Bond, C. A., & Schuna, A.Role of the clinical pharmacist in improving drug therapy. Archives of Internal Medicine, 1981, 141, 1441–44.CrossRefGoogle ScholarPubMed
84.Moore, W. S.Carotid endarterectomy for prevention of stroke. Western Journal of Medicine, 1993, 159, 37–43.Google ScholarPubMed
85.Mulrow, C., Bailey, S., Sonksen, P. H., & Slavin, B.Evaluation of an audiovisual diabetes education program: Negative results of a randomized trial of patients with non-insulin-dependent diabetes mellitus. Journal of General Internal Medicine, 1987, 2, 215–19.CrossRefGoogle ScholarPubMed
86.Omnibus Budget Reconciliation Act, 1990. Section 1927 GH of the Social Security Act (Public Law 101508), Washington, DC.Google Scholar
87.Ostrom, J. R., Hammarlund, E. R., Christensen, D. B., et al. Medication usage in an elderly population. Medical Care, 1985, 23, 157–64.CrossRefGoogle Scholar
88.Raisch, D. W., Bootman, J. L., Larson, L. N., & McGhan, W. F.Improving antiulcer agent prescribing in a health maintenance organization. American Journal of Hospital Pharmacy, 1990, 47, 1766–73.Google Scholar
89.Raven, B. H. The comparative analyses of power and influence. In Tedeschi, J. T. (ed.), Perspectives in Social Power. Chicago: Adline, 1974.Google Scholar
90.Ray, W., & Griffin, M. R.Pharmaceutical effectiveness research: Meeting information needs of clinical and policy decision-making. Presented at the Pharmaceutical Outcomes Research meeting, December 12–13, 1991, Bethesda, MD. Sponsored by the Agency for Health Care Policy and Research, 1991.Google Scholar
91.Ray, W. A., Griffin, M. R., & Avorn, J.Evaluating drugs after their approval for clinical use. New England Journal of Medicine, 1993, 329, 2029–32.CrossRefGoogle ScholarPubMed
92.Ray, W. A., Griffin, M. R., & Downey, W.Benzodiazepines of long and short elimination half-life and the risk of hip fracture. Journal of the American Medical Association, 1989, 262, 3303–07.CrossRefGoogle ScholarPubMed
93.Ray, W. A., Griffin, M. R., Schaffner, W., et al. Psychotropic drug use and the risk of hip fracture. New England Journal of Medicine, 1987, 316, 363–69.CrossRefGoogle ScholarPubMed
94.Ray, W. A., Schaffner, W., & Oates, J. A.Therapeutic choice in the treatment of hypertension: Initial treatment of newly diagnosed hypertension and secular trends in the prescribing of antihypertensive medications for Medicaid patients. American Journal of Medicine, 1:386, 81, 9–16.CrossRefGoogle Scholar
95.Rice, D. P., & Estes, C. L.Health of the elderly: Policy issues and challenges. Health Affairs, 1984, 3, 25–49.CrossRefGoogle ScholarPubMed
96.Rogers, E.Diffusion of Innovations. New York: Free Press, 1983.Google Scholar
97.Rogers, E. M., & Kincaid, D. L.Communication networks: Toward a new paradigm for research. New York: Free Press, 1981.Google Scholar
98.Ross-Degnan, D., Soumerai, S. B., Fortess, E. E., & Gurwitz, J. H.Examining product risk in context: Market withdrawal of zomepirac as a case study. Journal of the American Medical Association, 1993, 270, 1937–42.CrossRefGoogle ScholarPubMed
99.Rovelli, M., Palmeri, D., Vossler, E., et al. Noncompliance in organ transplant recipients. Transplant Proceedings, 1989, 21, 833–34.Google ScholarPubMed
100.Rucker, T. D.Pursuing rational drug therapy: A macro view a la the USA. Journal of Social Administrative Pharmacy, 1988, 5, 78–86.Google Scholar
101.Rucker, T. D., & Schiff, G.Drug formularies: Myths-in-formation. Medical Care, 1990, 28, 928–42.CrossRefGoogle ScholarPubMed
102.Rupp, M. T.Value of community pharmacists' interventions to correct prescribing errors. Annals of Pharmacolherapy, 1992, 26, 1580–84.CrossRefGoogle ScholarPubMed
