Hostname: page-component-cd9895bd7-8ctnn Total loading time: 0 Render date: 2024-12-27T13:31:36.755Z Has data issue: false hasContentIssue false
  • English
  • Français

Cardiovascular diseases and related risk factors accelerated cognitive deterioration in patients with late-life depression: a one-year prospective study

Published online by Cambridge University Press:  30 January 2019

Xiaomei Zhong ,
Zhangying Wu ,
Cong Ouyang ,
Wanyuan Liang ,
Ben Chen ,
Qi Peng ,
Naikeng Mai ,
Yuejie Wu ,
Xinru Chen  and
Min Zhang
...Show all authors
Xiaomei Zhong
Affiliation:
Department of Psychiatry, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, China
Zhangying Wu
Affiliation:
Department of Psychiatry, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, China
Cong Ouyang
Affiliation:
Department of Psychiatry, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, China
Wanyuan Liang
Affiliation:
Department of Psychiatry, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, China
Ben Chen
Affiliation:
Department of Psychiatry, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, China
Qi Peng
Affiliation:
Department of Psychiatry, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, China
Naikeng Mai
Affiliation:
Department of Neurology, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, China
Yuejie Wu
Affiliation:
Department of Psychiatry, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, China
Xinru Chen
Affiliation:
Department of Psychiatry, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, China
Min Zhang
Affiliation:
Department of Neurology, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, China
Yuping Ning*
Affiliation:
Department of Psychiatry, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, China Department of Neurology, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, China
*
Correspondence should be addressed to: Yuping Ning, Administration Building, Guangzhou Huiai Hospital, Mingxin Road, Liwan District, Guangzhou, Guangdong, China. Phone: +8620-8126-8720; Fax: +8620-8189-1391. Email: ningjeny@126.com.
Get access

Abstract

Objectives:

Cognitive impairment in late-life depression is common and associated with a higher risk of all-cause dementia. Late-life depression patients with comorbid cardiovascular diseases (CVDs) or related risk factors may experience higher risks of cognitive deterioration in the short term. We aim to investigate the effect of CVDs and their related risk factors on the cognitive function of patients with late-life depression.

Methods:

A total of 148 participants were recruited (67 individuals with late-life depression and 81 normal controls). The presence of hypertension, coronary heart disease, diabetes mellitus, or hyperlipidemia was defined as the presence of comorbid CVDs or related risk factors. Global cognitive functions were assessed at baseline and after a one-year follow-up by the Mini-Mental State Examination (MMSE). Global cognitive deterioration was defined by the reliable change index (RCI) of the MMSE.

Results:

Late-life depression patients with CVDs or related risk factors were associated with 6.8 times higher risk of global cognitive deterioration than those without any of these comorbidities at a one-year follow-up. This result remained robust after adjusting for age, gender, and changes in the Hamilton Depression Rating Scale (HAMD) scores.

Conclusions:

This study suggests that late-life depression patients with comorbid CVDs or their related risk factors showed a higher risk of cognitive deterioration in the short-term (one-year follow up). Given that CVDs and their related risk factors are currently modifiable, active treatment of these comorbidities may delay rapid cognitive deterioration in patients with late-life depression.

