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Disease-specific anxiety symptomatology in Parkinson's disease

Published online by Cambridge University Press:  10 February 2016

Nadeeka N. W. Dissanayaka ,
John D. O'Sullivan ,
Nancy A. Pachana ,
Rodney Marsh ,
Peter A. Silburn ,
Elizabeth X. White ,
Elizabeth Torbey ,
George D. Mellick ,
David A. Copland  and
Gerard J. Byrne
Nadeeka N. W. Dissanayaka*
Affiliation:
UQ Centre for Clinical Research, Royal Brisbane & Women's Hospital, The University of Queensland, Brisbane, Australia Neurology Research Centre, Department of Neurology, Royal Brisbane & Women's Hospital, Brisbane, Australia School of Psychology, The University of Queensland, Brisbane, Australia
John D. O'Sullivan
Affiliation:
Neurology Research Centre, Department of Neurology, Royal Brisbane & Women's Hospital, Brisbane, Australia School of Medicine, Royal Brisbane & Women's Hospital, The University of Queensland, Herston, Brisbane, Australia
Nancy A. Pachana
Affiliation:
School of Psychology, The University of Queensland, Brisbane, Australia
Rodney Marsh
Affiliation:
UQ Centre for Clinical Research, Royal Brisbane & Women's Hospital, The University of Queensland, Brisbane, Australia School of Medicine, Royal Brisbane & Women's Hospital, The University of Queensland, Herston, Brisbane, Australia Mental Health Service, Royal Brisbane & Women's Hospital, Herston, Brisbane, Australia
Peter A. Silburn
Affiliation:
UQ Centre for Clinical Research, Royal Brisbane & Women's Hospital, The University of Queensland, Brisbane, Australia Neurology Research Centre, Department of Neurology, Royal Brisbane & Women's Hospital, Brisbane, Australia School of Medicine, Royal Brisbane & Women's Hospital, The University of Queensland, Herston, Brisbane, Australia
Elizabeth X. White
Affiliation:
UQ Centre for Clinical Research, Royal Brisbane & Women's Hospital, The University of Queensland, Brisbane, Australia School of Medicine, Royal Brisbane & Women's Hospital, The University of Queensland, Herston, Brisbane, Australia
Elizabeth Torbey
Affiliation:
UQ Centre for Clinical Research, Royal Brisbane & Women's Hospital, The University of Queensland, Brisbane, Australia School of Psychology, The University of Queensland, Brisbane, Australia
George D. Mellick
Affiliation:
UQ Centre for Clinical Research, Royal Brisbane & Women's Hospital, The University of Queensland, Brisbane, Australia Neurology Research Centre, Department of Neurology, Royal Brisbane & Women's Hospital, Brisbane, Australia Eskitis Institute for Drug Discovery, Griffith University, Nathan, Brisbane, Australia
David A. Copland
Affiliation:
UQ Centre for Clinical Research, Royal Brisbane & Women's Hospital, The University of Queensland, Brisbane, Australia School of Health & Rehabilitation Sciences, The University of Queensland, St Lucia, Brisbane, Australia
Gerard J. Byrne
Affiliation:
UQ Centre for Clinical Research, Royal Brisbane & Women's Hospital, The University of Queensland, Brisbane, Australia School of Psychology, The University of Queensland, Brisbane, Australia School of Medicine, Royal Brisbane & Women's Hospital, The University of Queensland, Herston, Brisbane, Australia Mental Health Service, Royal Brisbane & Women's Hospital, Herston, Brisbane, Australia
*
Correspondence should be addressed to: Nadeeka Dissanayaka, The University of Queensland, UQ Centre for Clinical Research, Building 71/918 Royal Brisbane & Women's Hospital, Herston QLD4029, Brisbane, Australia. Phone: +61 7 33465577; +61 405715622. E-mail: n.dissanayaka@uq.edu.au.
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Abstract

Background:

Symptoms of anxiety relating to Parkinson's disease (PD) occur commonly and include symptomatology associated with motor disability and complications arising from PD medication. However, there have been relatively few attempts to profile such disease-specific anxiety symptoms in PD. Consequently, anxiety in PD is underdiagnosed and undertreated. The present study characterizes PD-related anxiety symptoms to assist with the more accurate assessment and treatment of anxiety in PD.

Methods:

Ninety non-demented PD patients underwent a semi-structured diagnostic assessment targeting anxiety symptoms using relevant sections of the Mini International Neuropsychiatric Interview (MINI-plus). In addition, they were assessed for the presence of 30 PD-related anxiety symptoms derived from the literature, the clinical experience of an expert panel and the PD Anxiety-Motor Complications Questionnaire (PDAMCQ). The onset of anxiety in relation to the diagnosis of PD was determined.

Results:

Frequent (>25%) PD-specific anxiety symptoms included distress, worry, fear, agitation, embarrassment, and social withdrawal due to motor symptoms and PD medication complications, and were experienced more commonly in patients meeting DSM-IV criteria for an anxiety disorder. The onset of common anxiety disorders was observed equally before and after a diagnosis of PD. Patients in a residual group of Anxiety Not Otherwise Specified had an onset of anxiety after a diagnosis of PD.

Conclusion:

Careful characterization of PD-specific anxiety symptomatology provides a basis for conceptualizing anxiety and assists with the development of a new PD-specific measure to accurately assess anxiety in PD.

Keywords

anxietyParkinson's Diseasesymptomatologyonset
Type
Research Article
Information
International Psychogeriatrics , Volume 28 , Issue 7 , July 2016 , pp. 1153 - 1163
Copyright
Copyright © International Psychogeriatric Association 2016 

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