103.Rupp, M. T., DeYoung, M., & Schondelmeyer, S. W.Prescribing problems and pharmacist interventions in community practice. Medical Care, 1992, 30, 926–40.CrossRefGoogle ScholarPubMed
104.Schaffner, W., Ray, W. A., Federspiel, C. F., & Muller, W. O.Improving antibiotic prescribing in office practice: A controlled trial of three educational methods. Journal of the American Medical Association, 1983, 250, 1728–32.CrossRefGoogle Scholar
105.Schwartz, D., Wang, M., Zeitz, L., & Goss, M. E. W.Medication errors made by the elderly, chronically ill patients. American Journal of Public Health, 1962, 52, 2018–29.CrossRefGoogle ScholarPubMed
106.Schwartz, R. K., Soumerai, S. B., & Avorn, J.Physician motivations for nonscientific drug prescribing. Social Science and Medicine, 1989, 28, 577–82.CrossRefGoogle ScholarPubMed
107.Sclar, D. A., Skaer, T. L., Chin, A., et al. Effect of health education on the utilization of HMO services: A prospective trial among patients with hypertension. Primary Cardiology, 1992, 1, 30–35.Google Scholar
108.Scrivens, J. J., Magalian, P., & Crozier, G. A.Cost-effective clinical pharmacy services in a Veterans Administration drop-in clinic. American Journal of Hospital Pharmacy, 1983, 40, 1952–53.Google Scholar
109.Sidel, V. W., Belzer, J. L., Lisi-Fazio, D., et al. Controlled study of the impact of educational home visits by pharmacists to high-risk older patients. Journal of Community Health, 1990, 15, 163–74.CrossRefGoogle ScholarPubMed
110.Smith, P. J., & Byrns, P. J.Prospective DUR: Is it Needed or Useful? Colorado Medicaid State Board of Pharmacy Task Force, 10, 1992, mimeographed.Google Scholar
111.Sorock, G. S., & Shimkin, E. E.Benzodiazepine sedatives and the risk of falling in a community-dwelling elderly cohort. Archives of Internal Medicine, 1988, 148, 2441–44.CrossRefGoogle Scholar
112.Soumerai, S. B., & Avorn, J.Economic and policy analysis of university-based drug ‘detailing.’ Medical Care, 1986, 24, 313–31.CrossRefGoogle ScholarPubMed
113.Soumerai, S. B., & Avorn, J.Efficacy and cost-containment in hospital pharmacotherapy: State of the art and future directions. Milbank Memorial Fund Quarterly, 1984, 62, 447–74.CrossRefGoogle ScholarPubMed
114.Soumerai, S. B., & Avorn, J.Predictors of physician prescribing change in an educational experiment to improve medication use. Medical Care, 1987, 25, 210–21.CrossRefGoogle Scholar
115.Soumerai, S. B., & Avorn, J.Principles of educational outreach (academic detailing) to improve clinical decision making. Journal of the American Medical Association, 1990, 263, 549–56.CrossRefGoogle ScholarPubMed
116.Soumerai, S. B., Avorn, J., Gortmaker, S., & Hawley, S.Effect of government and commercial warnings on reducing prescription misuse: The case of propoxyphene. American Journal of Public Health, 1987, 77, 1518–23.CrossRefGoogle ScholarPubMed
117.Soumerai, S. B., Avorn, J., Ross-Degnan, D., & Gortmaker, S.Payment restrictions for prescription drugs in Medicaid: Effects on therapy, cost, and equity. New England Journal of Medicine, 1987, 317, 550–56.CrossRefGoogle Scholar
118.Soumerai, S. B., & Lipton, H. L. Evaluating and improving physician prescribing. In Strom, B. L. (ed.), Pharmacoepidemiology, 2nd ed. New York: John Wiley & Sons, 1994.Google Scholar
119.Soumerai, S. B., McLaughlin, T. J., & Avorn, J.Improving drug prescribing in primary care: A critical analysis of the experimental literature. Milbank Quarterly, 1989, 67, 268–317.CrossRefGoogle ScholarPubMed
120.Soumerai, S. B., Ross-Degnan, D., Avorn, J., et al. Effects of Medicaid drug-payment limits on admission to hospitals and nursing homes. New England Journal of Medicine, 1991, 325, 1072–77.CrossRefGoogle ScholarPubMed
