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Is bigger better? Towards a mechanistic understanding of neuropsychiatric symptoms in Alzheimer’s disease

Published online by Cambridge University Press:  24 September 2021

Milap A. Nowrangi  and
Paul B. Rosenberg
Milap A. Nowrangi
Affiliation:
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Paul B. Rosenberg*
Affiliation:
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
*
Email: prosenb9@jhmi.edu.
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Abstract

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Type
Commentary
Information
International Psychogeriatrics , Volume 33 , Special Issue 11: Issue Theme: Advances in Assessment and Diagnosis of Dementia , November 2021 , pp. 1129 - 1133
Copyright
© International Psychogeriatric Association 2021

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References

Bruen, P. D., McGeown, W. J., Shanks, M. F. and Venneri, A. (2008). Neuroanatomical correlates of neuropsychiatric symptoms in Alzheimer’s disease. Brain, 131, 2455–2463. doi: 10.1093/brain/awn151.CrossRefGoogle ScholarPubMed
Canevelli, M. et al. (2013). Behavioral and psychological subsyndromes in Alzheimer’s disease using the Neuropsychiatric Inventory. International Journal of Geriatric Psychiatry, 28, 795–803. doi: 10.1002/gps.3904.CrossRefGoogle ScholarPubMed
Catani, M. and ffytche, D. H. (2005). The rises and falls of disconnection syndromes. Brain, 128, 2224–2239. doi: 10.1093/brain/awh622.CrossRefGoogle ScholarPubMed
Elcombe, E. L. et al. (2015). Hippocampal volume in older adults at risk of cognitive decline: the role of sleep, vascular risk, and depression. Journal of Alzheimer’s Disease, 44, 1279–1290. doi: 10.3233/JAD-142016.CrossRefGoogle Scholar
Fischer, C. E., Ting, W. K., Millikin, C. P., Ismail, Z., Schweizer, T. A. and Alzheimer Disease Neuroimaging Initiative (2016). Gray matter atrophy in patients with mild cognitive impairment/Alzheimer’s disease over the course of developing delusions. International Journal of Geriatric Psychiatry, 31, 76–82. doi: 10.1002/gps.4291.CrossRefGoogle ScholarPubMed
Fortea, J. et al. (2011). Cognitively preserved subjects with transitional cerebrospinal fluid ss-amyloid 1-42 values have thicker cortex in Alzheimer’s disease vulnerable areas. Biological Psychiatry, 70, 183–190. doi: 10.1016/j.biopsych.2011.02.017.CrossRefGoogle ScholarPubMed
Geda, Y. E. et al. (2013). Neuropsychiatric symptoms in Alzheimer’s disease: past progress and anticipation of the future. Alzheimer’s & Dementia, 9, 602–608. doi: 10.1016/j.jalz.2012.12.001.CrossRefGoogle Scholar
Hayata, T. T. et al. (2015). Cortical correlates of affective syndrome in dementia due to Alzheimer’s disease. Arquivos de Neuro-Psiquiatria, 73, 553–560. doi: 10.1590/0004-282X20150068.CrossRefGoogle ScholarPubMed
Ismail, Z. et al. (2017). The mild behavioral impairment checklist (MBI-C): a rating scale for neuropsychiatric symptoms in pre-dementia populations. Journal of Alzheimer’s Disease, 56, 929–938. doi: 10.3233/JAD-160979.CrossRefGoogle ScholarPubMed
Lebedev, A. V., Beyer, M. K., Fritze, F., Westman, E., Ballard, C. and Aarsland, D. (2014). Cortical changes associated with depression and antidepressant use in Alzheimer and Lewy body dementia: an MRI surface-based morphometric study. The American Journal of Geriatric Psychiatry, 22, 4–13 e11. doi: 10.1016/j.jagp.2013.02.004.CrossRefGoogle ScholarPubMed
Lee, G. J. et al. (2012). Depressive symptoms in mild cognitive impairment predict greater atrophy in Alzheimer’s disease-related regions. Biological Psychiatry, 71, 814–821. doi: 10.1016/j.biopsych.2011.12.024.CrossRefGoogle ScholarPubMed
Liu, X. et al. (2017). Decreased functional connectivity between the dorsal anterior cingulate cortex and lingual gyrus in Alzheimer’s disease patients with depression. Behavioural Brain Research, 326, 132–138. doi: 10.1016/j.bbr.2017.01.037.CrossRefGoogle ScholarPubMed
Nowrangi, M. A. et al. (2021). The association of neuropsychiatric symptoms with regional brain volumes from patients in a tertiary multi-disciplinary memory clinic. International Psychogeriatrics, 33, 233–244. doi: 10.1017/S1041610220000113.CrossRefGoogle Scholar
