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Effect of SSRI and calcium channel blockers on depression symptoms and cognitive function in elderly persons treated for hypertension: three city cohort study

Published online by Cambridge University Press:  21 March 2018

Phillip J. Tully ,
Ruth Peters Open the ORCID record for Ruth Peters [Opens in a new window] ,
Karine Pérès ,
Kaarin J. Anstey  and
Christophe Tzourio
Phillip J. Tully*
Affiliation:
Univ. Bordeaux, Inserm, Bordeaux Population Health Research Center, team HEALTHY, UMR1219, F-33000 Bordeaux, France
Ruth Peters
Affiliation:
Centre for Research on Ageing, Health and Wellbeing, Research School of Population Health, The Australian National University, Canberra, Australia
Karine Pérès
Affiliation:
Univ. Bordeaux, Inserm, Bordeaux Population Health Research Center, team SEPIA, UMR1219, F-33000 Bordeaux, France
Kaarin J. Anstey
Affiliation:
Centre for Research on Ageing, Health and Wellbeing, Research School of Population Health, The Australian National University, Canberra, Australia
Christophe Tzourio
Affiliation:
Univ. Bordeaux, Inserm, Bordeaux Population Health Research Center, team HEALTHY, UMR1219, F-33000 Bordeaux, France
*
Correspondence should be addressed to: Phillip Tully, INSERM U1219, Université de Bordeaux, 146 rue Léo Saignat – Case 11, 33076 Bordeaux cedex, France. Phone: +33(0) 547-304-276; Fax: + 33 (0) 5 47 30 42 09. Email: phillip.tully@adelaide.edu.au.
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Abstract

Background:

Emerging genetic, ex-vivo, and clinical trial evidence indicates that calcium channel blockers (CCB) can improve mood and cognitive function. The objective of this study was to examine the effect of selective serotonin reuptake inhibitor (SSRI) therapy augmented with CCB on depression and cognitive decline in an elderly population with hypertension.

Methods:

Prospective study of 296 persons treated with SSRI and antihypertensive drugs. Baseline and two year clinic assessments were used to categorize participants as users of SSRI + CCB (n = 53) or users of SSRI + other antihypertensives (n = 243). Clinic visits were performed up to four times in a ten-year period to assess depression and cognitive function.

Results:

The sample mean age was 75.2 ± 5.47 years and 78% of participants were female. At two year follow-up there was a significant group by time interaction showing lower Center for Epidemiological Studies-Depression (CESD) scores in the SSRI + CCB group, F(1,291) = 4.13, p = 0.043, η2p = 0.014. Over ten-years follow-up, SSRI + CCB use was associated with improved general cognitive function (Mini-Mental State Examination: β = 0.97; 95% CI 0.14 to 1.81, p = 0.023) and immediate visual memory (Boston Visual Retention Test: β = 0.69; 95% CI 0.06 to 1.32, p = 0.033).

Conclusion:

The findings provide general population evidence that SSRI augmentation with CCB may improve depression and cognitive function.

Keywords

hypertensiondepressiongeriatric psychiatryantidepressive agentsselective serotonin reuptake inhibitorscalcium channel blockersmild cognitive impairment
Type
Original Research Article
Information
International Psychogeriatrics , Volume 30 , Issue 9: Issue Theme: Quality of Care for Frail Older Adults , September 2018 , pp. 1345 - 1354
Copyright
Copyright © International Psychogeriatric Association 2018 

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