Keywords

depressioncognitive impairmentrisk factors
Type
Original Research Article
Information
International Psychogeriatrics , Volume 31 , Issue 10: Issue Theme: Dementia and the Society , October 2019 , pp. 1483 - 1489
Copyright
© International Psychogeriatric Association 2019 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Baumgart, M., Snyder, H. M., Carrillo, M. C., Fazio, S., Kim, H. and Johns, H. (2015). Summary of the evidence on modifiable risk factors for cognitive decline and dementia: a population-based perspective. Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association, 11, 718–726.CrossRefGoogle ScholarPubMed
Bhalla, R. K. et al. (2006). Persistence of neuropsychologic deficits in the remitted state of late-life depression. The American Journal of Geriatric Psychiatry: Official Journal of the American Association for Geriatric Psychiatry, 14, 419–427.CrossRefGoogle ScholarPubMed
Biessels, G. J., Staekenborg, S., Brunner, E., Brayne, C. and Scheltens, P. (2006). Risk of dementia in diabetes mellitus: a systematic review. The Lancet. Neurology, 5, 64–74.CrossRefGoogle ScholarPubMed
Briggs, R., Tobin, K., Kenny, R. A. and Kennelly, S. P. (2018). What is the prevalence of untreated depression and death ideation in older people? Data from the Irish Longitudinal Study on Aging. International Psychogeriatrics, 30, 1393–1401.CrossRefGoogle ScholarPubMed
Bruce, M. L. et al. (2004). Reducing suicidal ideation and depressive symptoms in depressed older primary care patients: a randomized controlled trial. JAMA, 291, 1081–1091.CrossRefGoogle ScholarPubMed
Byers, A. L. and Yaffe, K. (2011). Depression and risk of developing dementia. Nature Reviews. Neurology, 7, 323–331.CrossRefGoogle ScholarPubMed
Chang, Y. H. et al. (2013). Cognitive performance in older elderly men with late-life depression and cardiovascular comorbidities: symptomatological correlation. Annals of General Psychiatry, 12, 36.CrossRefGoogle ScholarPubMed
Charlson, M. and Peterson, J. C. (2002). Medical comorbidity and late life depression: what is known and what are the unmet needs? Biological Psychiatry, 52, 226–235.CrossRefGoogle ScholarPubMed
Choi, N. G., Kim, J., Marti, C. N. and Chen, G. J. (2014). Late-life depression and cardiovascular disease burden: examination of reciprocal relationship. The American Journal of Geriatric Psychiatry: Official Journal of the American Association for Geriatric Psychiatry, 22, 1522–1529.CrossRefGoogle ScholarPubMed
de Bruijn, R. F. and Ikram, M. A. (2014). Cardiovascular risk factors and future risk of Alzheimer’s disease. BMC Medicine, 12, 130.CrossRefGoogle ScholarPubMed
den Heijer, T. et al. (2005). Association between blood pressure, white matter lesions, and atrophy of the medial temporal lobe. Neurology, 64, 263–267.CrossRefGoogle ScholarPubMed
Dias, F. et al. (2017). Cognitive performance of community-dwelling oldest-old individuals with major depression: the Pieta study. International Psychogeriatrics, 29, 1507–1513.CrossRefGoogle ScholarPubMed
Diniz, B. S., Butters, M. A., Albert, S. M., Dew, M. A. and Reynolds, C. F. (2013). Late-life depression and risk of vascular dementia and Alzheimer’s disease: systematic review and meta-analysis of community-based cohort studies. The British Journal of Psychiatry: The Journal of Mental Science, 202, 329–335.CrossRefGoogle ScholarPubMed
González, H. M. and Tarraf, W. (2013). Comorbid cardiovascular disease and major depression among ethnic and racial groups in the United States. International Psychogeriatrics, 25, 833–841.CrossRefGoogle ScholarPubMed
Hsu, L. M. (1999). Caveats concerning comparisons of change rates obtained with five methods of identifying significant client changes: comment on Speer and Greenbaum (1995). Journal of Consulting and Clinical Psychology, 67, 594–598.CrossRefGoogle Scholar
Izquierdo-Porrera, A. M. and Waldstein, S. R. (2002). Cardiovascular risk factors and cognitive function in African Americans. The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences, 57, P377–P380.CrossRefGoogle ScholarPubMed
Katon, W. et al. (2015). Effect of depression and diabetes mellitus on the risk for dementia: a national population-based cohort study. JAMA Psychiatry, 72, 612–619.CrossRefGoogle ScholarPubMed
