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Dementia clinical trial implications of mild behavioral impairment

Published online by Cambridge University Press:  16 February 2018

Moyra E. Mortby
Affiliation:
Centre for Research on Ageing, Health and Wellbeing, Research School of Population Health, The Australian National University, Canberra, Australia NHMRC National Institute for Dementia Research, Canberra, Australia
Sandra E. Black
Affiliation:
Department of Medicine (Neurology), Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute, Sunnybrook HSC, University of Toronto, Toronto, Canada
Serge Gauthier
Affiliation:
McGill Center for Studies in Aging, Douglas Mental Health Research Institute, Montreal, Canada
David Miller
Affiliation:
Bracket Global, Wayne, Pennsylvania, USA
Anton Porsteinsson
Affiliation:
Alzheimer's Disease Care, Research and Education Program (AD-CARE), University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
Eric E. Smith
Affiliation:
Department of Clinical Neurosciences, Ron and Rene Ward Centre for Healthy Brain Aging, Hotchkiss Brain Institute, University of Calgary, Calgary, Canada Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Canada
Zahinoor Ismail*
Affiliation:
Department of Clinical Neurosciences, Ron and Rene Ward Centre for Healthy Brain Aging, Hotchkiss Brain Institute, University of Calgary, Calgary, Canada Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Canada Department of Psychiatry, Mathison Centre for Mental Health Research & Education, University of Calgary, Calgary, Canada
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The World Alzheimer Report 2016 estimated that 47 million people are living with dementia worldwide (Alzheimer's Disease International, 2016). In the inaugural World Health Organization Ministerial Conference on Global Action against Dementia, six of the top ten research priorities were focused on prevention, identification, and reduction of dementia risk, and on delivery and quality of care for people with dementia and their carers (Shah et al., 2016). While the Lancet Neurology Commission has suggested that even minor advances to delay progression or ameliorate symptoms might have substantial financial and societal benefits (Winblad et al., 2016), advances have been slow.

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Commentary
Copyright
Copyright © International Psychogeriatric Association 2018 

