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Loneliness and cognitive function in the older adult: a systematic review

Published online by Cambridge University Press:  02 January 2015

Lisa Boss ,
Duck-Hee Kang  and
Sandy Branson
Lisa Boss*
Affiliation:
The University of Texas Health Science Center at Houston, 6901 Bertner, Houston TX 77030, Texas, USA
Duck-Hee Kang
Affiliation:
The University of Texas Health Science Center at Houston, 6901 Bertner, Houston TX 77030, Texas, USA
Sandy Branson
Affiliation:
The University of Texas Health Science Center at Houston, 6901 Bertner, Houston TX 77030, Texas, USA
*
Correspondence should be addressed to: Lisa Boss, RN, ACNS-BC, CEN, The University of Texas Health Science Center at Houston, 6901 Bertner, Houston TX 77030, Texas, USA. Phone: 713-500-2146; Fax: 713-500-2142. Email: Lisa.boss@uth.tmc.edu.
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Abstract

Background:

Loneliness is a significant concern among the elderly, particularly in societies with rapid growth in aging populations. Loneliness may influence cognitive function, but the exact nature of the association between loneliness and cognitive function is poorly understood. The purpose of this systematic review was to synthesize current findings on the association between loneliness and cognitive function in older adults.

Method:

A comprehensive, electronic review of the literature was performed. Criteria for inclusion were original quantitative or qualitative research, report written in English, human participants with a mean age ≥ 60 years, and published from January 2000 through July 2013. The total number of studies included in this systematic review was ten.

Results:

Main findings from the ten studies largely indicate that loneliness is significantly and negatively correlated with cognitive function, specifically in domains of global cognitive function or general cognitive ability, intelligence quotient (IQ), processing speed, immediate recall, and delayed recall. However, some initial correlations were not significant after controlling for a wide range of demographic and psychosocial risk factors thought to influence loneliness.

Conclusions:

Greater loneliness is associated with lower cognitive function. Although preliminary evidence is promising, additional studies are necessary to determine the causality and biological mechanisms underlying the relationship between loneliness and cognitive function. Findings should be verified in culturally diverse populations in different ages and settings using biobehavioral approaches.

Keywords

agingelderlylonelinesscognitioncognitive function
Type
Review Article
Information
International Psychogeriatrics , Volume 27 , Issue 4 , April 2015 , pp. 541 - 553
Copyright
Copyright © International Psychogeriatric Association 2015 

