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Family history of frontotemporal lobar degeneration in Asia – an international multi-center research

Published online by Cambridge University Press:  23 April 2014

Ryuji Fukuhara ,
Amitabha Ghosh ,
Jong-Ling Fuh ,
Jacqueline Dominguez ,
Paulus Anam Ong ,
Aparna Dutt ,
Yi-Chien Liu ,
Hibiki Tanaka  and
Manabu Ikeda
Ryuji Fukuhara
Affiliation:
Department of Neuropsychiatry, Faculty of Life Science, Kumamoto University, 1-1-1, Honjo, Chuo-ku, Kumamoto-city, Japan
Amitabha Ghosh
Affiliation:
Department of Neurology and Cognitive Neurology Unit, Apollo Gleneagles Hospitals, No. 58, Canal Circular Road, Kolkata 700 054, West Bengal, India
Jong-Ling Fuh
Affiliation:
Department of Neurology, Taipei Veterans General Hospital, No. 201, Sec. 2, Shipai Road, Beitou District, Taipei City, Taiwan National Yang-Ming University – School of Medicine, No. 155, Sec. 2, Linong Street, Taipei, Taiwan
Jacqueline Dominguez
Affiliation:
St. Lukes Medical Center, 279 E. Rodrtiguez Sr. Boulevard, Quezon City, Metro Manila, Philippines
Paulus Anam Ong
Affiliation:
Department of Neurology, Hasan Sadikin Hospital, Faculty of Medicine, Padjadjaran University, Bandung, West Java, Indonesia
Aparna Dutt
Affiliation:
Department of Neurology and Cognitive Neurology Unit, Apollo Gleneagles Hospitals, No. 58, Canal Circular Road, Kolkata 700 054, West Bengal, India
Yi-Chien Liu
Affiliation:
Neurological Center, Cardinal Tien Hospital, No. 362, Zhongzheng Road, Xindian District, New Taipei City, 231, Taiwan
Hibiki Tanaka
Affiliation:
Department of Neuropsychiatry, Faculty of Life Science, Kumamoto University, 1-1-1, Honjo, Chuo-ku, Kumamoto-city, Japan
Manabu Ikeda*
Affiliation:
Department of Neuropsychiatry, Faculty of Life Science, Kumamoto University, 1-1-1, Honjo, Chuo-ku, Kumamoto-city, Japan
*
Correspondence should be addressed to: Professor Manabu Ikeda, MD, PhD, Department of Neuropsychiatry, Faculty of Life Sciences, Kumamoto University Hospital, 1-1-1, Honjo, Chuo-ku, Kumamoto-city 860-8556, Japan. Phone: +81-96-373-5566; Fax: +81-96-373-5566. Email: mikeda@kumamoto-u.ac.jp.
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Abstract

Background:

Previous studies in western countries have shown that about 30%–50% of patients with frontotemporal lobar degeneration (FTLD) have a positive family history, whereas the few epidemiological studies on FTLD done in Asia reported much lower frequencies. It is not clear the reason why the frequencies of FTLD with positive family history were lower in Asia. Furthermore, these findings were not from studies focused on family history. Therefore, it is necessary to conduct further studies on the family history of FTLD in Asia. This international multi-center research aims to investigate the family histories in patients with FTLD and related neurodegenerative diseases such as progressive supranuclear palsy (PSP), corticobasal syndrome (CBS), and motor neuron diseases in a larger Asian cohort.

Methods:

Participants were collected from five countries: India, Indonesia, Japan, Taiwan, and Philippines. All patients were diagnosed with behavioral variant frontotemporal dementia (bvFTD), semantic dementia (SD), progressive non-fluent aphasia (PA), frontotemporal dementia with motor neuron disease (FTD/MND), PSP, and corticobasal degeneration (CBD) according to international consensus criteria. Family histories of FTLD and related neurodegenerative diseases were investigated in each patient.

Results:

Ninety-one patients were included in this study. Forty-two patients were diagnosed to have bvFTD, two patients had FTD/MND, 22 had SD, 15 had PA, one had PA/CBS, five had CBS and four patients had PSP. Family history of any FTLD spectrum disorder was reported in 9.5% in bvFTD patients but in none of the SD or PA.

Conclusion:

In contrast to patients of the western countries, few Asian FTLD patients have positive family histories of dementia.

