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The impact of depressive symptoms on health-related quality of life in patients with subjective cognitive decline, mild cognitive impairment, and Alzheimer's disease

Published online by Cambridge University Press:  31 August 2016

G. Pusswald ,
D. Moser ,
M. Pflüger ,
A. Gleiss ,
E. Auff ,
E. Stögmann ,
P. Dal-Bianco  and
J. Lehrner
G. Pusswald
Affiliation:
Department of Neurology, Medical University of Vienna, Vienna, Austria
D. Moser
Affiliation:
Department of Neurology, Medical University of Vienna, Vienna, Austria
M. Pflüger
Affiliation:
Department of Neurology, Medical University of Vienna, Vienna, Austria
A. Gleiss
Affiliation:
Center for Medical Statistics, Informatics, and Intelligent Systems, Medical University of Vienna, Vienna, Austria
E. Auff
Affiliation:
Department of Neurology, Medical University of Vienna, Vienna, Austria
E. Stögmann
Affiliation:
Department of Neurology, Medical University of Vienna, Vienna, Austria
P. Dal-Bianco
Affiliation:
Department of Neurology, Medical University of Vienna, Vienna, Austria
J. Lehrner*
Affiliation:
Department of Neurology, Medical University of Vienna, Vienna, Austria
*
Correspondence should be addressed to: Ass. Prof. Priv. Doz. Mag. Dr Johann Lehrner, Department of Neurology, Medical University of Vienna, Währinger Gürtel 18-20, A-1097 Wien. Phone: 0043-1-40400-31090; Fax: 0043-1-40400-31410. Email: Johann.Lehrner@meduniwien.ac.at.
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Abstract

Background:

Health-related quality of life (HRQOL) is an important issue in the context of dementia care. The purpose of this study was to investigate the association between HRQOL and depressive symptoms in patients with subjective cognitive decline (SCD) and subtypes of mild cognitive impairment (MCI) and Alzheimer´s disease (AD).

Methods:

In this cross-sectional, observational study, a control group and four experimental groups (SCD, non-amnestic MCI, amnesticMCI, AD) were compared. Neuropsychological measurers (NTBV) and psychological questionnaires were used for data collection.

Results:

The control group scored higher than patients with SCD, naMCI, aMCI, or AD for the Mental Health Component Score (MHCS) of the Short Form of the Health Survey (SF-36). The Physical Health Component Score (PHCS) of the SF-36 differed only between some groups. Furthermore, cognitive variables were more strongly associated with the physical aspects of HRQOL, whereas depressive symptoms were more strongly related with the mental aspects of HRQOL.

Conclusions:

HRQOL and depressive symptoms are closely related in patients with cognitive impairments. Therefore, it is of great importance to assess patients with subjective impairment carefully in terms of depressive symptoms.

Keywords

subjective cognitive declinehealth-related quality of lifedepressionmild cognitive impairmentAlzheimer‘s disease
Type
Research Article
Information
International Psychogeriatrics , Volume 28 , Issue 12 , December 2016 , pp. 2045 - 2054
Copyright
Copyright © International Psychogeriatric Association 2016 

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