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A survey of attitudes of clinicians towards the diagnosis and treatment of mild cognitive impairment in Australia and New Zealand

Published online by Cambridge University Press:  01 February 2008

Terry Mitchell*
Affiliation:
Older People's Health, Auckland City Hospital, New Zealand
Michael Woodward
Affiliation:
Aged and Residential Care, Heidelberg Repatriation Hospital, Victoria, Australia
Yuichi Hirose
Affiliation:
School of Mathematics, Statistics and Computer Science, Victoria University of Wellington, New Zealand
*
Correspondence should be addressed to: Dr. Terry Mitchell, Older People's Health, 6th Floor, Support Building, Auckland City Hospital, PB 92024, Auckland, New Zealand. Phone: +64 2162 0549; Fax: +64 9387 2897. Email: terrym@adhb.govt.nz.
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Abstract

Objectives: The aim of the study was to assess the attitudes of clinicians to the diagnostic construct of mild cognitive impairment (MCI), their approach to relaying the diagnosis to patients and families, and recommended treatment and follow-up.

Method: An anonymous questionnaire was sent out to 503 members of the Australian Society for Geriatric Medicine (ASGM) and New Zealand Geriatrics Society (NZGS), of whom 163 replied.

Results: Most responders (83%) had diagnosed MCI. About 70% rated the importance of separating MCI from dementia, or MCI from normal cognition, as 4 or 5 on a scale from 1 (not very important) to 5 (very important). Most responders reported that they would inform their patients and families of a diagnosis of MCI, and used that term. A minority used the term “early Alzheimer's disease,” but 44% of NZGS members used other terms to relay the diagnosis compared to 13% of ASGM members. Follow-up was most often recommended at 6–12 months. Non-pharmacological treatment (such as mental stimulation strategies) was recommended most often, followed by no treatment.

Conclusions: The diagnostic entity of MCI appears to have a general acceptance among those who responded to the survey, and the term has gained use in clinical practice. Most clinicians are recommending follow-up, recognizing the high risk for progression. Treatment recommendations do not favor pharmaceuticals, reflecting the current evidence for lack of effect.

Type
Research Article
Copyright
Copyright © International Psychogeriatric Association 2007