Outen, J. D. et al. (2021). Cannabinoids for agitation in Alzheimer’s disease. The American Journal of Geriatric Psychiatry, 4, 1033 DOI 10.1016/j.jagp.2021.01.015.Google Scholar
Porsteinsson, A. P. et al. (2014). Effect of citalopram on agitation in Alzheimer disease: the CitAD randomized clinical trial. JAMA, 311, 682–691. doi: 10.1001/jama.2014.93.CrossRefGoogle ScholarPubMed
Qiu, L. et al. (2014). Regional increases of cortical thickness in untreated, first-episode major depressive disorder. Translational Psychiatry, 4, e378 DOI 10.1038/tp.2014.18.CrossRefGoogle ScholarPubMed
Rafii, M. S. et al. (2014). Neuropsychiatric symptoms and regional neocortical atrophy in mild cognitive impairment and Alzheimer’s disease. American Journal of Alzheimer’s Disease & Other Dementiasr, 29, 159–165. doi: 10.1177/1533317513507373.Google ScholarPubMed
Rosenberg, P. B. et al. (2013). Safety and efficacy of methylphenidate for apathy in Alzheimer’s disease: a randomized, placebo-controlled trial. The Journal of Clinical Psychiatry, 74, 810–816. doi: 10.4088/JCP.12m08099.CrossRefGoogle ScholarPubMed
Rosenberg, P. B., Nowrangi, M. A. and Lyketsos, C. G. (2015). Neuropsychiatric symptoms in Alzheimer’s disease: what might be associated brain circuits? Molecular Aspects of Medicine, 43-44, 25–37. doi: 10.1016/j.mam.2015.05.005.CrossRefGoogle ScholarPubMed
Sala-Llonch, R. et al. (2015). Evolving brain structural changes in PSEN1 mutation carriers. Neurobiology of Aging, 36, 1261–1270. doi: 10.1016/j.neurobiolaging.2014.12.022.CrossRefGoogle ScholarPubMed
Sawczak, C. M., Barnett, A. J. and Cohn, M. (2019). Increased cortical thickness in attentional networks in Parkinson’s disease with minor hallucinations. Parkinson’s Disease, 2019, 5351749 DOI 10.1155/2019/5351749.Google ScholarPubMed
Siafarikas, N., et al. (2021). Neuropsychiatric symptoms and brain morphology in patients with mild cognitive impairment and Alzheimer’s disease with dementia. International Psychogeriatrics, 33, 1217–1228. doi: 10.1017/S1041610221000934.Google Scholar
Storti, L. B., Quintino, D. T., Silva, N. M., Kusumota, L. and Marques, S. (2016). Neuropsychiatric symptoms of the elderly with Alzheimer’s disease and the family caregivers' distress. Revista Latino-Americana de Enfermagem, 24, e2751 DOI 10.1590/1518-8345.0580.2751.CrossRefGoogle ScholarPubMed
Tighe, S. K. et al. (2012). Diffusion tensor imaging of neuropsychiatric symptoms in mild cognitive impairment and Alzheimer’s dementia. The Journal of Neuropsychiatry and Clinical Neurosciences, 24, 484–488. doi: 10.1176/appi.neuropsych.11120375.CrossRefGoogle ScholarPubMed
Trzepacz, P. T. et al. (2013). Frontolimbic atrophy is associated with agitation and aggression in mild cognitive impairment and Alzheimer’s disease. Alzheimer’s & Dementia, 9, 325 DOI 10.1016/j.jalz.2012.10.005.CrossRefGoogle ScholarPubMed
Tschanz, J. T. et al. (2011). Progression of cognitive, functional, and neuropsychiatric symptom domains in a population cohort with Alzheimer dementia: the Cache County Dementia Progression study. The American Journal of Geriatric Psychiatry, 19, 532–542. doi: 10.1097/JGP.0b013e3181faec23.CrossRefGoogle Scholar
Vilalta-Franch, J. et al. (2010). Syndromic association of behavioral and psychological symptoms of dementia in Alzheimer disease and patient classification. The American Journal of Geriatric Psychiatry, 18, 421–432. doi: 10.1097/JGP.0b013e3181c6532f.CrossRefGoogle ScholarPubMed
Wise, E. A., Rosenberg, P. B., Lyketsos, C. G. and Leoutsakos, J. M. (2019). Time course of neuropsychiatric symptoms and cognitive diagnosis in National Alzheimer’s Coordinating Centers volunteers. Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 11, 333–339. doi: 10.1016/j.dadm.2019.02.006.Google ScholarPubMed
Xie, C. et al. (2013). Late-life depression, mild cognitive impairment and hippocampal functional network architecture. Neuroimage: Clinical, 3, 311–320. doi: 10.1016/j.nicl.2013.09.002.CrossRefGoogle ScholarPubMed
Zahodne, L. B., Gongvatana, A., Cohen, R. A., Ott, B. R., Tremont, G. and Alzheimer’s Disease Neuroimaging Initiative (2013). Are apathy and depression independently associated with longitudinal trajectories of cortical atrophy in mild cognitive impairment? The American Journal of Geriatric Psychiatry, 21, 1098–1106. doi: 10.1016/j.jagp.2013.01.043.CrossRefGoogle ScholarPubMed