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References

Adam, E., Hawkley, L., Kudielka, B. and Cacioppo, J. (2006). Day-to-day dynamics of experience-cortisol associations in a population-based cohort of older adults. Proceedings of the National Academy of sciences USA, 103, 17058–17063.CrossRefGoogle Scholar
Beluche, I., Carriere, I., Ritchie, K. and Ancelin, M. (2010). A prospective study of diurnal cortisol and cognitive function in community-dwelling elderly people. Psychological Medicine, 40, 1039–1049. doi: 10.1017/S00033291709991103.CrossRefGoogle ScholarPubMed
Bennett, D., Schneider, J., Tang, Y., Arnold, S. and Wilson, R. (2006). The effect of social networks on the relation between Alzheimer's disease pathology and level of cognitive function in old people: a longitudinal cohort study. The Lancet Neurology, 5, 406–412.CrossRefGoogle ScholarPubMed
Cacioppo, J. (1994). Social neuroscience: autonomic, neuroendocrine, and immune responses to stress. Psychophysiology, 31, 113–128.CrossRefGoogle ScholarPubMed
Cacioppo, J. and Hawkley, L. (2009). Perceived social isolation and cognition. Trends in Cognitive Sciences, 13, 447–454.CrossRefGoogle ScholarPubMed
Cacioppo, J. et al. (2000). Lonely traits and concomitant physiological processes: the MacArthur social neuroscience studies. International Journal of Psychophysiology, 35, 143–154.Google Scholar
Dallman, M., La Fleur, S., Pecoraro, N.C., Gomez, F., Houshyar, M., and Akana, S. (2004). Mini review: glucocorticoids–food intake, abdominal obesity, and wealthy nations in 2004. Endocrinology, 145, 2633–2638.CrossRefGoogle Scholar
Deary, I., Whiteman, M., Starr, J., Whalley, L. and Fox, H. (2004). The impact of childhood intelligence on later life: following up on the Scottish Mental Surveys of 1932 and 1947. Journal of Personality and Social Psychology, 86, 130–147.Google Scholar
De Jong Gierveld, J. and Tesch-Römer, C. (2012). Loneliness in old age in Eastern and Western European societies. European Journal of Aging, 9, 285–295. doi: 10.1007/s10433-012-0248-2.CrossRefGoogle ScholarPubMed
De Jong Gierveld, J. and van Tilburg, T. (2006). A 6-item scale for overall, emotional, and social loneliness: confirmatory tests on survey data. Research on Aging, 28, 582–598.CrossRefGoogle Scholar
Doane, L. and Adam, E. (2010). Loneliness and cortisol: momentary, day-to-day, and trait associations. Psychoneuroendocrinology, 35, 430–441.CrossRefGoogle ScholarPubMed
Epel, E. (2009). Psychological and metabolic stress: a recipe for accelerated cellular aging? Hormones, 8, 7–22.CrossRefGoogle ScholarPubMed
Fees, B., Martin, P. and Poon, L. (1999). A model of loneliness in older adults. Journal of Gerontology, Psychological Sciences, 54B, 231–239.CrossRefGoogle Scholar
Fiocco, A., Wan, N., Weekes, N., Pim, H. and Lupien, S. (2006). Diurnal cycle of salivary cortisol in older adult men and women with subjective complaints of memory deficits and/or depressive symptoms: relation to cognitive functioning. Stress: The International Journal on the Biology of Stress, 9, 143–152. doi: 10.1080/10253890600965674.Google Scholar
Folstein, M., Folstein, S. and McHugh, P. (1975). Mini-mental state: a practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research, 12, 189–198.CrossRefGoogle Scholar
Fratiglioni, L., Wang, H. X., Ericsson, K., Maytan, M. and Winblad, B. (2000). Influence of social network on occurrence of dementia: a community-based longitudinal study. The Lancet, 355, 1315–1319.Google Scholar
Gilmour, H. (2011). Cognitive performance of Canadian seniors. Health Reports, 22, 27–31.Google Scholar
Glaser, R. and Kiecolt-Glaser, J. (2005). Stress-induced immune dysfunction: implications for health. Nature Reviews Immunology, 5, 243–251.Google Scholar
Gorelick, P. (2010). Role of Inflammation in cognitive impairment: results of observational epidemiological studies and clinical trials. Annals of the New York Academy of Sciences, 1207, 155–162. doi: 10.1111/j.1749-6632.2010.05726.x.CrossRefGoogle Scholar
Gow, A., Corley, J., Starr, J. and Deary, I. (2013). Which social network or support factors are associated with cognitive abilities in old age? Gerontology. Epublished ahead of print, doi: 10.1159/000351265.CrossRefGoogle ScholarPubMed
Gow, A., Pattie, A., Whiteman, M., Whalley, L. and Deary, I. (2007). Social support and successful aging: investigating the relationships between lifetime cognitive change and life satisfaction.Journal of Individual Differences, 28, 103–115. doi: 10.1027/1614-0001.28.3.103.Google Scholar
Hawkley, L. and Cacioppo, J. (2007). Aging and loneliness: downhill quickly? Current Directions in Psychological Science, 16, 187–191.Google Scholar
Heinrich, L. M. and Gullone, E. (2006). The clinical significance of loneliness: a literature review. Clinical Psychology Review, 26, 695–718. doi: 10.1016/j.cpr.2006.04.002.CrossRefGoogle ScholarPubMed
Holmén, K., Ericsson, K. and Winblad, B. (2000). Social and emotional loneliness among non-demented and demented elderly people. Archives of Gerontology and Geriatrics, 31, 177–192.CrossRefGoogle ScholarPubMed
Holwerda, T. et al. (2012). Feelings of loneliness, but not social isolation, predict dementia onset: results from the Amsterdam Study of the Elderly (AMSTEL). Journal of Neurology, Neurosurgery, and Psychiatry. Epublished ahead of print, doi: 10.1136/jnnp-2012-302755.Google ScholarPubMed