Keywords

Asiaepidemiologyfamily historybvFTDFTLD
Type
Research Article
Information
International Psychogeriatrics , Volume 26 , Special Issue 12: young onset dementia , December 2014 , pp. 1967 - 1971
Copyright
Copyright © International Psychogeriatric Association 2014 

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References

Boeve, B. F., Lang, A. E. and Litvan, I. (2003). Corticobasal degeneration and its relationship to progressive supranuclear palsy and fronto-temporal dementia. Annals of Neurology, 54 (Suppl. 5), S15–S19.CrossRefGoogle Scholar
Brooks, B. R. (1994). El Escorial World Federation of Neurology criteria for the diagnosis of amyotrophic lateral sclerosis. Subcommittee on motor neuron diseases/amyotrophic lateral sclerosis of the World Federation of Neurology Research Group on neuromuscular diseases and the El Escorial “Clinical Limits of Amyotrophic Lateral Sclerosis” workshop contributors. Journal of the Neurological Sciences, 124, 96–107.Google Scholar
Ghosh, A., Dutt, A., Ghosh, M., Bhargava, P. and Rao, S. (2013). Using the revised diagnostic criteria for frontotemporal dementia in India: evidence of an advanced and florid disease. PLoS ONE, 8, e60999.CrossRefGoogle ScholarPubMed
Goldman, J. S. et al. (2005). Comparison of family histories in FTLD subtypes and related tauopathies. Neurology, 65, 1817–1819.Google Scholar
Goldman, J. S., Adamson, J., Karydas, A., Miller, B. L. and Hutton, M. (2007). New genes, new dilemmas: FTLD genetics and its implications for families. American Journal of Alzheimer's Disease and Other Dementias, 22, 507–515.Google Scholar
Gustafson, L. (1987). Frontal lobe degeneration of non-Alzheimer type. II. Clinical picture and differential diagnosis. Archives of Gerontology and Geriatrics, 6, 209–223.Google Scholar
Ikeda, M., Ishikawa, T. and Tanabe, H. (2004). Epidemiology of frontotemporal lobar degeneration. Dementia and Geriatric Cognitive Disorders, 17, 265–268.Google Scholar
Ishizuka, T., Nakamura, M., Ichiba, M. and Sano, A. (2011). Familial semantic dementia with P301L mutation in the Tau gene. Dementia and Geriatric Cognitive Disorders, 31, 334–340.Google Scholar
Litvan, I. et al. (1996). Clinical research criteria for the diagnosis of progressive supranuclear palsy (Steele-Richardson-Olszewski syndrome): report of the NINDS-SPSP international workshop. Neurology, 47, 1–9.Google Scholar
McKhann, G. et al. (1984). Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology, 34, 939–944.Google Scholar
Neary, D. (1999). Overview of frontotemporal dementias and the consensus applied. Dementia and Geriatric Cognitive Disorders, 10 (Suppl. 1), 6–9.Google Scholar
Neary, D. et al. (1998). Frontotemporal lobar degeneration: a consensus on clinical diagnostic criteria. Neurology, 51, 1546–1554.Google Scholar
Rohrer, J. D. et al. (2009). The heritability and genetics of frontotemporal lobar degeneration. Neurology, 73, 1451–1456.Google Scholar
Snowden, J. S., Neary, D. and Mann, D. M. A. (1996). Frontotemporal Lobar Degeneration: Frontotemporal Dementia, Progressive Aphasia, Semantic Dementia. New York, NY: Churchill Livingstone.Google Scholar
Ratnavalli, E., Brayne, C., Dawson, K. and Hodges, J. R. (2002). The prevalence of frontotemporal dementia. Neurology, 58, 1615–1621.Google Scholar
Stevens, M. et al. (1998). Familial aggregation in frontotemporal dementia. Neurology, 50, 1541–1545.Google Scholar
van Swieten, J. C. and Rosso, S. M. (2008). Epidemiological aspects of frontotemporal dementia. Handbook of Clinical Neurology, 89, 331–341.Google Scholar
Wada-Isoe, K. et al. (2012). Epidemiological survey of frontotemporal lobar degeneration in tottori prefecture, Japan. Dementia and Geriatric Cognitive Disorders EXTRA, 2, 381–386.Google Scholar