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Food group intake and brain lesions in late-life vascular depression

Published online by Cambridge University Press:  23 October 2006

Martha E. Payne ,
Pamela S. Haines ,
Lloyd E. Chambless ,
John J. B. Anderson  and
David C. Steffens
Martha E. Payne
Affiliation:
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, U.S.A. Neuropsychiatric Imaging Research Laboratory, Duke University Medical Center, U.S.A. Department of Nutrition, The University of North Carolina at Chapel Hill, U.S.A.
Pamela S. Haines
Affiliation:
Department of Nutrition, The University of North Carolina at Chapel Hill, U.S.A.
Lloyd E. Chambless
Affiliation:
Department of Biostatistics, The University of North Carolina at Chapel Hill, U.S.A.
John J. B. Anderson
Affiliation:
Department of Nutrition, The University of North Carolina at Chapel Hill, U.S.A.
David C. Steffens
Affiliation:
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, U.S.A.
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Abstract

Background: Studies indicate that diet may be related to the occurrence of brain lesions. The cross-sectional association between food intake and brain lesion volumes in late-life depression was examined in a cohort of elderly individuals with current or prior depression.

Methods: Food intake was assessed in 54 elderly vascular depression subjects (vascular depression defined by presence of hyperintensities on brain MRI) using a Block 1998 food frequency questionnaire. Food and kilocalorie intake were determined. Brain lesion volumes were calculated from MRI. Subjects were aged 60 or over and were participants in a longitudinal study of major depression. All subjects received psychiatric assessment and treatment, and medical comorbidity assessments.

Results: High-fat dairy and whole grains were significantly positively correlated with brain lesion volume, while other food groups were not significantly associated with lesion volume. In multivariable analyses, controlling for age, sex, hypertension, diabetes and total kilocalories, the positive association with lesion volume remained significant for both high-fat dairy and whole grains.

Conclusions: High fat dairy and whole grain consumption may be associated with brain lesions in elderly subjects with depression.

Keywords

dietelderlyhyperintensitiesMRIdairy
Type
Research Article
Information
International Psychogeriatrics , Volume 19 , Issue 2 , April 2007 , pp. 295 - 305
Copyright
International Psychogeriatric Association 2007

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