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Altered intrinsic default mode network functional connectivity in patients with remitted geriatric depression and amnestic mild cognitive impairment

Published online by Cambridge University Press:  12 October 2021

Chengbin Guan Open the ORCID record for Chengbin Guan [Opens in a new window] ,
Nousayhah Amdanee ,
Wenxiang Liao ,
Chao Zhou ,
Xin Wu ,
Xiangrong Zhang  and
Caiyi Zhang
Chengbin Guan
Affiliation:
Department of Geriatric Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, Jiangsu, China
Nousayhah Amdanee
Affiliation:
Department of Geriatric Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, Jiangsu, China
Wenxiang Liao
Affiliation:
Department of Neurology, Laboratory of Neuroscience, The Affiliated Hospital of Guilin Medical University, Guilin, Guangxi, China
Chao Zhou
Affiliation:
Department of Geriatric Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, Jiangsu, China
Xin Wu
Affiliation:
Department of Geriatric Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, Jiangsu, China
Xiangrong Zhang*
Affiliation:
Department of Geriatric Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, Jiangsu, China
Caiyi Zhang*
Affiliation:
The Affiliated Xuzhou Oriental Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China
*
Correspondence should be addressed to: Xiangrong Zhang, Department of Geriatric Psychiatry, the Affiliated Brain Hospital of Nanjing Medical University, No.264, Guangzhou Road, Gulou District, Nanjing, Jiangsu, 210029, China. Tel: +86-25-82296586.  Email: drxrz@hotmail.com; Caiyi Zhang, The Affiliated Xuzhou Oriental Hospital of Xuzhou Medical University,No. 379, Tongshan Road, Yunlong District, Xuzhou, Jiangsu, 221004, China. Tel: +8613775889105. Email: amanzcy@live.cn
Correspondence should be addressed to: Xiangrong Zhang, Department of Geriatric Psychiatry, the Affiliated Brain Hospital of Nanjing Medical University, No.264, Guangzhou Road, Gulou District, Nanjing, Jiangsu, 210029, China. Tel: +86-25-82296586.  Email: drxrz@hotmail.com; Caiyi Zhang, The Affiliated Xuzhou Oriental Hospital of Xuzhou Medical University,No. 379, Tongshan Road, Yunlong District, Xuzhou, Jiangsu, 221004, China. Tel: +8613775889105. Email: amanzcy@live.cn
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Abstract

Objectives:

Patients with geriatric depression exhibit a spectrum of symptoms ranging from mild to severe cognitive impairment which could potentially lead to the development of Alzheimer’s disease (AD). The aim of the study is to assess the alterations of the default mode network (DMN) in remitted geriatric depression (RGD) patients and whether it could serve as an underlying neuropathological mechanism associated with the risk of progression of AD.

Design:

Cross-sectional study.

Participants:

A total of 154 participants, comprising 66 RGD subjects (which included 27 patients with comorbid amnestic mild cognitive impairment [aMCI] and 39 without aMCI [RGD]), 45 aMCI subjects without a history of depression (aMCI), and 43 matched healthy comparisons (HC), were recruited.

Measurements:

All participants completed neuropsychological tests and underwent resting-state functional magnetic resonance imaging (fMRI). Posterior cingulate cortex (PCC)-seeded DMN functional connectivity (FC) along with cognitive function were compared among the four groups, and correlation analyses were conducted.

Results:

In contrast to HC, RGD, aMCI, and RGD-aMCI subjects showed significant impairment across all domains of cognitive functions except for attention. Furthermore, compared with HC, there was a similar and significant decrease in PCC-seed FC in the bilateral medial superior frontal gyrus (M-SFG) in the RGD, aMCI, and RGD-aMCI groups.

Conclusions:

The aberrations in rsFC of the DMN were associated with cognitive deficits in RGD patients and might potentially reflect an underlying neuropathological mechanism for the increased risk of developing AD. Therefore, altered connectivity in the DMN could serve as a potential neural marker for the conversion of geriatric depression to AD.

Keywords

amnestic mild cognitive impairment (aMCI)bilateral medial superior frontal gyrus (M-SFG)default mode network (DMN)functional connectivity (FC)remitted geriatric depression (RGD)
Type
Original Research Article
Information
International Psychogeriatrics , Volume 34 , Special Issue 8: Issue Theme: Geriatric Mental Health among Chinese Older Adults , August 2022 , pp. 703 - 714
Copyright
© International Psychogeriatric Association 2021

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Footnotes

†

Chengbin Guan, Nousayhah Amdanee and Wenxiang Liao contributed equally to this work.

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