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Improving dementia assessment by reducing sample heterogeneity

Published online by Cambridge University Press:  26 March 2007

Marshal Folstein
Marshal Folstein
Affiliation:
Professor of Psychiatry at Tufts University School of Medicine, Boston, Massachusetts and Johns Hopkins Medical Institutions, Baltimore, Maryland, U.S.A.
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Abstract

Outcome assessment for clinical dementia trials could be enhanced by using the Mini-mental State Examination (MMSE) and the Hopkins Verbal Learning Test (HVLT), in addition to imaging and genetic screening. The statistical power of trials could be increased if heterogeneity of the sample were reduced by the administration of a risk factor inventory which could be used for subject selection or selection of drug responders.

Keywords

outcome assessmentclinical dementia trialsMini-mental State ExaminationHopkins Verbal Learning Test
Type
Consensus papers
Information
International Psychogeriatrics , Volume 19 , Issue 3 , June 2007 , pp. 383 - 389
Copyright
International Psychogeriatric Association 2007

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