121.Soumerai, S. B., Ross-Degnan, D., Fortess, E. E., & Abelson, J.A critical analysis of studies of state drug reimbursement policies: Research in need of discipline. Milbank Quarterly, 1993, 71, 217–52.CrossRefGoogle ScholarPubMed
122.Spaulding, G., & Campbell, R. K.Paying the pharmacist a fee for detecting adverse drug reactions. Journal of American Pharmaceutical Association, 1976, 16, 86–89.Google ScholarPubMed
123.Stergachis, A. M., Fors, E. H., Wagner, D. D., et al. Effect of clinical pharmacists on drug prescribing in a primary-care clinic. American Journal of Hospital Pharmacy, 1987, 44, 525–28.Google Scholar
124.Stolar, M. H.Drug use review: Operational definitions. American Journal of Hospital Pharmacy, 1978, 35, 76–78.Google ScholarPubMed
125.Strand, L. M., Morley, P. C., Cipolle, R. J., et al. Drug-related problems: Their structure and function. DICP Annals of Pharmacotherapy, 1990, 24, 1093–97.Google ScholarPubMed
126.Sullivan, S. D., Kreling, D. H., & Hazlet, T. K.Noncompliance with medication regimens and subsequent hospitalizations: A literature analysis and cost of hospitalization estimate. Journal of Research in Pharmaceutical Economics, 1990, 2, 19–33.Google Scholar
127.Svarstad, B. L. Patient-practitioner relationships and compliance with prescribed medical regimens. In Aiken, L. & Mechanic, D. (eds.), Application of social science to clinical medicine and health policy. New Brunswick: Rutgers University Press, 1986, 438–59.Google Scholar
128.Svarstad, B. L. Physician-patient communication and patient conformity with medical advice. In Mechanic, D. (ed.), The growth bureaucratic medicine: An inquiry into the dynamics of patient behavior and the organization of medical care. New York: Wiley, 1976, 220–38.Google Scholar
129.Tinetti, M. E., Speechley, M., & Ginter, S. F.Risk factors for falls among elderly persons living in the community. New England Journal of Medicine, 1988, 319, 1701–07.CrossRefGoogle ScholarPubMed
130.U.S. Department of Health and Human Services. Medicaid drug use review demonstration projects: Report to Congress. Baltimore, MD: U.S. Department of Health and Human Services, HCFA Pub. No. 03356, 06 1994.Google Scholar
131.Vinson, J. M., Rich, M. W., Sperry, J. C., et al. Early readmission of elderly patients with congestive heart failure. Journal of the American Geriatrics Society, 1990, 38, 1290–95.CrossRefGoogle ScholarPubMed
132.Wade, O. L., & Hood, H.Prescribing of drugs reported to cause adverse reactions. British Journal of Preventive Social Medicine, 1972, 26, 205–11.Google ScholarPubMed
133.Weintraub, M. Intelligent noncompliance and capricious compliance. In Lasagna, L. (ed.), Patient compliance, vol. 10. Mt. Kisco: Futura, 1976, 39–47.Google Scholar
134.Weintraub, M., Au, W., & Lasagna, L.Compliance as a determinant of serum digoxin concentration. Journal of the American Medical Association, 1973, 224, 481–85.CrossRefGoogle ScholarPubMed
135.Wheeler, L. A., Wheeler, M. L., Ours, P., & Swider, C.Evaluation of computer-based diet education in persons with diabetes mellitus and limited educational background. Diabetes Care, 1985, 8, 537–44.CrossRefGoogle ScholarPubMed
136.Wilcox, S. M., Himmelstein, D. U., & Woolhandler, S.Inappropriate drug prescribing for the community-dwelling elderly. Journal of the American Medical Association, 1994, 272, 292–96.CrossRefGoogle Scholar
137.Winslow, C. M., Solomon, D. H., Chassin, M. R., et al. The appropriateness of carotid endarterectomy. New England Journal of Medicine, 1988, 318, 721–27.CrossRefGoogle ScholarPubMed
138.Wong, D.G., Lamki, L., Spence, J. D., et al. Effect of NSAID on control of hypertension by beta-blockers and diuretics. Lancet, 1986, 1, 997–1001.CrossRefGoogle ScholarPubMed