Kaup, A. R. et al. (2016). Trajectories of depressive symptoms in older adults and risk of dementia. JAMA Psychiatry, 73, 525–531.CrossRefGoogle Scholar
Köhler, S., Thomas, A. J., Barnett, N. A. and O’Brien, J. T. (2010). The pattern and course of cognitive impairment in late-life depression. Psychological Medicine, 40, 591–602.CrossRefGoogle ScholarPubMed
Mirza, S. S. et al. (2014). Depressive symptoms predict incident dementia during short- but not long-term follow-up period. Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association, 10, S323–S329.e321.CrossRefGoogle Scholar
Mirza, S. S. et al. (2016). 10-year trajectories of depressive symptoms and risk of dementia: a population-based study. The Lancet. Psychiatry, 3, 628–635.CrossRefGoogle ScholarPubMed
Pugh, K. G., Kiely, D. K., Milberg, W. P. and Lipsitz, L. A. (2003). Selective impairment of frontal-executive cognitive function in african americans with cardiovascular risk factors. Journal of the American Geriatrics Society, 51, 1439–1444.CrossRefGoogle ScholarPubMed
Rapp, M. A., Dahlman, K., Sano, M., Grossman, H. T., Haroutunian, V. and Gorman, J. M. (2005). Neuropsychological differences between late-onset and recurrent geriatric major depression. The American Journal of Psychiatry, 162, 691–698.CrossRefGoogle ScholarPubMed
Reynolds, C. F. et al. (2011). Maintenance treatment of depression in old age: a randomized, double-blind, placebo-controlled evaluation of the efficacy and safety of donepezil combined with antidepressant pharmacotherapy. Archives of General Psychiatry, 68, 51–60.CrossRefGoogle ScholarPubMed
Richard, E. et al. (2013). Late-life depression, mild cognitive impairment, and dementia. JAMA Neurology, 70, 374–382.CrossRefGoogle Scholar
Schmidt, R. et al. (2004). Magnetic resonance imaging of the brain in diabetes: the Cardiovascular Determinants of Dementia (CASCADE) Study. Diabetes, 53, 687–692.CrossRefGoogle ScholarPubMed
Schneider, B., Ercoli, L., Siddarth, P. and Lavretsky, H. (2012). Vascular burden and cognitive functioning in depressed older adults. The American Journal of Geriatric Psychiatry, 20, 673–681.CrossRefGoogle ScholarPubMed
Sheffrin, M. et al. (2009). Pilot study of augmentation with aripiprazole for incomplete response in late-life depression: getting to remission. The Journal of Clinical Psychiatry, 70, 208–213.CrossRefGoogle Scholar
Sheline, Y. I. et al. (2006). Cognitive function in late life depression: relationships to depression severity, cerebrovascular risk factors and processing speed. Biological Psychiatry, 60, 58–65.CrossRefGoogle ScholarPubMed
Sheline, Y. I. et al. (2010). Support for the vascular depression hypothesis in late-life depression: results of a 2-site, prospective, antidepressant treatment trial. Archives of General Psychiatry, 67, 277–285.CrossRefGoogle ScholarPubMed
Sims, R., Madhere, S., Callender, C. and Campbell, A. (2008). Patterns of relationships between cardiovascular disease risk factors and neurocognitive function in African Americans. Ethnicity & Disease, 18, 471–476.Google ScholarPubMed
Steffens, D. C. (2017). Late-life depression and the prodromes of dementia. JAMA Psychiatry, 74, 673–674.CrossRefGoogle Scholar
Steffens, D. C., Snowden, M., Fan, M. Y., Hendrie, H., Katon, W. J. and Unützer, J. (2006). Cognitive impairment and depression outcomes in the IMPACT study. The American Journal of Geriatric Psychiatry: Official Journal of the American Association for Geriatric Psychiatry, 14, 401–409.CrossRefGoogle ScholarPubMed
Taylor, W. D., McQuoid, D. R. and Krishnan, K. R. (2004). Medical comorbidity in late-life depression. International Journal of Geriatric Psychiatry, 19, 935–943.CrossRefGoogle ScholarPubMed
Whitmer, R. A., Sidney, S., Selby, J., Johnston, S. C. and Yaffe, K. (2005). Midlife cardiovascular risk factors and risk of dementia in late life. Neurology, 64, 277–281.CrossRefGoogle ScholarPubMed
Zuidersma, M., Izaks, G. J., Naarding, P., Comijs, H. C. and Oude Voshaar, R. C. (2015). Vascular burden and cognitive function in late-life depression. The American Journal of Geriatric Psychiatry, 23, 514–524.CrossRefGoogle ScholarPubMed