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Clinical Global Impressions in Alzheimer's Clinical Trials

Published online by Cambridge University Press:  07 January 2005

Lon S. Schneider  and
Jason T. Olin
Lon S. Schneider
Affiliation:
Department of Psychiatry and Behavioral Sciences,University of Southern California, Los Angeles, California, U.S.A. Department of Neurology, School of Medicine, University of Southern California, Los Angeles, California, U.S.A. School of Gerontology, University of Southern California, Los Angeles, California, U.S.A.
Jason T. Olin
Affiliation:
Department of Psychiatry and Behavioral Sciences,University of Southern California, Los Angeles, California, U.S.A.
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Abstract

This article reviews the history of Clinical Global Impressions of Change (CGIC) instruments, their use and limitations in clinical trials of Alzheimer's disease, and the development of the National Institute on Aging's Alzheimer's Disease Cooperative Study-Clinical Global Impression of Change Scale (ADCS-CGIC). Originally, CGICs were simple and unstructured instruments that asked a clinician to rate change over the duration of a clinical trial. The method, however, failed to consistently detect treatment effects, leading to the development of more structured and subsequently validated approaches, such as the Clinician Interview-Based Impression Scale (CIBI) and the ADCS-CGIC. Both are currently used in clinical trials. The implications and importance of choosing an appropriate global rating are discussed.

Type
Clinical Global Impression of Change
Information
International Psychogeriatrics , Volume 8 , Issue 2 , June 1996 , pp. 277 - 290
Copyright
© 1996 International Psychogeriatric Association

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