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References

Almeida, O., Hankey, G., Yeap, B., Golledge, J. and Flicker, L. (2017). Depression as a modifiable factor to decrease the risk of dementia. Translational Psychiatry, 7, e1117.Google Scholar
Babulal, G. M. et al. (2016). Mood changes in cognitively normal older adults are linked to Alzheimer disease biomarker levels. The American Journal of Geriatric Psychiatry, 24, 10951104.Google Scholar
Banzi, R., Camaioni, P., Tettamanti, M. and Lucca, U. (2016). Older patients are still under-represented in clinical trials of Alzheimer's disease. Alzheimer's Research & Therapy, 8, 32.Google Scholar
Del Campo, N. et al. (2016). Relationship of regional brain β-amyloid to gait speed. Neurology, 86, 3643.Google Scholar
Desmarais, P., Lanctôt, K. L., Masellis, M., Black, S. E. and Herrmann, N. (2017). Social inappropriateness in neurodegenerative disorders. International Psychogeriatrics, 111. doi:10.1017/S1041610217001260 Google Scholar
Donovan, N. J. et al. (2014). Regional cortical thinning predicts worsening apathy and hallucinations across the Alzheimer disease spectrum. The American Journal of Geriatric Psychiatry, 22, 11681179.Google Scholar
Fargo, K. N., Carrillo, M. C., Weiner, M. W., Potter, W. Z. and Khachaturian, Z. (2016). The crisis in recruitment for clinical trials in Alzheimer's and dementia: an action plan for solutions. Alzheimer's & Dementia, 12, 11131115.Google Scholar
Fernández-Matarrubia, M., Matias-Guiu, J., Moreno-Ramos, T. and Matias-Guiu, J. (2015). Biomarkers: a new approach to behavioural variant frontotemporal dementia. Neurología (English Edition), 30, 5061.CrossRefGoogle ScholarPubMed
Fischer, C. E. and Agüera-Ortiz, L. (2017). Psychosis and dementia: risk factor, prodrome, or cause? International Psychogeriatrics, 111. doi:10.1017/S1041610217000874 Google Scholar
Gauthier, S. et al. (2016). Why has therapy development for dementia failed in the last two decades? Alzheimer's & Dementia, 12, 6064.Google Scholar
Graham, W. V., Bonito-Oliva, A. and Sakmar, T. P. (2017). Update on Alzheimer's disease therapy and prevention strategies. Annual Review of Medicine, 68, 413430.Google Scholar
Hellmuth, J. et al. (2012). Multicenter validation of a bedside antisaccade task as a measure of executive function. Neurology, 78, 18241831.Google Scholar
Alzheimer's Disease International (2016). World Alzheimer's report.Google Scholar
Ismail, Z. and Mortby, M. E. (2017). Cognitive and neuropsychiatric screening tests in older adults. In Chiu, H. and Shulman, K. (eds.), Mental Health and Illness of the Elderly. New Delhi: Springer.Google Scholar
Ismail, Z. et al. (2016). Neuropsychiatric symptoms as early manifestations of emergent dementia: provisional diagnostic criteria for mild behavioral impairment. Alzheimer's & Dementia, 12, 195202.Google Scholar
Ismail, Z. et al. (2017a). The mild behavioral impairment checklist (MBI-C): a rating scale for neuropsychiatric symptoms in pre-dementia populations. Journal of Alzheimer's Disease, 56, 929938.Google Scholar
Ismail, Z. et al. (2017b). Affective and emotional dysregulation as pre-dementia risk markers: exploring the mild behavioral impairment symptoms of depression, anxiety, irritability, and euphoria. International Psychogeriatrics, 112. doi:10.1017/S1041610217001880 Google Scholar
Jalal, H., Ganesh, A., Lau, R., Lysack, J. and Ismail, Z. (2014). Cholinesterase-inhibitor associated mania: a case report and literature review. The Canadian Journal of Neurological Sciences, 41, 278280.CrossRefGoogle Scholar
Kwan-Chun Ting, W., Fischer, C. E., Millikin, C. P., Ismail, Z., Chow, T. W. and Schweizer, T. A. (2015). Grey matter atrophy in mild cognitive impairment/early Alzheimer disease associated with delusions: a voxel-based morphometry study. Current Alzheimer Research, 12, 165172.Google Scholar
Ladas, A., Frantzidis, C., Bamidis, P. and Vivas, A. B. (2014). Eye blink rate as a biological marker of mild cognitive impairment. International Journal of Psychophysiology, 93, 1216.CrossRefGoogle ScholarPubMed
Lanctôt, K. L. et al. (2016). Apathy associated with neurocognitive disorders: recent progress and future directions. Alzheimer's & Dementia.Google Scholar
Lin, F. R., Metter, E. J., O'Brien, R. J., Resnick, S. M., Zonderman, A. B. and Ferrucci, L. (2011). Hearing loss and incident dementia. Archives of Neurology, 68, 214220.CrossRefGoogle ScholarPubMed
Mortby, M. E. and Anstey, K. J. (2015). Mental health and aging. In Pachana, A. N. (ed.), Encyclopedia of Geropsychology (pp. 16). Singapore: Springer Singapore.Google Scholar
Nagata, T., Kobayashi, N., Shinagawa, S., Yamada, H., Kondo, K. and Nakayama, K. (2014). Plasma BDNF levels are correlated with aggressiveness in patients with amnestic mild cognitive impairment or Alzheimer disease. Journal of Neural Transmission, 121, 433441.Google Scholar
Ng, K. et al. (2017). Neuropsychiatric symptoms predict hypometabolism in preclinical Alzheimer's disease. Neurology, 88, 18141821.Google Scholar
Peters, K. et al. (2006). Characterizing neuropsychiatric symptoms in subjects referred to dementia clinics. Neurology, 66, 523528.CrossRefGoogle ScholarPubMed
Shah, H. et al. (2016). Research priorities to reduce the global burden of dementia by 2025. The Lancet Neurology, 15, 12851294.CrossRefGoogle ScholarPubMed
Sheikh, F. et al. (2017). Prevalence of mild behavioral impairment in mild cognitive impairment and subjective cognitive decline, and its association with caregiver burden. International Psychogeriatrics. doi:10.1017/S104161021700151X Google Scholar
Sherman, C., Liu, C. S., Herrmann, N. and Lanctôt, K. L. (2017). Prevalence, neurobiology, and treatments for apathy in prodromal dementia. International Psychogeriatrics, 18. doi:10.1017/S1041610217000527 Google ScholarPubMed
Singh-Manoux, A. et al. (2017). Trajectories of depressive symptoms before diagnosis of dementia: a 28-year follow-up study. JAMA Psychiatry, 74, 712718. doi:10.1001/jamapsychiatry.2017.0660 CrossRefGoogle ScholarPubMed
Stanciu, I., Larsson, M., Nordin, S., Adolfsson, R., Nilsson, L.-G. and Olofsson, J. K. (2014). Olfactory impairment and subjective olfactory complaints independently predict conversion to dementia: a longitudinal, population-based study. Journal of the International Neuropsychological Society, 20, 209217.Google Scholar
Tapiainen, V., Hartikainen, S., Taipale, H., Tiihonen, J. and Tolppanen, A.-M. (2017). Hospital-treated mental and behavioral disorders and risk of Alzheimer's disease: a nationwide nested case-control study. European Psychiatry, 43, 9298.CrossRefGoogle ScholarPubMed
Ting, C. et al. (2010). Differentiating the cognitive profile of schizophrenia from that of Alzheimer disease and depression in late life. PLoS One, 5, e10151.CrossRefGoogle ScholarPubMed
Winblad, B. et al. (2016). Defeating Alzheimer's disease and other dementias: a priority for European science and society. The Lancet Neurology, 15, 455.Google Scholar