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References

Anderson, M. J. 2001. A new method for non-parametric multivariate analysis of variance. Austral Ecology, 26, 3246.Google Scholar
Bamford, C., Lamont, S., Eccles, M., Robinson, L., May, C. and Bond, J. 2004. Disclosing a diagnosis of dementia: a systematic review. International Journal of Geriatric Psychiatry, 19, 151169.Google Scholar
Bennett, D. A., Schneider, J. A., Bienias, J. L., Evans, D. A. and Wilson, R. S. 2005. Mild cognitive impairment is related to Alzheimer disease pathology and cerebral infarctions. Neurology, 64, 834841.CrossRefGoogle ScholarPubMed
Bennett, D. A. et al. . 2006. Neuropathology of older persons without cognitive impairment from two community-based studies. Neurology, 66, 18371844.Google Scholar
Chételat, G. et al. . 2005. FDG–PET measurement is more accurate than neuropsychological assessments to predict global cognitive deterioration in patients with mild cognitive impairment. Neurocase, 11, 1425.CrossRefGoogle ScholarPubMed
Galvin, J. E. et al. . 2005. Predictors of preclinical Alzheimer disease and dementia: a clinicopathologic study. Archives of Neurology, 62, 758765.CrossRefGoogle ScholarPubMed
Ganguli, M., Dodge, H. H., Shen, C. and DeKosky, S. T. 2004. Mild cognitive impairment, amnestic type: an epidemiologic study. Neurology, 63, 115121.Google Scholar
Gauthier, S. et al. . 2006. Mild cognitive impairment. Lancet, 367, 12621270.CrossRefGoogle ScholarPubMed
Gillespie, N. D. and McMurdo, M. E. T. 1999. A survey of attitudes and knowledge of geriatricians to driving in elderly patients. Age and Ageing, 28, 5357.CrossRefGoogle ScholarPubMed
Hansson, O., Zetterberg, H., Buchhave, P., Londos, E., Blennow, K. and Minthon, L. 2006. Association between CSF biomarkers and incipient Alzheimer's disease in patients with mild cognitive impairment: a follow-up study. Lancet Neurology, 5, 228234.CrossRefGoogle ScholarPubMed
Hofman, A. et al. . 1997. Atherosclerosis, apolipoprotein E, and prevalence of dementia and Alzheimer's disease in the Rotterdam Study. Lancet, 349, 151154.CrossRefGoogle ScholarPubMed
Howieson, D. B., Holm, L. A., Kaye, J. A., Oken, B. S. and Howieson, J. 1993. Neurologic function in the optimally healthy oldest old: neuropsychological evaluation. Neurology, 43, 18821886.CrossRefGoogle ScholarPubMed
Jicha, G. A. et al. . 2006. Neuropathologic outcome of mild cognitive impairment following progression to clinical dementia. Archives of Neurology, 63, 674681.CrossRefGoogle ScholarPubMed
Korf, E. S. C., Wahlund, L. O., Visser, P. J. and Scheltens, P. 2004. Medial temporal lobe atrophy on MRI predicts dementia in patients with mild cognitive impairment. Neurology, 63, 94100.CrossRefGoogle ScholarPubMed
Larrieu, S. et al. . 2002. Incidence and outcome of mild cognitive impairment in a population-based prospective cohort. Neurology, 59, 15941599.CrossRefGoogle Scholar
McArdle, B. H. and Anderson, M. J. 2001. Fitting multivariate models to community data: a comment on distance-based redundancy analysis. Ecology, 82, 290297.CrossRefGoogle Scholar
McGuinness, B., Todd, S., Passmore, P. and Bullock, R. 2006. Blood pressure lowering in patients without prior cerebrovascular disease for prevention of cognitive impairment and dementia. The Cochrane Database of Systematic Reviews, Issue 2. Art. no.: CD004034. DOI: 10.1002/14651858.CD004034.pub2.CrossRefGoogle Scholar
Mayor, S. 2005. Regulatory authorities review use of galantamine in mild cognitive impairment. BMJ, 330, 276.Google ScholarPubMed
Morris, J. C. and Cummings, J. 2005. Mild cognitive impairment (MCI) represents early-stage Alzheimer's disease. Journal of Alzheimer's Disease, 7, 235239.CrossRefGoogle ScholarPubMed
Petersen, R. C. 2004. Mild cognitive impairment as a diagnostic entity. Journal of Internal Medicine, 256, 183194.CrossRefGoogle ScholarPubMed
Petersen, R. C. and Bennett, D. 2005. Mild cognitive impairment: is it Alzheimer's disease or not? Journal of Alzheimer's Disease, 7, 241245.CrossRefGoogle ScholarPubMed
Petersen, R. C. and Knopman, D. S. 2006. MCI is a clinically useful concept. International Psychogeriatrics, 18, 394402.Google ScholarPubMed
Petersen, R. C., Stevens, J. C., Ganguli, M., Tangalos, E. G., Cummings, J. L. and DeKosky, S. T. 2001. Practice parameter: early detection of dementia: mild cognitive impairment (an evidence-based review). Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology, 56, 11331142.CrossRefGoogle Scholar
Petersen, R. C. et al. . 2005. Vitamin E and donepezil for the treatment of mild cognitive impairment. New England Journal of Medicine, 352, 23792388.CrossRefGoogle ScholarPubMed
Petersen, R. C. et al. . 2006. Neuropathologic features of amnestic mild cognitive impairment. Archives of Neurology, 63, 665672.Google Scholar
PROGRESS Collaborative Group. 2003. Effects of blood pressure lowering with perindopril and indapamide therapy on dementia and cognitive decline in patients with cerebrovascular disease. Archives of Internal Medicine, 163, 10691075.CrossRefGoogle Scholar
Ritchie, K., Artero, S. and Touchon, J. 2001. Classification criteria for mild cognitive impairment: a population-based validation study. Neurology, 56, 3742.CrossRefGoogle ScholarPubMed
Schiff, R., Sacares, P., Snook, J., Rajkumar, C. and Bulpitt, C. J. 2006. Living wills and the Mental Capacity Act: a postal questionnaire survey of UK geriatricians. Age and Ageing, 35, 116121.Google Scholar
Small, S. A. 2001. Age-related memory decline: current concepts and future directions. Archives of Neurology, 58, 360364.CrossRefGoogle ScholarPubMed
Small, S. A., Stern, Y., Tang, M. and Mayeux, R. 1999. Selective decline in memory function among healthy elderly. Neurology, 52, 13921396.CrossRefGoogle ScholarPubMed
Thal, L. J. et al. . 2005. A randomized, double-blind, study of rofecoxib in patients with mild cognitive impairment. Neuropsychopharmacology, 30, 12041215.Google Scholar
Tian, J., Bucks, R. S., Haworth, J. and Wilcock, G. 2003. Neuropsychological prediction of conversion to dementia from questionable dementia: statistically significant but not yet clinically useful. Journal of Neurology, Neurosurgery, and Psychiatry, 74, 433438.CrossRefGoogle Scholar
Visser, P. J. and Brodaty, H. 2006. MCI is not a clinically useful concept. International Psychogeriatrics, 18, 402409.Google Scholar
Whitehouse, P. J., Gaines, A. D., Lindstrom, H. and Graham, J. E. 2005. Anthropological contributions to the understanding of age-related cognitive impairment. Lancet Neurology, 4, 320326.CrossRefGoogle Scholar
Zelinski, E. M. and Burnight, K. P. 1997. Sixteen-year longitudinal and time lag changes in memory and cognition in older adults. Psychology and Aging, 12, 503513.CrossRefGoogle ScholarPubMed