Irwin, M. R. (2008). Human psychoneuroimmunology: 20 years of discovery. Brain, Behavior, and Immunity, 22, 129–139.CrossRefGoogle ScholarPubMed
Krause, N. (1991). Stress and isolation from close ties in later life. Journal of Gerontology: Social Sciences, 46, 183–194.CrossRefGoogle ScholarPubMed
Mann, A. (1997). Social support deficits loneliness and life events as risk factors for depression in old age. Psychological Medicine, 27, 323–332.Google Scholar
Nies, M. and McEwen, M. (2011). Community/public Health Nursing Practice: Promoting the Health of Populations, 5th edn. St. Louis: Elsevier.Google Scholar
Noble, J. et al. (2010). Associations of C-reactive protein with cognitive impairment. Archives of Neurology, 67, 87–92.CrossRefGoogle ScholarPubMed
O’Luanaigh, C. et al. (2012). Loneliness and cognition in older people: the Dublin Healthy Ageing Study. Aging and Mental Health, 16, 347–352.CrossRefGoogle ScholarPubMed
Peavy, G. et al. (2009). Effects of chronic stress on memory decline in cognitively normal and mildly impaired older adults. American Journal of Psychiatry, 166, 1384–1391.CrossRefGoogle ScholarPubMed
Peplau, L. A. and Perlman, D. (1982). Perspectives on Loneliness. New York: John Wiley & Sons.Google Scholar
Piazza, J., Almeida, D., Dmitrieva, N. and Klein, L. (2010). Frontiers in the use of biomarkers of health in research on stress and aging. Journal of Gerontology: Psychological Sciences, 65B, 513–525.CrossRefGoogle Scholar
Rotenberg, K. J., Grunman, J. A. and Ariganello, M. (2002). Behavioral confirmation of the loneliness stereotype. Basic Applied Psychology, 24, 81–89.CrossRefGoogle Scholar
Russell, D., Peplau, L. and Cutrona, C. (1980). The revised UCLA loneliness scale: concurrent and discriminant validity evidence. Journal of Personal and Social Psychology, 39, 472–480.CrossRefGoogle ScholarPubMed
Salthouse, T. (2011). Consequences of age-related cognitive declines. Annual Review of Psychology, 63, 5.1–5.6. doi: 10.1146/annurev-psych-120710-100328.Google ScholarPubMed
Schnittger, R., Wherton, J., Prendergast, D. and Lawlor, B. (2012). Risk factors and mediating pathways of loneliness and social support in community-dwelling older adults. Aging and Mental Health, 16, 335–346.CrossRefGoogle ScholarPubMed
Scottish Council for Research in Education (1949). The Trend of Scottish Intelligence. London: University of London Press.Google Scholar
Shankar, A., Hamer, M., McMunn, A. and Steptoe, A. (2013). Social isolation and loneliness: relationships with cognitive function during 4 years of follow-up in the English longitudinal study of ageing. Psychosomatic Medicine, 75, 161–170. doi: 10.1097/PSY.0b013e31827f09cd.CrossRefGoogle ScholarPubMed
Silva, M. (2008). Development of the WAIS-III: A brief overview, history, and description.Graduate Journal of Counseling Psychology, 1, 117–135.Google Scholar
Sonnen, J. et al. (2009). Free radical damage to cerebral cortex in Alzheimer's disease, microvascular brain injury, and smoking. Annals of Neurology, 65, 226–229.CrossRefGoogle ScholarPubMed
Steptoe, A., Owen, N., Kunz-Ebrecht, S. and Brydon, L. (2004). Loneliness and neuroendocrine, cardiovascular, and inflammatory stress responses in middle-aged men and women. Psychoneuroendocrinology, 29, 593–611. doi: 10.1016/S0306-4530(03)00086-6.CrossRefGoogle ScholarPubMed
Steptoe, A., Shankar, A., Demakakos, P. and Wardell, J. (2013). Social isolation, loneliness, and all-cause mortality in older men and women. Proceedings of the National Academy of Sciences, 110, 5797–5801.Google Scholar
Stoykova, R., Matharan, F., Dartigues, J. and Amieva, H. (2011). Impact of social network on cognitive performances and age-related cognitive decline across a 20-year follow-up. International Pscyhogeriatrics, 23, 1405–1412.Google Scholar
Strack, A., Sebastian, R., Schwartz, M., Dallman, M. (1995). Glucocorticoids and insulin: reciprocal signals for energy balance. American Journal of Physiology, 268, 142–149.Google ScholarPubMed
Struble, L. M. and Sullivan, B. J. (2011). Cognitive health in older adults. The Nurse Practitioner, 36, 24–34.CrossRefGoogle ScholarPubMed
Theeke, L. (2009). Predictors of loneliness in US adults over age sixty-five. Archives of Psychiatric Nursing, 23, 387–396. doi: 10.1016/j.apnu.2008.11.002.CrossRefGoogle ScholarPubMed
Tilvis, R., Kähönen-Väre, M., Jolkkonen, J., Valvanne, J., Pitkala, K., and Strandberg, T. (2004). Predictors of cognitive decline and mortality of aged people over a 10-year period. Journal of Gerontology: Medical Sciences, 59A, 268–274.Google Scholar
Turner, R. (1989). Individual differences in heart rate response during behavioral challenge. Psychophysiology, 26, 497–505.Google Scholar
Victor, C., Grenade, L. and Boldy, D. (2005). Measuring loneliness in later life: a comparison of differing measures. Reviews in Clinical Gerontology, 15, 63–70.Google Scholar
Wechsler, D. (1997). Wechsler Adult Intelligence Scale, 3rd edn. San Antonio, TX: Psychological Corporation.Google Scholar
Weiss, R. S. (1973). Loneliness: The Experience of Emotional and Social Isolation. London: MIT Press.Google Scholar
Wilson, R et al. (2007). Loneliness and risk of Alzheimer disease. Archives of General Psychiatry, 64, 234–240.Google Scholar
Ye, L., Hawkley, L., Waite, L. and Cacioppo, J. (2012). Loneliness, health, and mortality in old age: a national longitudinal study. Social Science and Medicine, 74, 907–914.Google Scholar